1
Darrell R Anderson, Nabil Hanna, John E Leonard, Roland A Newman, Mitchell E Reff, William H Rastetter: Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma. IDEC Pharmaceuticals Corporation, Burns Doane Swecker & Mathis, July 7, 1998: US05776456 (187 worldwide citation)

Disclosed herein are therapeutic treatment protocols designed for the treatment of B cell lymphoma. These protocols are based upon therapeutic strategies which include the use of administration of immunologically active mouse/human chimeric anti-CD20 antibodies, radiolabeled anti-CD20 antibodies, an ...


2
Robert T Foster: Method of using deuterated calcium channel blockers. Isotechnika, Smith Grambrell & Russell, April 24, 2001: US06221335 (171 worldwide citation)

Therapeutic methods and compositions using deuterated enriched 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester and other deuterated dihydropyridine compounds are described. The deuterated compounds exhibit enhanced effi ...


3
Patrick E Guire, Kristin S Taton, John V Wall: Particle immobilized coatings and uses thereof. Surmodics, Kagan Binder PLLC, March 25, 2014: US08679454 (163 worldwide citation)

Surface coatings including microparticles immobilized in a matrix of polymeric material on a substrate are described. The microparticles can also include an agent which can be useful for various applications, such as medical applications. This invention relates to the field of surface coatings for u ...


4
Fritzberg Alan R: Metal radionuclide labeled proteins for diagnosis and therapy.. Neorx, July 23, 1986: EP0188256-A2 (155 worldwide citation)

Protein conjugated chelated metal radionuclides are provided for use in vivo. Intermediates are provided for preparing the polypeptide compositions efficiently.


5
Rinat O Esenaliev: Radiation and nanoparticles for enhancement of drug delivery in solid tumors. Board of Regents The University of Texas System, Braman & Rogalskyj, December 26, 2000: US06165440 (144 worldwide citation)

The present invention discloses a method/system utilizing interaction of electromagnetic pulses or ultrasonic radiation with nano- and microparticles for enhancement of drug delivery in solid tumors. The particles can be attached to antibodies directed against antigens in tumor vasculature and selec ...


6
Gary L Griffiths, Hans J Hansen: Targeted combination immunotherapy of cancer. Immunomedics, Foley & Lardner, June 20, 2000: US06077499 (120 worldwide citation)

The invention provides compositions, methods and kits for effecting therapy of a tumor in a patient. The compositions comprise (A) a first conjugate comprising a targeting moiety, a first member of a binding pair, and a first therapeutic agent, wherein the targeting moiety selectively binds to a mar ...


7
Meyer Harry M Jr, Weiss Martin J: Suppression of b-cells in mammals.. American Cyanamid Co, September 20, 1989: EP0332865-A2 (106 worldwide citation)

Selective suppression of B-lymphocytes in mammals is accomplished by treatment with an adequate amount of antibody to a mature B-lymphocyte surface marker.


8
Candace McCombs, Joseph R Lakowicz, Omoefe Abugo, Zygmunt Gryczynski: Devices and methods for monitoring drug therapy compliance. Kilpatrick Stockton, December 16, 2003: US06663846 (105 worldwide citation)

Methods and compositions for the detection and monitoring of drug therapy are provided. In particular, efficient and sensitive methods for the detection of drug ingestion are provided for determining whether individuals are complying with prescribed therapeutic regimens, and for providing a mechanis ...


9
Roger Tung: Biphenyl-pyrazolecarboxamide compounds. Concert Pharmaceuticals, Edwards Angell Palmer & Dodge, Jeffrey D Hsi, Mark D Russett, April 7, 2009: US07514068 (102 worldwide citation)

The present invention relates to biphenyl-pyrazole compounds and in particular biphenyl-pyrazolecarboxamides. The invention further provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions beneficially treated by an ...


10
Darrell R Anderson, Nabil Hanna, John E Leonard, Roland A Newman, Mitchell E Reff, William H Rastetter: Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma. Burns Doane Swecker & Mathis, December 1, 1998: US05843439 (100 worldwide citation)

Disclosed herein are therapeutic treatment protocols designed for the treatment of B cell lymphoma. These protocols are based upon therapeutic strategies which include the use of administration of immunologically active mouse/human chimeric anti-CD20 antibodies, radiolabeled anti-CD20 antibodies, an ...