1
Brent R Constantz, Bryan Barr, Kevin McVicker: Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite. Norian Corporation, Bertram I Rowland, October 1, 1991: US05053212 (168 worldwide citation)

Novel compositions are provided for the production of hydroxyapatite, where a dry mixture is provided which combines a calcium source and an acidic phosphate source, particularly monocalcium phosphate monohydrate or orthophosphoric acid crystals. These two are combined, optionally with other ingredi ...


2
Laurence C Chow, Shozo Takagi: Calcium phosphate hydroxyapatite precursor and methods for making and using the same. American Dental Association Health Foundation, Banner & Allegretti, June 4, 1996: US05522893 (135 worldwide citation)

Calcium phosphate compositions that are particularly useful and unique as orthopedic and dental cements and remineralizers, as well as methods and kits for their use, and the resulting products are disclosed. The compositions comprise tetracalcium phosphate which has been prepared from a mixture wit ...


3
Brent R Constantz, Bryan M Barr: Calcium phosphate cements comprising amorophous calcium phosphate. Norian Corporation, Bret E Field, Bozicevic & Reed, July 21, 1998: US05782971 (98 worldwide citation)

Calcium phosphate cements are provided. The subject cements comprise amorphous calcium phosphate, at least one additional calcium source, usually an additional calcium phosphate, and a liquid component, such as a physiologically acceptable lubricant. Upon combination of the cement components, a flow ...


4
Laurence C Chow, Shozo Takagi: Calcium phosphate hydroxyapatite precursor and methods for making and using the same. American Dental Association Health Foundation, Banner & Witcoff, December 9, 1997: US05695729 (89 worldwide citation)

Calcium phosphate compositions that are particularly useful and unique as orthopedic and dental cements and remineralizers, as well as methods and kits for their use, and the resulting products are disclosed. The compositions comprise tetracalcium phosphate which has been prepared from a mixture wit ...


5
Shigeo Niwa, Kazuhiko Sawai, Shinobu Takahashi, Mikiya Ono, Yoshiaki Fukuda, Hiroyasu Takeuchi, Hideo Tagai: Filler for filling in defects or hollow portions of bones. Mitsubishi Mining & Cement, Jordan and Hamburg, February 5, 1985: US04497075 (86 worldwide citation)

A filler for filling in defects or hollow portions of bones to coalesce with the bone tissues is provided which comprises powders of a calcium phosphate compound having the apatite crystalline structure of each crystallite size of 400 .ANG. or larger and of each crystal grain size of 3 .mu.m or smal ...


6
Shigeo Niwa, Kazuhiko Sawai, Shinobu Takahashi, Hideo Tagai, Mikiya Ono, Yoshiaki Fukuda, Hiroyasu Takeuchi: Method for filling in defects or hollow portions of bones. Mitsubishi Mining and Cement Company, Jordan and Hamburg, February 7, 1984: US04429691 (75 worldwide citation)

A filler for filling in defects or hollow portions of bones to coalesce with the bone tissues is provided which comprises powders of a calcium phosphate compound having the apatite crystalline structure of each crystal grain size of from 50 .orgate. to 10 microns and represented by the following gen ...


7
Dosuk D Lee, Christian Rey, Maria Aiolova: Synthesis of reactive amorphous calcium phosphates. Etex Corporation, Choate Hall & Stewart, July 22, 1997: US05650176 (74 worldwide citation)

The present invention provides a novel process for converting a standard inert amorphous calcium phosphate precipitate into highly reactive amorphous solids. The amorphous solids can be used to react with other calcium phosphate solids to form a poorly-crystalline synthetic hydroxyapatite that provi ...


8
Brent R Constantz, Bryan Barr, Kevin McVicker: Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite. Norian Corporation, Bertram I Rowland, January 12, 1993: US05178845 (73 worldwide citation)

Novel compositions are provided for the production of hydroxyapatite, where a dry mixture is provided which combines a calcium source and an acidic phosphate source, particularly monocalcium phosphate monohydrate or orthophosphoric acid crystals. These two are combined, optionally with other ingredi ...


9
Eugene W White: Calcium phosphate bone substitute materials. Interpore International, Cooper & Dunham, August 29, 1989: US04861733 (67 worldwide citation)

Calcium phosphates useful as bone substitute material or for the manufacture of prosthetic devices have been prepared from calcium hydroxyapatite material which has a uniformly permeable microporous structure characterized by a substantially uniform pore volume in the range from about 10 to about 90 ...


10
Dosuk D Lee, Christian Rey, Maria Aiolova, Ali Tofighi: Low temperature calcium phosphate apatite and a method of its manufacture. Etex Corporation, Choate Hall & Stewart, July 21, 1998: US05783217 (60 worldwide citation)

A method of preparing a low crystallinity calcium phosphate apatite is described in which a low crystallinity calcium phosphate is precipitated from an aqueous solution comprising calcium and phosphate ions; collected from the solution; and dehydrated in a humidity and at a temperature selected to m ...