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Kevin Rodzinak
Vadim Y Dudkin, Mark E Fraley, Kenneth L Arrington, Mark E Layton, Alexander J Reif, Kevin J Rodzinak, Joseph E Pero: Positive allosteric modulators of MGLUR2. Merck Sharp & Dohme, Keith D MacMillan, John C Todaro, March 31, 2015: US08993779 (1 worldwide citation)

The present invention is directed to benzimidazolone derivatives which are positive allosteric modulators of the mGluR2 receptor, useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 receptor is involve ...


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Stéphane De Lombaert
CHEN Zhidong, DE LOMBAERT Stéphane, DINES Jonathon Alan, LIU Weimin, LO Ho Yin, LOKE Pui Leng: INHIBITEURS BENZIMIDAZOLES DE LA PRODUCTION DE LEUCOTRIÈNES, BENZIMIDAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION. BOEHRINGER INGELHEIM INTERNATIONAL, CHEN Zhidong, DE LOMBAERT Stéphane, DINES Jonathon Alan, LIU Weimin, LO Ho Yin, LOKE Pui Leng, MORRIS Michael P, May 3, 2012: WO/2012/058254

The present invention relates to compounds of formula IA and IB and pharmaceutically acceptable salts thereof, wherein R1-R7 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various disea ...


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Lee Funk
Jingrong Jean Cui, Lee Andrew Funk, Lei Jia, Pei Pei Kung, Jerry Jialun Meng, Mitchell David Nambu, Mason Alan Pairish, Hong Shen, Michelle Tran Dube: Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors. Agouron Pharmaceuticals, October 18, 2012: US20120263706-A1

Enantiomerically pure compound of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.


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Lee Funk
Jingrong Jean Cui, Lee Andrew Funk, Lei Jia, Pei Pei Kung, Jerry Jialun Meng, Mitchell David Nambu, Mason Alan Pairish, Hong Shen, Michelle Tran Dube: Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors. Agouron Pharmaceuticals, Pfizer, December 23, 2010: US20100324061-A1

Enantiomerically pure compound of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.


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Lee Funk
Jingrong Jean Cui, Lee Andrew Funk, Lei Jia, Pei Pei Kung, Jerry Jialun Meng, Mitchell David Nambu, Mason Alan Pairish, Hong Shen, Michelle Tran Dube: Aminoheteroaryl compounds as protein kinase inhibitors. Agouron Pharmaceuticals, Agouron Pharmaceuticals, August 10, 2006: US20060178374-A1

Aminoheteroaryl compounds are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.


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Barker Andrew John: Quinazoline derivatives.. Zeneca, October 20, 1993: EP0566226-A1 (278 worldwide citation)

The invention concerns quinazoline derivatives of the formula I wherein m is 1, 2 or 3 and each R includes hydroxy, amino, carboxy, carbamoyl, ureido, (1-4C)alkoxycarbonyl, N-(1-4C)alkylcarbamoyl, N,N-di-[(1-4C)alkyl]carbamoyl, hydroxyamino, (1-4C)alkoxyamino, (2-4C)alkanoyloxyamino, trifluoromethox ...


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Carini David John, Wong Pancras Chor Bun, Duncia John Jonas Vytautas: Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids.. Du Pont, July 19, 1989: EP0324377-A2 (169 worldwide citation)

The invention encompasses a pharmaceutical composition comprising a diuretic or a non-steroidal antiinflammatory drug, a pharmaceutical suitable carrier and an antihypertensive and processes for production of these compositions.


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Barker Andrew John, Brown Dearg Sutherland: Quinazoline derivatives.. Zeneca, June 22, 1994: EP0602851-A1 (147 worldwide citation)

The invention concerns quinazoline derivatives of the formula I wherein m is 1, 2 or 3 and each R includes hydroxy, amino, ureido, hydroxyamino, trifluoromethoxy, (1-4C)alkyl, (1-4C)alkoxy and (1-3C)alkylenedioxy; and and Q is a 9- or 10-membered bicyclic heterocyclic moiety containing one or two ni ...