1
Ruxandra Gref, Yoshiharu Minamitake, Robert S Langer: Biodegradable injectable nanoparticles. Massachusetts Institute of Technology, Arnall Golden & Gregory, August 6, 1996: US05543158 (386 worldwide citation)

Particles are provided that are not rapidly cleared from the blood stream by the macrophages of the reticuloendothelial system, and that can be modified to achieve variable release rates or to target specific cells or organs. The particles have a biodegradable solid core containing a biologically ac ...


2
Mahesh V Patel, Feng Jing Chen: Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents. Lipocine, Dianne E Reed, Reed & Associates, September 25, 2001: US06294192 (363 worldwide citation)

The present invention relates to triglyceride-free pharmaceutical compositions for delivery of hydrophobic therapeutic agents. Compositions of the present invention include a hydrophobic therapeutic agent and a carrier, where the carrier is formed from a combination of a hydrophilic surfactant and a ...


3
Abraham J Domb, Ruxandra Gref, Yoshiharu Minamitake, Maria Teresa Peracchia, Robert S Langer: Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers. Massachusetts Institute of Technology, Arnall Golden & Gregory, December 28, 1999: US06007845 (332 worldwide citation)

Particles are provided that are not rapidly cleared from the blood stream by the macrophages of the reticuloendothelial system, and that can be modified to achieve variable release rates or to target specific cells or organs. The particles have a core of a multiblock copolymer formed by covalently l ...


4
Ramachandran Radhakrishnan, Paul J Mihalko, Robert M Abra: Method and apparatus for administering dehydrated liposomes by inhalation. Liposome Technology, Peter J Dehlinger, January 23, 1990: US04895719 (267 worldwide citation)

A system and method for administering a drug, at a selected dose, via the respiratory tract. Spray-dried liposome particles containing the selected dose of the entrapped drug are released into the air in aerosolized form, either by entrainment in an air or propellant stream, or by release from a pre ...


5
Robert F Kaiko, Robert D Colucci: Opioid agonist/opioid antagonist/acetaminophen combinations. Euro Celtique, Davidson Davidson & Kappel, April 23, 2002: US06375957 (237 worldwide citation)

The invention is directed in part to oral dosage forms comprising a combination of an opioid agonist, acetaminophen and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the ...


6
Ramesh C Rathi, Gaylen M Zentner: Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties. MacroMed, Thorpe North & Western, December 21, 1999: US06004573 (227 worldwide citation)

A water soluble biodegradable ABA-type block copolymer made up of a major amount of hydrophobic poly(lactide-co-glycolide) copolymer A-blocks and a minor amount of a hydrophilic polyethylene glycol polymer B-block, having an overall average molecular weight of between about 3100 and 4500, possesses ...


7
Ashok J Desai: Oral compositions of proteinaceous medicaments. Applied Analytical, William H Edgerton, April 27, 1993: US05206219 (196 worldwide citation)

Proteinaceous medicaments such as erythropoetin, insulin and calcitonin are formulated in a medium comprising a polyol pharmaceutical solvent combined as co-solvent with a lipid pharmaceutical solvent. The formulation is adapted for oral administration as a liquid as well as a filled hard or soft ge ...


8
Neil P Desai, Patrick Soon Shiong, Paul A Sandford, Mark W Grinstaff, Kenneth S Suslick: Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor. VivoRx Pharmaceuticals, Stephen E Pretty Schroeder Brueggemann & Clark Reiter, August 8, 1995: US05439686 (194 worldwide citation)

In accordance with the present invention, there are provided compositions for the in vivo delivery of substantially water insoluble pharmacologically active agents (such as the anticancer drug taxol) in which the pharmacologically active agent is delivered in a soluble form or in the form of suspend ...


9
Hao Zhang, Jed Croft: Oral transmucosal drug dosage using solid solution. Anesta Corporation, Michael F Krieger, Kirton & McConkie, July 24, 2001: US06264981 (174 worldwide citation)

The present invention is directed toward formulation and method for oral transmucosal delivery of a pharmaceutical. The invention provides a drug formulation comprising a solid pharmaceutical agent in solid solution with a dissolution agent. The formulation is administered into a patient's oral ...


10
John W Shell: Sustained-release oral drug dosage form. DepoMed Systems, Irell & Manella, April 16, 1991: US05007790 (168 worldwide citation)

Sustained-release oral drug-dosage forms that release drug in solution at a rate controlled by the solubility of the drug are described. The dosage form comprises a tablet or capsule which comprises a plurality of particles of a dispersion of a limited solubility drug in a hydrophilic, water-swellab ...