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Stéphane De Lombaert
Bakthavatchalam Rajagopal, Darrow James W, de, Lombaert Stéphane, Zheng Xiaozhang: Substituted pyridin-2-ylamine analogues. Neurogen Corporation, Bakthavatchalam Rajagopal, Darrow James W, de, Lombaert Stéphane, Zheng Xiaozhang, ALEXANDER John B, February 3, 2005: WO/2005/009980 (56 worldwide citation)

Substituted pyridin-2-ylamine analogues are provided, of the formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with patholog ...


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Stéphane De Lombaert
Bakthavatchalam Rajagopal, Blum Charles A, Brielmann Harry, Chenard Bertrand L, de, Lombaert Stéphane, Hodgetts Kevin J, Hutchison Alan, Yoon Taeyoung, Zheng Xiaozhang: Biaryl piperazinyl-pyridine analogues. Neurogen Corporation, Bakthavatchalam Rajagopal, Blum Charles A, Brielmann Harry, Chenard Bertrand L, de, Lombaert Stéphane, Hodgetts Kevin J, Hutchison Alan, Yoon Taeyoung, Zheng Xiaozhang, ALEXANDER John B, January 27, 2005: WO/2005/007648 (17 worldwide citation)

Biaryl piperazinyl -pyri dine analogues are provided, of the Formula (I): wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with path ...


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Stéphane De Lombaert
Raymond F Horvath, Jennifer N Tran, Stéphane De Lombaert, Kevin J Hodgetts, Philip A Carpino, David A Griffith: Certain alkylene diamine-substituted heterocycles. Neurogen Corporation, Pfizer, Ladas & Parry, February 24, 2004: US06696445 (3 worldwide citation)

The present invention also provides a general method to whereby mono-, bi-, or tricyclic heterocycles may be modified to obtain potent antagonists at the NPY


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Kevin Rodzinak
Vadim Y Dudkin, Mark E Fraley, Kenneth L Arrington, Mark E Layton, Alexander J Reif, Kevin J Rodzinak, Joseph E Pero: Positive allosteric modulators of MGLUR2. Merck Sharp & Dohme, Keith D MacMillan, John C Todaro, March 31, 2015: US08993779 (1 worldwide citation)

The present invention is directed to benzimidazolone derivatives which are positive allosteric modulators of the mGluR2 receptor, useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 receptor is involve ...


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Stéphane De Lombaert
Bakthavatchalam Rajagopal, Blum Charles A, Brielmann Harry L, Caldwell Timothy M, de, Lombaert Stéphane, Hodgetts Kevin J, Yoon Taeyoung, Zheng Xiaozhang: Substituted quinazolin-4-ylamine analogues as modulators of capsaicin. Neurogen Corporation, Bakthavatchalam Rajagopal, Blum Charles A, Brielmann Harry L, Caldwell Timothy M, de, Lombaert Stéphane, Hodgetts Kevin J, Yoon Taeyoung, Zheng Xiaozhang, CRAWFORD Bradley W, July 31, 2003: WO/2003/062209

This invention relates generally to substituted quinazolin-4-ylamine analogues that are modulators of capsaicin receptors, and to the use of such compounds for treating conditions related to capsaicin receptor activation. The invention further relates to the use such compounds as probes for the dete ...


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Prabhu Mohapatra
Laxminarayan Bhat, Prabhu P Mohapatra, Seema Rani Bhat: Compositions, synthesis, and methods of using quinolinone based atypical antipsychotic agents. Reviva Pharmaceuticals, Perkins Coie, Viola T Kung, August 21, 2012: US08247420

The present invention provides novel quinolinone derivatives which can be advantageously used for treating schizophrenia and related psychoses such as acute manic, bipolar disorder, autistic disorder, and depression.


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Ulf K Junggren, Sven E Sjostrand: Gastric acid secretion inhibiting substituted 2-(2-benzimidazolyl)-pyridines, pharmaceutical preparations containing same, and method for inhibiting gastric acid secretion. Aktiebolaget Hassle, Brumbaugh Graves Donohue & Raymond, March 10, 1981: US04255431 (173 worldwide citation)

The present invention relates to novel compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and are each hydrogen, alkyl, halogen, carbomethoxy, carbethoxy, alkoxy, or alkanoyl, R.sup.6 is hydrogen, methyl or ethyl, R.sup.3, R.sup.4 and R.sup.5 are the same or diff ...