1
Brooks Dee W, Summers James B: Indole-, benzofuran-, and benzothiophene-containing lipoxygenase-inhibiting compounds.. Abbott Lab, March 13, 1991: EP0416609-A2 (69 worldwide citation)

Pro-drugs of potent 5-lipoxygenase inhibiting compounds comprise compounds of the formula in which A is an alkylene or alkenylene group, X is oxygen, sulfur, sulfoxyl, or substituted nitrogen, and Y is a group which includes substituted or unsubstituted carbocyclic or substituted or unsubstituted he ...


2
Audia James E, Hibschman David J, Krushinski Jr Joseph H, Mabry Thomas E, Nissen Jeffrey S, Rasmussen Kurt, Rocco Vincent P, Schaus John M, Thompson Dennis C, Wong David T: Compounds having effects on serotonin-related systems. Lilly Co Eli, July 24, 1996: EP0722941-A2 (57 worldwide citation)

A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1A receptor. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the tr ...


3
Miller Chris P, Tran Bach D, Collini Michael D: Estrogenic agents. American Home Prod, October 22, 1997: EP0802183-A1 (47 worldwide citation)

The present invention relates to new 2-Phenyl-1-Ä4-(2-Aminoethoxy)-BenzylÜ-Indole compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds, which have the general structures below:


4
Best Desmond John, Orlek Barry Sidney: Bicyclic benzamide compounds as histamine h3 receptor ligand useful in the treatment of neurological diseases. Glaxo Group, Best Desmond John, Orlek Barry Sidney, VALENTINE Jill Barbara, May 6, 2004: WO/2004/037788 (42 worldwide citation)

The present invention relates to novel bicyclic benzamide derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.


5
Kouichi Nakamichi, Shougo Izumi, Masaaki Oka: Method for inducing crystalline state transition in medicinal substance. Nippon Shinyaju, Graham & James, September 22, 1998: US05811547 (38 worldwide citation)

This invention has for its object to provide a method of inducing a transition in crystalline state of a crystallizable medicinal substance with great ease and improved efficiency and uniformity on a high production scale. According to the invention, an extruder is used for inducing a transition fro ...


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Hartog Jan, Wouters Wouter, Van Wijngaarden Ineke: Blood-pressure lowering piperazine derivatives.. Duphar Int Res, April 24, 1985: EP0138280-A2 (36 worldwide citation)

The invention relates to new piperazine derivatives of the formula wherein A is an optionally substituted bicyclic hetero aryl radical, n has the value 1 or 2, R1 and R2 are hydrogen or alkyl (1-3C). A is -CH2-CH2- or -CH(CH3)-CH2- and B is an optionally substituted aryl or hetero aryl group, an alk ...


8
Ostermayer Franz Dr, Zimmermann Markus Dr: 3-amino-1,2-propane diols, process for their preparation, pharmaceutical compositions containing them and use thereof.. Ciba-Geigy, September 17, 1980: EP0015505-A1 (31 worldwide citation)

Derivate des 3-Amino-1,2-propandiols der Formel in welcher Ar gegebenenfalls substituiertes Aryl, n die Zahl 0 oder 1 und alk Alkylen mit 2-5 Kohlenstoffatomen bedeuten, wobei das Stickstoffatom und das Sauerstoffatom oder, falls n für Null steht, der Phenylrest durch mindestens zwei Kohlenstoffatom ...


9
Gazit Ehud, Cohen Tomer: Compositions for treating amyloid associated diseases. Tel Aviv University Future Technology Development, Gazit Ehud, Cohen Tomer, G E EHRLICH, February 23, 2006: WO/2006/018850 (29 worldwide citation)

Indole derivatives, compositions including same, and methods utilizing same for the treatment of amyloid associated diseases, such as type II diabetes mellitus, Alzheimer's dementia or diseases, systemic and localized amyloidosis, and prion-related encephalopathies are provided.


10
Christopher A Demerson, Leslie G Humber, Thomas A Dobson, Ivo L Jirkovsky: 1,3,4,9-Tetrahydropyrano[3,4-b]indole-1-acetamides and derivatives. American Home Products Corporation, August 10, 1976: US03974179 (28 worldwide citation)

Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole or 1,3,4,9-tetrahydrothiopyrano[3,4-b]indole nucleus bearing a substituent in position 1, said substituent incorporating an acid, ester or amide function therein, are disclosed. The nucleus is further substituted at p ...