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Kevin Rodzinak
Vadim Y Dudkin, Mark E Fraley, Kenneth L Arrington, Mark E Layton, Alexander J Reif, Kevin J Rodzinak, Joseph E Pero: Positive allosteric modulators of MGLUR2. Merck Sharp & Dohme, Keith D MacMillan, John C Todaro, March 31, 2015: US08993779 (1 worldwide citation)

The present invention is directed to benzimidazolone derivatives which are positive allosteric modulators of the mGluR2 receptor, useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 receptor is involve ...


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Carini David John, Wong Pancras Chor Bun, Duncia John Jonas Vytautas: Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids.. Du Pont, July 19, 1989: EP0324377-A2 (169 worldwide citation)

The invention encompasses a pharmaceutical composition comprising a diuretic or a non-steroidal antiinflammatory drug, a pharmaceutical suitable carrier and an antihypertensive and processes for production of these compositions.


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Sugimoto Hachiro, Tsuchiya Yutaka, Higurashi Kunizou, Karibe Norio, Iimura Yuoichi, Sasaki Atsushi, Yamanashi Yoshiharu, Ogura Hiroo, Araki Shin Kashiwa Mansion, Kosasa Takashi, Kusota Atsuhiki, Kozasa Michiko, Yamatsu Kiyomi: Cyclic amine compound, its use and pharmaceutical compositions comprising it.. Eisai, December 28, 1988: EP0296560-A2 (141 worldwide citation)

A cyclic amine compound is defined by the formula: in which J is indanyl, indanonyl, indenyl, indenonyl, indanedionyl, tetralonyl, benzosuberonyl, indanolyl or a divalent group thereof, K is phenyl, an arylalkyl or cynnamyl, B is -(CHR22)r-, R22 being H or methyl, -CO-(CHR22)r-, =(CH-CH=CH)b-, =CH-( ...


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Emonds Alt Xavier, Goulaouic Pierre, Proietto Vincenzo, Van Broeck Didier: Compounds of aromatic amines and their enantiomers, process for their preparation and pharmaceutical compositions containing them.. Sanofi, May 22, 1991: EP0428434-A2 (138 worldwide citation)

The invention relates to compounds of formula in which: - m is an integer from 1 to 3; - Ar and Ar' represent, independently, a thienyl group, a substituted or unsubstituted phenyl group; an imidazolyl group; it also being possible for Ar' to be a benzothienyl group, unsubstituted or substituted wit ...


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Chandraratna Roshantha A S: Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity.. Allergan, September 28, 1988: EP0284288-A1 (135 worldwide citation)

Retinoid-like activity is exhibited by compounds of the formula where X is S, O, or NR' where R' is hydrogen or lower alkyl; R is hydrogen or lower alkyl; A is pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl or pyrazinyl; n is 0-5; and B is H, -COOH or a pharmaceutically acceptable salt, ester or ...


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Edwin Bernard Villhauer: N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV. Novartis, Joseph J Borovian, January 4, 2000: US06011155 (125 worldwide citation)

N-(N'-substituted glycyl)-2-cyanopyrrolidines of formula I ##STR1## Compounds of formula I inhibit DPP-IV (dipeptidyl-peptidase-IV) activity. They are therefore indicated for use as pharmaceuticals in inhibiting DPP-IV and in the treatment of conditions mediated by DPP-IV, such as non-insulin-depend ...


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Takeuchi Makoto, Naito Ryo, Morihira Koichiro, Hayakawa Masahiko, Ikeda Ken, Isomura Yasuo: Novel carbamate derivative and medicinal composition containing the same. Yamanouchi Pharma, December 11, 1996: EP0747355-A1 (125 worldwide citation)

Carbamate derivatives represented by the general formula (I), salts thereof, hydrates thereof or solvates thereof wherein each symbol has the following meaning: A ring: a benzene ring or a pyridine ring, B ring: a nitrogen-containing saturated hetero-ring which may have a substituent on the nitrogen ...


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Sugavanam Balasubramanyan: Triazole compounds, a process for preparing them, their use as plant fungicides and fungicidal compositions containing them.. Ici, May 26, 1982: EP0052424-A2 (117 worldwide citation)

Compounds of the formula: wherein R is -CH=CH-X, -C IDENTICAL C-X or -CH2-CH2-X where X is H, alkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl or optionally substituted aryl, aralkyl, aryloxyalkyl, or heterocycle; R is alkyl, cycloalkyl or optionally substituted aryl; Z is Cl, CN or OR where R is H, ace ...


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Vandenberk Jan, Kennis Ludo Edmond Josephine, Van Der Aa Marcel Josef Maria, Van Heertum Albert Henricus Ma: (Piperidinylalkyl)Quinazoline derivatives, process for their preparation and pharmaceutical compositions containing them.. Janssen Pharmaceutica, July 23, 1980: EP0013612-A2 (108 worldwide citation)

Quinazoline derivatives of the formula wherein Ra is hydrogen or alkyl and and q is 2 or 3; R is hydorgen, hydroxy and alkyl; Alk is an alkylene chain having from 1 to 4 carbon atoms and Q is a quinazolinyl radical, the 1-, 2-, 3- or 4-position of which is connected with the alkylene side chain, sai ...