41
Amarpreet S Sawhney, Peter G Edelman: Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use. Incept, Patterson Thuente Skaar & Christensen P A, March 9, 2004: US06703047 (165 worldwide citation)

Compositions and methods are provided for forming tissue-adherent hydrogels using substantially dry precursors. The dehydrated precursors are premixed prior to in situ therapy and utilize naturally-occurring body fluids as an aqueous environment that initiates transformation, which causes dissolutio ...


42
Robert S Goldie, Sandra T A Malkowska, Stewart T Leslie, Ronald B Miller: Controlled release dihydrocodeine composition. Euroceltique, Steinberg & Raskin, May 30, 1989: US04834984 (164 worldwide citation)

A solid controlled release, oral dosage form, the dosage form comprising an analgesically effective amount of dihydrocodeine or a salt thereof in a controlled release matrix wherein the dissolution rate in vitro of the dosage form, when measured by the USP Paddle Method at 100 rpm in 900 ml aqueous ...


43
Ronald Brown Miller, Stewart Thomas Leslie, Sandra Therese Antoinette Malkowska, Treavor John Knott, Deborah Challis, Derek Allan Prater, Joanne Heafield: Pharmaceutical multiparticulates. Euro Celtique, Davidson Davidson & Kappel, April 6, 1999: US05891471 (162 worldwide citation)

A process for the manufacture of particles comprises mechanically working a mixture of a drug and a hydrophobic and/or hydrophilic fusible carrier in a high speed mixture so as to form agglomerates, breaking the agglomerates to give controlled release particles and optionally continuing the mechanic ...


44
Donald A Tomalia, James R Baker, Roberta C Cheng, Anna U Bielinska, Michael J Fazio, David M Hedstrand, Jennifer A Johnson, Donald A Kaplan deceased, Scott L Klakamp, William J Kruper Jr, Jolanta Kukowska Latallo, Bartley D Maxon, Lars T Piehler, Ian A Tomlinson, Larry R Wilson, Rui Yin, Herbert M Brothers II: Bioactive and/or targeted dendrimer conjugates. The Dow Chemical Company, Dendritech Incorporated, The Regents of the University of Michigan, Karen L Kimble, February 3, 1998: US05714166 (159 worldwide citation)

Dendritic polymer conjugates which are composed of at least one dendrimer in association with at least one unit of a carried material, where the carrier material can be a biological response modifier, have been prepared. The conjugate can also have a target director present, and when it is present t ...


45
L Brian Starling, James E Stephan: Calcium phosphate microcarriers and microspheres. CaP Biotechnology, Sheridan Ross P C, April 3, 2001: US06210715 (157 worldwide citation)

The present invention provides calcium phosphate-based (CAP) microcarriers and microspheres and their use in cell culturing systems, chromatography and implantable biomedical materials.


46
Joanne Heafield, Trevor John Knott, Stewart Thomas Leslie, Sandra Therese Antoinette Malkowska, Ronald Brown Miller, Derek Allan Prater, Kevin John Smith: Sustained release compositions of morphine and a method of preparing pharmaceutical compositions. Euro Celtique, Davidson Davidson & Kappel, March 9, 1999: US05879705 (157 worldwide citation)

Sustained release pharmaceutical formulations containing morphine, or a pharmaceutically acceptable salt thereof, as active ingredient, suitable for administration on a once daily basis, are disclosed. In a first aspect, an orally administrable sustained release unit dosage form gives a peak plasma ...


47
Tsuneji Nagai, Yoshiharu Machida, Yoshiki Suzuki, Hiroshi Ikura: Method and preparation for administration to the mucosa of the oral or nasal cavity. Teijin, Wenderoth Lind & Ponack, October 7, 1980: US04226848 (157 worldwide citation)

A method for administering a medicament which comprises adhering to the mucosa of the oral or nasal cavity a pharmaceutical preparation comprising


48
Randall T Sparks, Edward J Geoghegan: Controlled release powder and process for its preparation. Elan Corporation, Robert H Falk, Henry Croskell, July 10, 1990: US04940588 (156 worldwide citation)

A controlled release powder containing discrete micro-particles for use in edible, pharmaceutical and other controlled release compositions is disclosed. The micro-particles have an average size in the range of from 0.1 to 125 .mu.m. Each of the micro-particles is in the form of a micromatrix of an ...


49
Paul D Kemp, Robert M Carr Jr, John G Maresh: Collagen constructs. Organogenesis, David G Conlin, Linda M Buckley, October 26, 1993: US05256418 (155 worldwide citation)

The present invention provides collagen constructs and methods of making and using such constructs. The present invention also provides tissue equivalents having improved characteristics and methods of making and using such tissue equivalents. This invention also provides methods of producing highly ...


50
David A Edwards, Giovanni Caponetti, Jeffrey S Hrkach, Noah Lotan, Justin Hanes, Abdell Aziz Ben Jebria, Robert S Langer: Aerodynamically light particles for pulmonary drug delivery. Massachusetts Institute of Technology, Penn State Research Foundation, Hamilton Brook Smith & Reynolds P C, October 24, 2000: US06136295 (154 worldwide citation)

Improved aerodynamically light particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of a biodegradable material and have a tap density less than 0.4 g/cm.sup.3 and ...