1
Browne Leslie J Dr: Substituted imidazo(1,5-a)pyridines.. Ciba-Geigy, August 1, 1984: EP0114572-A1 (158 worldwide citation)

Die vorliegende Erfindung betrifft Verbindungen der Formel I oder ihre 5,6,7,8-Tetrahydroderivate, worin R1 für Wasserstoff, Halogen, Niederalkyl, Niederalkoxy, Hydroxy oder Aryl-niederalkoxy steht, R2 Wasserstoff, Halogen oder Niederalkyl bedeutet, A für Alkylen mit 1 bis 12 Kohlenstoffatomen, Alki ...


2
Kolb Michael, Burkhart Joseph P, Jung Michel J, Gerhart Fritz E, Giroux Eugene L, Schirlin Daniel G, Neises Bernhard: Novel peptidase inhibitors.. Merrell Dow Pharma, September 24, 1986: EP0195212-A2 (127 worldwide citation)

This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone moiety. These analogs of the peptidase substrates provide specific enzyme inhibitors for a variety of ...


3
Eury Robert P, Garguilo Darlene, Villareal Plaridel: Method of incorporating drugs into a polymer component of stents. Advanced Cardiovascular System, October 2, 1996: EP0734721-A2 (124 worldwide citation)

The drug-loaded polymeric material containing a therapeutic drug can be applied to a structure of an intravascular stent. A therapeutically effective amount of a therapeutic drug is incorporated into such a layer of polymeric material, without significantly increasing the thickness of the stent, to ...


4
Kettner Charles Adrian, Shenvi Ashokkumar Bhikkappa: Peptide boronic acid inhibitors of trypsin-like proteases.. Du Pont, December 7, 1988: EP0293881-A2 (124 worldwide citation)

Peptides comprising C-terminal boronic acid derivatives of lysine, ornithine, and arginine, homoarginine and corresponding isothiouronium analogs thereof, of the formula are reversible inhibitors of trypsin-like serine proteases such as thrombin, plasma kallikrein and plasmin.


5
Kimball Spencer D, Das Jagabandhu, Lau Wan Fang: Sulfonamido heterocyclic thrombin inhibitors.. Squibb Bristol Myers Co, June 15, 1994: EP0601459-A2 (115 worldwide citation)

Sulfonamido heterocyclic thrombin inhibitors are provided which have the structure wherein G is including all stereoisomers thereof and salts thereof, wherein n is 0, l or 2 or 3; m is 0, l, 2 or 3; Y is NH or S; p is 0, l or 2, Q is a single bond or A is aryl, cycloalkyl, azacycloalkyl or azahetero ...


6
Bru Magniez Nicole, Guengoer Timur, Lacrampe Jean, Launay Michele, Teulon Jean Marie: Benzimidazole and azabenzimidazole derivatives, process for their preparation, synthesis intermediates, pharmaceutical compositions containing them, useful for the treatment of cardiovascular diseases and duodenal ulcers.. Union Pharma Scient Appl, September 5, 1990: EP0385850-A2 (114 worldwide citation)

The invention relates to the products of formula: and their tautomeric forms, in which formula: -Y is located at position 4, 5, 6 or 7 of the benzimidazole or azabenzimidazole ring-system and represents an imidazole, benzimidazole, triazole or imidazothiazole derivative which can be substituted or o ...


7
Egbertson Melissa S, Hartman George D, Halczenko Wasyl, Laswell William L: Novel fibrinogen receptor antagonists.. Merck & Co, April 1, 1992: EP0478328-A1 (101 worldwide citation)

A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation.


8
Goeddel David Vannorman, Kohr William Jack, Pennica Diane, Vehar Gordon Allen: Human tissue plasminogen activator, pharmaceutical compositions containing it, processes for making it, and dna and transformed cell intermediates therefor.. Genentech, November 9, 1983: EP0093619-A1 (101 worldwide citation)

Human tissue plasminogen activator (t-PA) is produced in useful quantities using recombinant techniques. This invention thus enables production of t-PA free of contaminants associated with it in its native cellular environment. Methods, expression vehicles and various host cells useful in its produc ...


9
Barth Francis Res Saint James, Casellas Pierre, Congy Christian, Martinez Serge, Rinaldi Murielle, Anne Archard Gilles: Substituted n-piperidino 3-pyrazolecarboxamide.. Sanofi, June 7, 1995: EP0656354-A1 (99 worldwide citation)

N-Piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyra zole-3-carboxamide of formula: its salts and solvates are powerful antagonists of central cannabinoid receptors. They are prepared by reaction of a functional derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole- ...


10
Inamura Kazue, Kanaya Naoaki, Nagahara Takayasu, Yokoyama Yukio: Aromatic amidine derivatives and salts thereof.. Daiichi Seiyaku Co, May 5, 1993: EP0540051-A1 (99 worldwide citation)

An anticoagulant agent which comprises, as an active ingredient, an aromatic amidine derivative represented by the following general formula (1) or a salt thereof: wherein the group represented by is a group selected from indolyl, benzofuranyl, benzothienyl, benzimidazolyl, benzoxazolyl, benzothiazo ...