1
Donald G Wallace, Thomas L Smestad, John M McPherson, Karl A Piez, Saeid Seyedin, Rosa Armstrong: Methods of bone repair using collagen. Collagen Corporation, Ciotti & Murashige Irell & Manella, December 6, 1988: US04789663 (186 worldwide citation)

A method of repairing bone defects by use of suspensions containing purified atelopeptide, reconstituted, fibrillar skin collagen or bone collagen powder or mixtures thereof is disclosed. The suspensions provide matrices for conductive growth of bone into the defect. The skin collagen may also be ly ...


2
Makoto Kodama, Tsukasa Sakai, Keishiro Tsuda, Koichi Okita, Shigeru Asako, Masaharu Komamiya, Hiroshi Oinuma: Antithrombogenic materials. Agency of Industrial Science and Technology, Sumitomo Electric, Watanabe Pharmaceutical, Sughrue Mion Zinn Macpeak & Seas, July 2, 1991: US05028597 (176 worldwide citation)

An antithrombogenic material is described, comprising an expanded polytetrafluoroethylene base having a collagen layer provided on the surface thereof, and further provided thereon a composite layer of collagen and a mucopolysaccharide, and said collagen is crosslinked with a crosslinking agent.


3
Lloyd Wolfinbarger Jr: Composition for repair of defects in osseous tissues, method of making, and prosthesis. Bioscience Consultants, Klima & Hopkins, July 2, 1996: US05531791 (171 worldwide citation)

A biocompatible collagen/demineralized human bone composite material, method for making the same, and prostheses employing the same are disclosed, wherein the composite material may be formulated into a fluid injectable, gel or rehydratable freeze dried paste. The resultant products can be used eith ...


4
Teruo Miyata, Albert L Rubin, Kurt H Stenzel, Michael W Dunn: Collagen drug delivery device. Cornell Research Foundation, Edward J Mahler, August 14, 1979: US04164559 (171 worldwide citation)

Chemically-modified collagen membrane prepared at physiologic pH and soluble thereat provides a carrier for ophthalmic medication leaving no removable material after drug release.


5
Hoc M Nguyen, George H Chu: Mechanically sheared collagen implant material and method. Collagen Corporation, Ciotti & Murashige, February 10, 1987: US04642117 (168 worldwide citation)

An injectable collagen material composed of reconstituted, mechanically sheared atelopeptide collagen fibers. The material is prepared by passing reconstituted collagen fibers repeatedly through a rigid mesh screen, until a substantial reduction in fiber size and size-heterogeneity is achieved. The ...


6
Paul D Kemp, Robert M Carr Jr, John G Maresh: Collagen constructs. Organogenesis, David G Conlin, Linda M Buckley, October 26, 1993: US05256418 (155 worldwide citation)

The present invention provides collagen constructs and methods of making and using such constructs. The present invention also provides tissue equivalents having improved characteristics and methods of making and using such tissue equivalents. This invention also provides methods of producing highly ...


7
Thangavel Kuberasampath, Richard J Ridge: Bone collagen matrix for zenogenic implants. Creative Biomolecules, Lahive & Cockfield, December 4, 1990: US04975526 (133 worldwide citation)

Disclosed is a matrix material for implantation in a mammalian host comprising biocompatible mineral-free type I bone collagen, xenogenic to the host, and biodegradable therewithin. The matrix is manufactured from protein-extracted bone powder treated with certain swelling agents to increase its sur ...


8
Saeid Seyedin, Thomas Thomas, Hanne Bentz, Larry Ellingsworth, Rosa Armstrong: Polypeptide cartilage-inducing factors found in bone. Collagen Corporation, Ciotti & Murashige Irell & Manella, September 27, 1988: US04774322 (131 worldwide citation)

Two proteins that are found in bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-.beta. assay. Each has a molecular weight of approximately 26,000 daltons by SDS-PAGE. ...


9
George H Chu, Yasushi Ogawa, John M McPherson, George Ksander, Bruce Pratt, Diana Hendricks, Hugh McMullin: Collagen wound healing matrices and process for their production. Collagen Corporation, Irell & Manella, June 18, 1991: US05024841 (124 worldwide citation)

Collagen implants that are useful as wound healing matrices are characterized by being formed of collagen fibrils that are not chemically cross-linked, and having a bulk density of 0.01 to 0.3 g/cm.sup.3 and a pore population in which at least about 80% of the pores have an average pore size of 35 t ...


10
Crispin B Weinberg: Fibrin-collagen tissue equivalents and methods for preparation thereof. Organogenesis, David G Conlin, Linda M Buckley, June 6, 1989: US04837379 (110 worldwide citation)

The present invention provides fibrin-collagen tissue equivalents and methods of making and using such tissue equivalents. The present invention also provides methods of forming multi-layer tissue equivalents having improved adherence of the layers. The present invention further provides a method fo ...