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Stéphane De Lombaert
Raymond F Horvath, Jennifer Tran, Stéphane De Lombaert, Kevin J Hodgetts, Philip A Carpino, David A Griffith: Certain alkylene diamine-substituted heterocycles. Neurogen Corporation, Pfizer, Ladas & Parry, January 14, 2003: US06506762 (111 worldwide citation)

The present invention also provides a general method to whereby mono-, bi-, or tricyclic heterocycles may be modified to obtain potent antagonists at the NPY


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James Doherty
Clifton John Blankley, Annette Marian Doherty, James Marino Hamby, Robert Lee Panek, Mel Conrad Schroeder, Howard Daniel Hollis Showalter, Cleo Connolly: 6-Aryl pyrido�2,3-d! pyrimidines and naphthyridines for inhibiting protein tyrosine kinase mediated cellular proliferation. Charles W Ashbrook, March 31, 1998: US05733913 (63 worldwide citation)

6-Aryl pyrido�2,3-d!pyrimidines and naphthyridines are inhibitors of protein tyrosine kinase, and are thus useful in treating cellular proliferation mediated thereby. The compounds are especially useful in treating atherosclerosis, restenosis, psoriasis, as well as bacterial infections.


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Stéphane De Lombaert
Rajagopal Bakthavatchalam, Charles A Blum, Harry L Brielmann, James William Darrow, Stéphane De Lombaert, Alan Hutchison, Jennifer Tran, Xiaozhang Zheng, Richard Louis Elliott, Marlys Hammond: Spiro[isobenzofuran-1,4′-piperidin]-3-ones and 3H-spiroisobenzofuran-1,4′-piperidines. Pfizer, Neurogen Corporation, Ladas & Parry, May 20, 2003: US06566367 (57 worldwide citation)

Substituted spiro[isobenzofuran-1,4′-piperidin]-3-ones and 3H-spiroisobenzofuran-1,4′-piperidines capable of modulating NPY5 receptor activity are provided. Such compounds may be used to modulate ligand binding to NPY5 receptors in vivo or in vitro, and are particularly useful in the treat ...


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Stéphane De Lombaert
Bakthavatchalam Rajagopal, Darrow James W, de, Lombaert Stéphane, Zheng Xiaozhang: Substituted pyridin-2-ylamine analogues. Neurogen Corporation, Bakthavatchalam Rajagopal, Darrow James W, de, Lombaert Stéphane, Zheng Xiaozhang, ALEXANDER John B, February 3, 2005: WO/2005/009980 (55 worldwide citation)

Substituted pyridin-2-ylamine analogues are provided, of the formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with patholog ...


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James Doherty
Clifton John Blankley, Diane Harris Boschelli, Annette Marian Doherty, James Marino Hamby, Sylvester Klutchko, Robert Lee Panek: Pyrido�2, 3-d!pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation. Warner Lambert Company, Charles W Ashbrook, March 31, 1998: US05733914 (48 worldwide citation)

6-Aryl pyrido�2,3-d!pyrimidine 7-imines, 7-ones, and 7-thiones are inhibitors of protein tyrosine kinases, and are thus useful in treating cellular proliferation mediated thereby. The compounds are especially useful in treating cancer, atherosclerosis, restenosis, and psoriasis.


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Craig Allen
Desaraju V Varaprasad, Mingtang Zhao, Craig Allen Dornan, Anoop Agrawal, Pierr Marc Allemand, Niall R Lynam: Electrochromic polymeric solid films, manufacturing electrochromic devices using such solid films, and processes for making such solid films and devices. Donnelly Corporation, Fitzpatrick Cella Harper & Scinto, February 15, 2005: US06855431 (43 worldwide citation)

The present invention relates to electrochromic polymeric solid films, manufacturing electrochromic devices using such solid films and processes for making such solid films and devices. The electrochromic polymeric solid films of the present invention exhibit beneficial properties and characteristic ...


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James Doherty
Clifton J Blankley, Diane H Boschelli, Annette M Doherty, James M Hamby, Sylvester Klutchko, Robert L Panek: Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation. Warner Lambert Company, Charles W Ashbrook, April 15, 1997: US05620981 (42 worldwide citation)

6-Aryl pyrido[2,3-d]pyrimidine 7-imines, 7-ones, and 7-thiones are inhibitors of protein tyrosine kinases, and are thus useful in treating cellular proliferation mediated thereby. The compounds are especially useful in treating cancer, atherosclerosis, restenosis, and psoriasis.


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James Doherty
Dorn Conrad P, Finke Paul E, Maccoss Malcolm, Doherty James B, Shah Shrenik K, Hagmann William K: New substituted azetidinones as anti-inflammatory and antidegenerative agents.. Merck & Co, April 22, 1992: EP0481671-A1 (40 worldwide citation)

New substituted azetidinones of the general formula (A') which have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents are described. e



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