Boss Michael Alan, Kenten John Henry, Emtage John Spencer, Wood Clive Ross: Processes for the production of multichain polypeptides or proteins.. Celltech, October 3, 1984: EP0120694-A2 (276 worldwide citation)

This invention relates to multichain polypeptides or proteins and processes for their production in cells of host organisms which have been transformed by recombinant DNA techniques. According to a first aspect of the present invention, there is provided a process for producing a heterologous multic ...

Patchett Arthur A, Harris Elbert E, Wyvratt Matthew J, Tristram Edward W: Carboxyalkyl dipeptide derivatives, process for preparing them and pharmaceutical composition containing them.. Merck & Co, June 25, 1980: EP0012401-A1 (181 worldwide citation)

Carboxyalkyl dipeptide derivatives and related compounds which are useful as antihypertensives, and having the formulae: wherein R and R are the same or different and are hydroxy, alkoxy, alkenoxy, dialkylamino alkoxy, acylamino alkoxy, acyloxy alkoxy, aryloxy, alkyloxy, substituted aryloxy or subst ...

Browne Leslie J Dr: Substituted imidazo(1,5-a)pyridines.. Ciba-Geigy, August 1, 1984: EP0114572-A1 (158 worldwide citation)

Die vorliegende Erfindung betrifft Verbindungen der Formel I oder ihre 5,6,7,8-Tetrahydroderivate, worin R1 für Wasserstoff, Halogen, Niederalkyl, Niederalkoxy, Hydroxy oder Aryl-niederalkoxy steht, R2 Wasserstoff, Halogen oder Niederalkyl bedeutet, A für Alkylen mit 1 bis 12 Kohlenstoffatomen, Alki ...

Weidmann Beat: Hydrophilic renin inhibitors. Sandoz, May 24, 1989: GB2209752-A (137 worldwide citation)

L'invention a pour objet les inhibiteurs hydrophiles de la rénine, en particulier les composés de formule :(CF DESSIN DANS BOPI)dans laquelle W signifie -O-, -NR2 - ou -CH2 -, R1 signifie des restes organiques variés et A, B, C et D signifient une liaison ou des restes organiques variés.

Kettner Charles Adrian, Shenvi Ashokkumar Bhikkappa: Peptide boronic acid inhibitors of trypsin-like proteases.. Du Pont, December 7, 1988: EP0293881-A2 (124 worldwide citation)

Peptides comprising C-terminal boronic acid derivatives of lysine, ornithine, and arginine, homoarginine and corresponding isothiouronium analogs thereof, of the formula are reversible inhibitors of trypsin-like serine proteases such as thrombin, plasma kallikrein and plasmin.

Lauffer Leander Dr, Oquendo Patricia Dr, Zettlmeissl Gerd Dr, Seed Brian Dr: Fusionproteins with parts of immunoglobulins, their production and use.. Behringwerke, Gen Hospital, January 8, 1992: EP0464533-A1 (123 worldwide citation)

The invention relates to genetically engineered soluble fusion proteins consisting of human proteins or parts thereof not belonging to the immunoglobulin family and various portions of the constant region of immunoglobulin molecules. The functional properties of both fusion components are surprising ...

Edwardson Peter Andrew David, Fairbrother John Esam, Gardner Ronald Stephen, Hollingsbee Derek Andrew, Cederholm Williams Stuart Anth: Fibrin sealant compositions and method for utilizing same.. Squibb & Sons, April 13, 1994: EP0592242-A1 (117 worldwide citation)

The subject invention relates to fibrin sealants. More specifically, the subject invention relates to the use of a fibrin sealant wherein a composition comprising fibrin monomer or a composition comprising noncrosslinked fibrin is utilized as a component of the fibrin sealant.

Kimball Spencer D, Das Jagabandhu, Lau Wan Fang: Sulfonamido heterocyclic thrombin inhibitors.. Squibb Bristol Myers Co, June 15, 1994: EP0601459-A2 (115 worldwide citation)

Sulfonamido heterocyclic thrombin inhibitors are provided which have the structure wherein G is including all stereoisomers thereof and salts thereof, wherein n is 0, l or 2 or 3; m is 0, l, 2 or 3; Y is NH or S; p is 0, l or 2, Q is a single bond or A is aryl, cycloalkyl, azacycloalkyl or azahetero ...

Bru Magniez Nicole, Guengoer Timur, Lacrampe Jean, Launay Michele, Teulon Jean Marie: Benzimidazole and azabenzimidazole derivatives, process for their preparation, synthesis intermediates, pharmaceutical compositions containing them, useful for the treatment of cardiovascular diseases and duodenal ulcers.. Union Pharma Scient Appl, September 5, 1990: EP0385850-A2 (114 worldwide citation)

The invention relates to the products of formula: and their tautomeric forms, in which formula: -Y is located at position 4, 5, 6 or 7 of the benzimidazole or azabenzimidazole ring-system and represents an imidazole, benzimidazole, triazole or imidazothiazole derivative which can be substituted or o ...

Chakravarty Prasun K, Patchett Arthur A, Camara Valerie J, Walsh Thomas F, Greenlee William J: Substituted benzimidazoles as angiotensin ii antagonists.. Merck & Co, December 5, 1990: EP0400835-A1 (113 worldwide citation)

There are disclosed new substituted benzimidazole compounds and derivatives thereof which are useful as angiotensin II antagonists. These compounds have the general formula: l