1
James Doherty
Dorn Conrad P, Finke Paul E, Maccoss Malcolm, Doherty James B, Shah Shrenik K, Hagmann William K: New substituted azetidinones as anti-inflammatory and antidegenerative agents.. Merck & Co, April 22, 1992: EP0481671-A1 (40 worldwide citation)

New substituted azetidinones of the general formula (A') which have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents are described. e


2
Bell Andrew Simon, Brown David, Terrett Nicholas Kenneth: Pyrazolopyrimidinone antianginal agents.. Pfizer, Pfizer, January 2, 1992: EP0463756-A1 (195 worldwide citation)

Compounds of the formula: wherein R is H, C1-C3 alkyl, C3-C5 cycloalkyl or C1-C3 perfluoroalkyl; R is H, C1-C6 alkyl optionally substituted by OH, C1-C3 alkoxy or C3-C6 cycloalkyl, or C1-C3 perfluoroalkyl; R is C1-C6 alkyl, C3-C6 alkenyl, C3-C6 alkynyl, C3-C7 cycloalkyl, C1-C6 perfluoroalkyl or (C3- ...


3
Chakravarty Prasun K, Greenlee William J, Mantlo Nathan B, Patchett Arthur A, Walsh Thomas F: Substituted imidazo-fused 6-membered heterocycles as angiotensin ii antagonists.. Merck & Co, December 5, 1990: EP0400974-A2 (191 worldwide citation)

Substituted Imidazo-fused 6-membered heterocycles of structural formula: wherein A, B, C, and D are independently carbon atoms or nitrogen atoms are angiotensin II antagonists useful in the treatment of hypertension and congestive heart failure.


4
Bru Magniez Nicole, Guengoer Timur, Lacrampe Jean, Launay Michele, Teulon Jean Marie: Benzimidazole and azabenzimidazole derivatives, process for their preparation, synthesis intermediates, pharmaceutical compositions containing them, useful for the treatment of cardiovascular diseases and duodenal ulcers.. Union Pharma Scient Appl, September 5, 1990: EP0385850-A2 (114 worldwide citation)

The invention relates to the products of formula: and their tautomeric forms, in which formula: -Y is located at position 4, 5, 6 or 7 of the benzimidazole or azabenzimidazole ring-system and represents an imidazole, benzimidazole, triazole or imidazothiazole derivative which can be substituted or o ...


5
Vandenberk Jan, Kennis Ludo Edmond Josephine, Van Der Aa Marcel Josef Maria, Van Heertum Albert Henricus Ma: (Piperidinylalkyl)Quinazoline derivatives, process for their preparation and pharmaceutical compositions containing them.. Janssen Pharmaceutica, July 23, 1980: EP0013612-A2 (108 worldwide citation)

Quinazoline derivatives of the formula wherein Ra is hydrogen or alkyl and and q is 2 or 3; R is hydorgen, hydroxy and alkyl; Alk is an alkylene chain having from 1 to 4 carbon atoms and Q is a quinazolinyl radical, the 1-, 2-, 3- or 4-position of which is connected with the alkylene side chain, sai ...


6
Coates William John, Flynn Seyn Thomas, Rawlings Derek Anthony: Fused pyrimidine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them.. Smith Kline French Lab, December 20, 1989: EP0347146-A2 (101 worldwide citation)

Compounds of the formula (1) : or pharmaceutically acceptable salts thereof as described, wherein is a pyridine, pyrazine or triazine ring; R is C1-6alkyl, C2-6alkenyl, C3-5cycloalkylC1-6alkyl, or C1-6alkyl substituted by 1 to 6 fluoro groups; R is C1-6alkylthio, C1-6alkylsulphonyl, C1-6alkoxy, hydr ...


7
Coates William John: Purine compounds, process for their preparation and pharmaceutical compositions.. Smith Kline French Lab, January 31, 1990: EP0352960-A2 (99 worldwide citation)

Compounds of the formula (1): and pharmaceutically acceptable salts thereof, wherein R is C1-6alkyl, C2-6alkenyl, C3-5cycloalkylC1-4alkyl, phenylC1-4alkyl or C1-4alkyl substituted by 1 to 6 fluoro groups; R is hydrogen, hydroxy, C1-4alkyl, phenyl, mercapto, C1-4alkylthio, CF3 or amino; R is hydrogen ...


8
Murugesan Natesan, Hunt John T: Phenyl sulfonamide and their use as endothelin antagonists.. Squibb & Sons, November 10, 1993: EP0569193-A1 (98 worldwide citation)

Compounds of the formula inhibit the activity of endothelin. The symbols are defined as follows: one of X and Y is N and the other is O; R, R and R are each independently is other than hydrogen; , Z and Z; ; ; , -S(O)m-OH, -S(O)m-OR, -O-S(O)m-R, -O-S(O)mOH, or -O-S(O)m-OR; -NRR; or -N(R)-Z-NRR; and ...


9
Bell Andrew Simon, Terrett Nicholas Kenneth: Pyrazolopyrimidinone antianginal agents.. Pfizer, Pfizer, February 3, 1993: EP0526004-A1 (92 worldwide citation)

Compounds of formula: and pharmaceutically acceptable salts thereof, wherein R is H; C1-C3 alkyl optionally substituted with one or more fluoro substituents; or C3-C5 cycloalkyl; R is H, or C1-C6 alkyl optionally susbtituted with one or more fluoro subtituents or with C3-C6 cycloalkyl; R is C1-C6 al ...


10
Mitchell Robert Dempster, Skwish Stephen: Composition comprising heparin and rapamycin.. American Home Prod, November 3, 1993: EP0568310-A1 (91 worldwide citation)

This invention concerns a combination of rapamycin and heparin in preventing or treating hyperproliferative vascular disease in a mammal.