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Petpiboon Prasit, Daniel Guay, Zhaoyin Wang, Serge Leger, Michel Therien: Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2. Merck Frosst Canada, Curtis C Panzer, David L Rose, May 28, 1996: US05521213 (155 worldwide citation)

The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encomp ...


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Musser John H, Chakraborty Utpal Ranjan: Anti-inflammatory/anti-allergic compounds.. Usv Pharma, May 21, 1986: EP0181568-A2 (145 worldwide citation)

Compounds of the formula: Ar1 - X - Ar - Z - (R)n min and salts thereof, wherein Ar1 is a nitrogen, sulfur, oxygen heterocyclic ring or aromatic ring; Ar is a phenyl ring or a nitrogen, oxygen or sulfur heterocyclic ring; Ar and Ar1 may be fully substituted or less than fully substituted with H, CH3 ...


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Branca Quirico Dr, Maerki Hans Peter Dr, Neidhart Werner Dr, Ramuz Henri Prof Dr, Wostl Wolfgang Dr: Peptide derivatives of amino acids having a renin-inhibiting effect.. Hoffmann La Roche, October 3, 1990: EP0389898-A2 (139 worldwide citation)

The compounds of the formula in which A, R, R, R and R have the meaning stated in Claim 1, in the form of optically pure diastereomers, mixtures of diastereomers, diastereomeric racemates or mixtures of diastereomeric racemates, and pharmaceutically utilisable salts thereof, inhibit the action of th ...


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Klaus Michael Dr, Weiss Ekkehard Dr: Tetrahydronaphthalène and indane derivatives, their synthesis and application in pharmaceutical preparations.. Hoffmann La Roche, January 20, 1988: EP0253302-A2 (110 worldwide citation)

Die Verbindungen der allgemeinen Formel worin X und Y -CH2- oder >C(CH3)2; Z einen Rest -CHR-, >CO, >CROR, -CHR-CHR-, -CHOR-CH2-, -CO-CHOR- oder -CHOR-CHOR- darstellt; R einen 5- oder 6-gliedrigen, mono-cyclisch-heterocyclischen Rest darstellt, der durch Halogen, nieder-Alkyl, nieder-Alkoxy, Acyloxy ...


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Klaus Michael Dr, Weiser Harald Dr, Loeliger Peter Dr: Heterocyclic compounds and rodenticides containing them.. Hoffmann La Roche, January 18, 1984: EP0098591-A1 (110 worldwide citation)

Verbindungen der allgemeinen Formel worin X -CH = CH-, -O- oder -S- ist; R ein Rest Ar-R oder -CH = CH-C(CH3) = CH-R; Ar Phenyl, Pyridyl, Furyl oder Thienyl; R ein Rest -CO2R , -C(O)R, -CH2OR , nieder-Alkylsulfonyl oder Formyl; R ein Rest -CO2R , -C(O)R, -CH2OR oder Formyl; R Wasserstoff oder nieder ...


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Inamura Kazue, Kanaya Naoaki, Nagahara Takayasu, Yokoyama Yukio: Aromatic amidine derivatives and salts thereof.. Daiichi Seiyaku Co, May 5, 1993: EP0540051-A1 (99 worldwide citation)

An anticoagulant agent which comprises, as an active ingredient, an aromatic amidine derivative represented by the following general formula (1) or a salt thereof: wherein the group represented by is a group selected from indolyl, benzofuranyl, benzothienyl, benzimidazolyl, benzoxazolyl, benzothiazo ...


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Banholzer Rolf Dr, Bauer Rudolf Dr, Reichl Richard Dr: Thienylcarboxylic acid ester of aminoalcohols, their quaternary products, their preparation and use of the compounds.. Boehringer Ingelheim Kg, Boehringer Ingelheim Int, March 27, 1991: EP0418716-A1 (95 worldwide citation)

The new compounds of formula (I) (where A, R1, Ra and R2 are defined in the description) can be manufactured by processes known per se and used as the active ingredients of drugs.


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Jones Charles David: Benzothiophene compounds and process for preparing them.. Lilly Co Eli, October 13, 1982: EP0062503-A1 (93 worldwide citation)

6-Hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-[3-methylpyrrolidino]ethoxy)benz oyl]be n zo[b]thiophene, its ethers and esters, and the physiologically acceptable acid addition salts thereof, and 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo[b ]-thiophen e, its ethers and esters, and t ...


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Gubin Jean, Lucchetti Jean, Inion Henri, Chatelain Pierre, Rosseels Gilbert, Kilenyi Steven: Benzofuran derivatives, benzothiophenes, indoles or indolizines, process for production and compositions containing them.. Sanofi, Sanofi Pharma, February 19, 1992: EP0471609-A1 (85 worldwide citation)

L'invention a pour objet des dérivés de benzofuranne, benzothiophène, indole ou indolizine de formule générale : dans laquelle : Het représente l'un des groupements dans lesquels : T, T' et T" représentent notemment un groupement : X représente -O- ou -S- Y représente un radical Ces dérivés sont uti ...