1
Prabhu Mohapatra
Laxminarayan Bhat, Prabhu Prasad Mohapatra, Kouacou Adiey: Compositions, Synthesis, And Methods Of Using Piperazine Based Antipsychotic Agents. Reviva Pharmaceuticals, Fenwick & West, December 3, 2009: US20090298819-A1

The present invention provides novel piperazine derivatives which can be advantageously used for treating schizophrenia and related psychoses such as acute manic, bipolar disorder, autistic disorder and depression.


2
Prabhu Mohapatra
Laxminarayan Bhat, Prabhu P Mohapatra, Seema Rani Bhat: Compositions, Synthesis, and Methods of Using Quinolinone Based Atypical Antipsychotic Agents. Reviva Pharmaceuticals, Fenwick & West, November 27, 2008: US20080293736-A1

The present invention provides novel quinolinone derivatives which can be advantageously used for treating schizophrenia and related psychoses such as acute manic, bipolar disorder, autistic disorder, and depression.


3
Farina Marco, Gagliardi Stefania, Le, Poul Emmanuel, Palombi Giovanni, Rocher Jean Philippe: Novel heterocyclic compounds as positive allosteric modulators of metabotropic glutamate receptors. Addex Pharma, Farina Marco, Gagliardi Stefania, Le, Poul Emmanuel, Palombi Giovanni, Rocher Jean Philippe, DAVIES Jonathan Mark, December 7, 2006: WO/2006/129199 (109 worldwide citation)

The present invention relates to new compounds which are Heterocyclic derivatives of formula (I) wherein A, B, P, X, Y, Q, W, R1 and R2 are defined in the description. Invention compounds are useful for treating central or peripheral nervous system disorders and other disorders which are affected by ...


4
Strupczewski Joseph T, Helsley Grover C, Chiang Yulin, Bordeau Kenneth J: (aryloxyalkyl)Heteroarylpiperidines and -heteroarylpiperazines,a process for their preparation and their use as medicaments.. Hoechst Roussel Pharma, December 19, 1990: EP0402644-A1 (106 worldwide citation)

This invention related to compounds of the formula: wherein X is -O-, -S-, - @H, or -@-R; p is 1 or 2; Y is hydrogen, C1 to C6 alkyl, -OH, Cl, F, Br, I, C1 to C6 alkoxy, -CF3, NO2, or -NH2, when p is 1; Y is C1 to C6 alkoxy when p is 2 and X is -O-; R is selected from the group consisting of lower a ...


5
Oshlack Benjamin: Controlled release bases for pharmaceuticals.. Euro Celtique, January 20, 1988: EP0253104-A1 (105 worldwide citation)

The release of therapeutically active agents from controlled release bases is extended by using a combination of a higher aliphatic alcohol and an acrylic resin as the base material.


6
Strupczewski Joseph T: 3-(piperidinyl)- and 3-(pyrrolidinyl)-1h-indazoles, a process for their preparation and their use as a medicament.. Hoechst Roussel Pharma, April 3, 1985: EP0135781-A1 (103 worldwide citation)

Novel 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles, intermediates and processes for the preperation thereof, and their use for treating psychoses and alleviating pain are disclosed.


7
Barth Francis Res Saint James, Casellas Pierre, Congy Christian, Martinez Serge, Rinaldi Murielle, Anne Archard Gilles: Substituted n-piperidino 3-pyrazolecarboxamide.. Sanofi, June 7, 1995: EP0656354-A1 (99 worldwide citation)

N-Piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyra zole-3-carboxamide of formula: its salts and solvates are powerful antagonists of central cannabinoid receptors. They are prepared by reaction of a functional derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole- ...


8
Barth Francis St James Ap B, Casellas Pierre, Congy Christian, Martinez Serge, Carmona Murielle: Pyrazole derivatives, process for their preparation and pharmaceutical compositions containing them.. Sanofi Elf, December 29, 1993: EP0576357-A1 (98 worldwide citation)

The subject of the invention is pyrazole derivatives of formula I: in which - g2, g3, g4, g5, g6 and w2, w3, w4, w5 and w6 are identical or different and independently represent hydrogen, a chlorine or bromine atom, a (C1-C3)alkyl, a (C1-C3)alkoxy, a trifluoromethyl or a nitro group and g4 optionall ...


9
Andrieux Jean, Houssin Raymond, Yous Said Laboratoire de Chimi, Guardiola Beatrice, Lesieur Daniel: Naphthalene derivatives, procedure for their preparation and pharmaceutical compositions containing them.. Adir, September 18, 1991: EP0447285-A1 (96 worldwide citation)

Composés de formule générale : dans laquelle R, R1 et R2 sont définis dans la description. Les composés de formule (1) sont utiles dans le traitement de désordres de système nerveux central.


10
Baker Raymond, Macleod Angus Murray, Merchant Kevin John, Saunders John: Oxadiazoles useful in the treatment of senile dementia.. Merck Sharp & Dohme, September 30, 1987: EP0239309-A2 (92 worldwide citation)

A class of novel oxadiazoles, substituted on one of the ring carbon atoms with a non-aromatic azacyclic or azabicyclic ring, and substituted on the other ring carbon atom with a substituent of low lipophilicity; are potent muscarinic agonists, and have good CNS penetrability. The compounds are there ...