1
Pinkerton Anthony B, Davis Robert L, Gahman Timothy C, Semple Joseph E: Heterobicyclic and - tricyclic inhibitors of mapk/erk kinase. Kalypsys, Pinkerton Anthony B, Davis Robert L, Gahman Timothy C, Semple Joseph E, HO Raymond J, March 1, 2007: WO/2007/025090 (114 worldwide citation)

The present invention relates to compounds useful as inhibitors of MEK kinase and methods for the treatment or prevention of cellular proliferative disease states, such as conditions related to the hyperactivity of MEK, as well as diseases modulated by the MEK cascade.


2
Brooks Dee W, Summers James B: Indole-, benzofuran-, and benzothiophene-containing lipoxygenase-inhibiting compounds.. Abbott Lab, March 13, 1991: EP0416609-A2 (69 worldwide citation)

Pro-drugs of potent 5-lipoxygenase inhibiting compounds comprise compounds of the formula in which A is an alkylene or alkenylene group, X is oxygen, sulfur, sulfoxyl, or substituted nitrogen, and Y is a group which includes substituted or unsubstituted carbocyclic or substituted or unsubstituted he ...


3
Ross Barry Clive, Middlemiss David, Scopes David Ian Carter, Jack Torquil Iain Maclean, Cardwell Kevin Stuart, Dowle Michael Dennis: Indole derivatives.. Glaxo Group, May 29, 1991: EP0429257-A2 (62 worldwide citation)

The invention provides compounds of the general formula (I): or a physiologically acceptable salt or a solvate (e.g. hydrates) thereof in which R represents a hydrogen atom or a halogen atom or a group selected from C1-6 alkyl, C2-6 alkenyl, fluoroC1-6alkyl, -CHO, -CO2H or -COR; R represents a hydro ...


4
Beaulieu Pierre Louis, Brochu Christian, Chabot Catherine, Jolicoeur Eric, Kawai Stephen, Poupart Marc André, Tsantrizos Youla S: Viral polymerase inhibitors. Boehringer Ingelheim International, Boehringer Ingelheim Pharma & Co Kg, Beaulieu Pierre Louis, Brochu Christian, Chabot Catherine, Jolicoeur Eric, Kawai Stephen, Poupart Marc André, Tsantrizos Youla S, BERNIER Louise G, August 5, 2004: WO/2004/065367 (60 worldwide citation)

An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula (I): wherein wherein A, B, R2, R3, L, M1, M2, M3, M4, Y1, Y0, Z and Sp are as defined in claim 1, or a salt thereof, as an inhibitor of HCV NS5B polymerase.


5
Shankar Bandarpalle B, Rizvi Razia K, Kozlowski Joseph A, Shih Neng Yang: Cannabinoid receptor ligands. Schering Corporation, Shankar Bandarpalle B, Rizvi Razia K, Kozlowski Joseph A, Shih Neng Yang, BLINKA Thomas A, October 7, 2004: WO/2004/085385 (50 worldwide citation)

There are disclosed compounds of the formula (I) a pharmaceutically acceptable salt or solvate of the compound, which exhibit anti-inflammatory and immunomodulatory activity. Also disclosed are pharmaceutical compositions containing said compounds.


6
Bonnert Roger, Dickinson Mark, Rasul Rukhsana, Sanganee Hitesh, Teague Simon: Indole-3-sulphur derivatives. Astrazeneca, Bonnert Roger, Dickinson Mark, Rasul Rukhsana, Sanganee Hitesh, Teague Simon, ASTRAZENECA, January 22, 2004: WO/2004/007451 (48 worldwide citation)

The present invention relates to substituted indoles useful as pharmaceutical compounds for treating respiratory disorders. (I)


7
Bach Nicholas James, Dillard Robert Delane, Draheim Susan Elizabeth, Hermann Robert Bell, Schevitz Richard Walter: 1h-indole-3-acetamide derivatives as spla2 inhibitors.. Lilly Co Eli, October 19, 1994: EP0620215-A1 (48 worldwide citation)

A class of 1H-indole-3-acetamides, represented by the formula (I), and pharmaceutically acceptable salts thereof; is disclosed together with the use of such indole compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.


8
Azria Moise, Buchheit Karl Heinz, Dixon Keith Arnold, Engel Gunther, Giger Rudolf Karl Andreas: Therapeutic use of serotonin antagonists. Sandoz, February 17, 1988: GB2193633-A (48 worldwide citation)

Use of a mono or bicyclic carbocyclic, or heterocyclic carboxylic, acid ester or amide or an imidazolyl carbazol in the manufacture of a medicament suitable for the treatment of stress-related psychiatric disorders, for increasing vigilance, for the treatment of rhinitis or serotonin-induced disorde ...


9
Oxford Alexander William: An indole derivative. Glaxo Group, February 5, 1986: GB2162522-A (48 worldwide citation)

A compound of formula (I> and its physiologically acceptable salts and solvates are described as useful in treating and/or preventing pain resulting from dilation of the cranial vasculature, in particular migraine. The compound (I) may be prepared, for example, by cyclising a compound of formula (II ...


10
Miller Chris P, Tran Bach D, Collini Michael D: Estrogenic agents. American Home Prod, October 22, 1997: EP0802183-A1 (47 worldwide citation)

The present invention relates to new 2-Phenyl-1-Ä4-(2-Aminoethoxy)-BenzylÜ-Indole compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds, which have the general structures below: