1
George N Paradissis, James A Garegnani, Roy S Whaley: Extended release pharmaceutical formulations. KV Pharmaceutical Company, Gary M Nath, August 29, 1995: US05445829 (179 worldwide citation)

An extended release pharmaceutical formulation adapted to approach zero order release of drug over a 12 to at least 24 hour period, comprised of a mixture of 0 to about 50% of an immediate release particle containing a drug, inert substrate and binder, coated with talc and up to 100% of an extended ...


2
Angelo M Morella, Mark C Fisher: Sustained release pharmaceutical composition. F H Faulding & Co, Darby & Darby, July 19, 1994: US05330766 (154 worldwide citation)

The present invention relates to a pharmaceutical pellet composition having a core element including at least one highly soluble active ingredient and a core coating which is partially soluble at a highly acidic pH. The pharmaceutical composition provides a slow release of active ingredient at a hig ...


3
Yegnaswami Raghunathan: Prolonged release pharmaceutical preparations. Pennwalt Corporation, September 9, 1980: US04221778 (117 worldwide citation)

Prolonged release pharmaceutical preparations containing ion exchange resin drug complexes at least a substantial portion of which have been treated with a solvating agent and provided with a diffusion barrier coating.


4
John R Howard, Peter Timmins: Controlled release formulation. E R Squibb & Sons, Lawrence S Levinson, Burton Rodney, December 20, 1988: US04792452 (108 worldwide citation)

A controlled release pharmaceutical formulation is provided which releases a pharmaceutical of a basic character at a controlled rate regardless of the pH of the environment, which formulation includes a basic pharmaceutical, up to about 45% by weight of a pH dependent polymer which is a salt of alg ...


5
Elie S Nuwayser, William A Nucefora: Composite core coated microparticles and process of preparing same. Biotek, Richard P Crowley, February 4, 1986: US04568559 (107 worldwide citation)

A process for preparing coated microparticles, which process comprises preparing a solvent solution of an active ingredient to be encapsulated and a film-forming polymer, removing the solvent to provide a dry, composite, uniform admixture of the active ingredient and the polymer material, reducing t ...


6
Garry L Porter: Composition and method to prevent accidental and intentional overdosage with psychoactive drugs. John H Widdowson, November 20, 1979: US04175119 (101 worldwide citation)

A composition and method of inducing emesis to preclude death from accidental or intentional overdosage of a therapeutic composition. The surface of the therapeutic composition is coated with an emetic chemical of such quantity that if the therapeutic composition is consumed in moderation or in acco ...


7
David L Berliner, Sergio Nacht: Delivery of drugs to the lower gastrointestinal tract. Advanced Polymer Systems, Heller Ehrman White & McAuliffe, December 15, 1998: US05849327 (95 worldwide citation)

Diseases of the colon are treated by oral ingestion of a unit dosage form containing a plurality of porous microscopic beads, the pores containing an active agent or drug and plugged with a polysaccharide that is chemically degradable by colon-specific bacteria. The dosage form further contains a co ...


8
Garry L Porter: Composition and method for protecting a therapeutic drug. Clear Lake Development Group, July 3, 1984: US04457907 (94 worldwide citation)

A therapeutic composition comprising a therapeutic drug that can cause undesirable effects on the pre-intestinal phases when contacting these phases, and an enteric coating surrounding the drug. A method for protecting a therapeutic drug including forming an enteric coating around the drug.


9
Elie S Nuwayser, William A Nucefora: Controlled release composite core coated microparticles. Biotek, Richard P Crowley, November 18, 1986: US04623588 (90 worldwide citation)

A process for preparing coated microparticles, which process comprises preparing a solvent solution of an active ingredient to be encapsulated and a film-forming polymer, removing the solvent to provide a dry, composite, uniform admixture of the active ingredient and the polymer material, reducing t ...


10
Jerry D Childers, George V Guittard, Glen E Barclay, Anthony L Kuczynski, Patrick S L Wong: Hydrocodone therapy. ALZA Corporation, Paul Sabatine, Susan K Thomas, Michael J Rafa, February 2, 1999: US05866161 (84 worldwide citation)

A hydrocodone composition, a hydrocodone dosage form, and a method of administering hydrocodone are disclosed and indicated for hydrocodone therapy.