1
Handa Balraj Krishan, Machin Peter James, Martin Joseph Armstrong, Redshaw Sally, Thomas Gareth John: Amino acid derivatives.. Hoffmann La Roche, December 20, 1989: EP0346847-A2 (262 worldwide citation)

Compounds of the formula wherein R represents alkoxycarbonyl, aralkoxycarbonyl, alkanoyl, cycloalkylcarbonyl, aralkanoyl, aroyl, heterocyclylcarbonyl, alkylsulphonyl, arylsulphonyl, monoaralkylcarbamoyl, cinnamoyl or alpha -aralkoxycarbonylaminoalkanoyl and R represents hydrogen or R and R together ...


2
Miguel Angel Ondetti, David W Cushman: Proline derivatives and related compounds. E R Squibb & Sons, Lawrence S Levinson, Merle J Smith, August 8, 1978: US04105776 (234 worldwide citation)

New proline derivatives and related compounds which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.


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Edward W Petrillo Jr: Phosphinylalkanoyl prolines. E R Squibb & Sons, Lawrence S Levinson, Merle J Smith, Stephen B Davis, September 18, 1979: US04168267 (118 worldwide citation)

New phosphinylalkanoyl prolines which have the general formula ##STR1## wherein R.sub.1 is lower alkyl, phenyl or phenyl-lower alkyl;


4
Rosenquist Åsa, Thorstensson Fredrik, Johansson Per Ola, Kvarnström Ingemar, Ayesa Susana, Classon Björn, Rakos Lazlo, Samuelsson Bertil: Hcv ns-3 serine protease inhibitors. Medivir, Tibotec Pharmaceuticals, Rosenquist Åsa, Thorstensson Fredrik, Johansson Per Ola, Kvarnström Ingemar, Ayesa Susana, Classon Björn, Rakos Lazlo, Samuelsson Bertil, AWAPATENT, August 11, 2005: WO/2005/073216 (105 worldwide citation)

Compounds of the formula (F) where the variables are as defined in the specification inhibit the NS3 protease of flavivirus sych as hepatitis C virus (HCV). The compounds comprise a novel linkage between a heterocyclic P2 unit and those portions of the inhibitor more distal to the nominal cleavage s ...


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Sunagawa Makoto Sumitomo Chemi, Matsumura Haruki Sumitomo Chem, Inoue Takaaki Sumitomo Chemica, Fukasawa Masatomo Sumitomo Che, Kato Masuhiro Sumitomo Chemica: Carboxylic thio-pyrrolidinyl beta-lactam compounds and production thereof.. Sumitomo Chemical Co, November 28, 1984: EP0126587-A1 (87 worldwide citation)

Penem compounds are of the formule: where R1 is H or hydroxyethyl, wherein the -OH may be protected R2 is H or a protective group, e.g. alkoxycarbonyl; R3 is H or a protective group, e.g. alkyl; X is methylene or alkyl-methylene or S; Y is amino (-NH2) which may be substituted by various groups whic ...


7
Roques Bernard: Derivatives of amino acids and their therapeutic use.. Roques Bernard, Schwartz Jean Charles, Lecomte Jeanne Marie, June 22, 1983: EP0082088-A1 (83 worldwide citation)

La présente invention est relative à de nouveaux dérivés répondant à la formule générale: les divers radicaux A, B, X, Z, R1, R2, R3,P et n ayant des définitions précisées. Ces composés ont notamment des activités inhibitrices de l'anképhalinase, antalgique, antidépressive, antidiarrhéique et hypote ...


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Hemmi Keiji, Neya Masahiro, Marusawa Hiroshi, Imai Keisuke, Kayakiri Natsuko, Hashimoto Masashi: New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same.. Fujisawa Pharmaceutical Co, January 25, 1989: EP0300189-A2 (80 worldwide citation)

A compound of the formula : wherein R is lower alkyl optionally substituted with a substituent selected from the group consisting of acyl,hydroxy, lower alkoxy, aryl, lower alkylthio and a group of the formula : in which R is hydrogen or acyl and R is hydrogen or lower alkyl; aryl; or amino optional ...


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Bailey Murray D, Bhardwaj Punit, Forgione Pasquale, Ghiro Elise, Goudreau Nathalie, Halmos Teddy, Llinas Brunet Montse, Poupart Marc André, Rancourt Jean: Hepatitis c inhibitor peptide analogs. Boehringer Ingelheim, International, Boehringer Ingelheim, Pharma & Co Kg, Bailey Murray D, Bhardwaj Punit, Forgione Pasquale, Ghiro Elise, Goudreau Nathalie, Halmos Teddy, Llinas Brunet Montse, Poupart Marc André, Rancourt Jean, BERNIER Louise G, January 5, 2006: WO/2006/000085 (76 worldwide citation)

The invention relates to compounds of formula (I) wherein R', R2, R3, R4, R5, R6, Y, n and m are as defined herein. The compounds are useful for the treatment and prevention of hepatitis C viral infections in mammals by inhibiting HCV NS3 protease. The invention further relates to azalactone compoun ...


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Vacca Joseph P, Holloway M Katharine, Dorsey Bruce D, Hungate Randall W, Guare James P: Hiv protease inhibitors useful for the treatment of aids.. Merck & Co, May 12, 1993: EP0541168-A1 (75 worldwide citation)

Compounds of formula where R and R are independently hydrogen or optionally-substituted C PI alkyl or aryl, or R and R are joined together to form a monocyclic or bicyclic ring system, are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in t ...