1
Evan C Unger, Thomas A Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu: Therapeutic drug delivery systems. ImaRx Pharmaceutical, Woodcock Washburn Kurtz Mackiewicz & Norris, December 3, 1996: US05580575 (298 worldwide citation)

Therapeutic drug delivery systems comprising gas-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic drug delivery applications are also provided. Drug delivery systems comprising gas-filled liposomes having encapsulated therein a drug a ...


2
Evan C Unger, Thomas A Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu: Therapeutic delivery systems related applications. ImaR sub x Pharmaceutical, Woodcock Washburn Kurtz Mackiewicz & Norris, August 6, 1996: US05542935 (263 worldwide citation)

Therapeutic delivery systems comprising gaseous precursor-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided. Therapeutic delivery systems comprising gaseous precursor-filled liposomes having enca ...


3
Mark W Grinstaff, Patrick Soon Shiong, Michael Wong, Paul A Sandford, Kenneth S Suslick, Neil P Desai: Composition useful for in vivo delivery of biologics and methods employing same. Vivorx Pharmaceuticals, Stephen E Pretty Schroeder Brueggemann & Clark Reiter, March 12, 1996: US05498421 (260 worldwide citation)

In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a biocompatible material. The biologic can be associated with the polymeric shell itself, and/or the biol ...


4
Evan C Unger, Terry O Matsunaga, David Yellowhair: Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles. ImaRx Pharmaceutical, Woodcock Washburn Kurtz Mackiewicz & Norris, March 31, 1998: US05733572 (255 worldwide citation)

Gas and gaseous precursor filled microspheres, and foams thereof, provide novel topical and subcutaneous delivery vehicles for various active ingredients, including drugs and cosmetics.


5
Marcel B Bally, Nancy L Boman, Pieter R Cullis, Lawrence D Mayer: Liposomal compositions for enhanced retention of bioactive agents. Inex Pharmaceuticals Corporation, University of British of Columbia, Townsend and Townsend and Crew, January 21, 1997: US05595756 (240 worldwide citation)

Liposomal compositions encapsulating bioactive agents and having improved circulation longevity of the agents are disclosed. Such liposomes combine a low pH of the solution in which a bioactive agent is entrapped and a sugar-modified lipid or an amine-bearing lipid, the combination of which enhances ...


6
Robert J Suhadolnik, Wolfgang Pfleiderer: Encapsulated 2,5-phosphorothioate oligoadenylates. Temple University of the Commonwealth System of Higher Education, Seidel Gonda Lavorgna & Monaco, February 23, 1993: US05188897 (238 worldwide citation)

Optically active compounds of the formula ##STR1## wherein n is 1 or 2 and m is 0, 1, 2 or 3 have antiviral activity. Compounds of the formula wherein at least one of the internucleotide phosphorothioate linkages is


7
Evan C Unger, Thomas A Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu: Method of preparing gas and gaseous precursor-filled microspheres. ImaRx Pharmaceutical, Woodcock Washburn Kurtz Mackiewicz & Norris, December 17, 1996: US05585112 (215 worldwide citation)

Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.


8
Evan C Unger, Thomas A Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu: Therapeutic drug delivery systems. ImaRx Pharmaceutical, Woodcock Washburn Kurtz Mackiewicz & Norris, June 23, 1998: US05770222 (211 worldwide citation)

Therapeutic drug delivery systems comprising gas-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic drug delivery applications are also provided. Drug delivery systems comprising gas-filled liposomes having encapsulated therein a drug a ...


9
Francis J Martin, Martin C Woodle, Carl Redemann, Annie Yau Young: Solid tumor treatment method and composition. Liposome Technology, Peter J Dehlinger, May 25, 1993: US05213804 (207 worldwide citation)

A liposome composition for localizing an anti-tumor compound to a solid tumor via the bloodstream. The liposomes, which contain the agent in entrapped form, are composed of vesicle-forming lipids and between 1-20 mole percent of a vesicle-forming lipid derivatized with hydrophilic biocompatible poly ...


10
Richard Rox Anderson: Targeting of sebaceous follicles as a treatment of sebaceous gland disorders. The General Hospital Corporation, Scott Rothenberger, Nutter McClennen & Fish, February 6, 2001: US06183773 (186 worldwide citation)

Laser treatments of sebaceous gland disorders with laser sensitive dyes are disclosed. A preferred laser treatment includes topical application of an energy activatable material to the skin followed by laser irradiation.