1
Stéphane De Lombaert
Bakthavatchalam Rajagopal, Blum Charles A, Brielmann Harry, Chenard Bertrand L, de, Lombaert Stéphane, Hodgetts Kevin J, Hutchison Alan, Yoon Taeyoung, Zheng Xiaozhang: Biaryl piperazinyl-pyridine analogues. Neurogen Corporation, Bakthavatchalam Rajagopal, Blum Charles A, Brielmann Harry, Chenard Bertrand L, de, Lombaert Stéphane, Hodgetts Kevin J, Hutchison Alan, Yoon Taeyoung, Zheng Xiaozhang, ALEXANDER John B, January 27, 2005: WO/2005/007648 (17 worldwide citation)

Biaryl piperazinyl -pyri dine analogues are provided, of the Formula (I): wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with path ...


2
Toufike Kanouni
Qing Dong, Toufike Kanouni, John David Lawson, Michael B Wallace: Dihydropyrrolonaphtyridinone compounds as inhibitors of jak. Takeda Pharmaceutical Company, June 9, 2011: US20110136780-A1

Disclosed are JAK inhibitors of formula I where G1, R1, R2, R3, R4, R5, R6, and R7 are defined in the specification. Also disclosed are pharmaceutical compositions, kits and articles of manufacture which contain the compounds, methods and materials for making the compounds, and methods of using the ...


3
Kevin Rodzinak
Donna J Armstrong, Essa H Hu, Michael J Kelly III, Mark E Layton, Yiwei Li, Jun Liang, Kevin J Rodzinak, Michael A Rossi, Philip E Sanderson, Jiabing Wang: Inhibitors of akt activtiy. Merck, September 2, 2010: US20100222321-A1

The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt ...


4
Stéphane De Lombaert
Stéphane De Lombaert, Michel Jose Emmanuel: Chymase Inhibitors. Boehringer Ingelheim International, Michael P Morris, Boehringer Ingelheim Usa Corporation, February 4, 2010: US20100029637-A1

Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving chymase.


5
Stéphane De Lombaert
Rajagopal Bakthavatchalam, Timothy M Caldwell, Bertrand L Chenard, Stéphane De Lombaert, Kevin J Hodgetts: Substituted quinolin-4-ylamine analogues. Neurogen Corporation, Edward Angell Palmer & Dodge, November 19, 2009: US20090286767-A1

Substituted quinolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion ...


6
Sigal Irving S, Huff Joel R, Darke Paul L, Vacca Joseph P, Young Steven D, Desolms S Jane, Thompson Wayne J, Lyle Terry A, Graham Samuel L, Ghosh Arun K: Hiv protease inhibitors useful for the treatment of aids.. Merck & Co, October 18, 1989: EP0337714-A2 (242 worldwide citation)

Compounds of the form A-G-B-B-J wherein A is an amine protecting group commonly employed in peptide synthesis, G a dipeptide isostere, B an amino acid or analog thereof, and J a small terminal group are described. These compounds are useful in the inhibition of HIV protease, the prevention or treatm ...


7
Macpherson Lawrence J, Parker David Thomas: Arylsulfonamido-substituted hydroxamic acids.. Ciba-Geigy, July 13, 1994: EP0606046-A1 (214 worldwide citation)

Compounds of formula I wherein R, R1, R2 and Ar are as defined in the description, have valuable pharmaceutical properties and are effective especially as matrix metalloproteinase inhibitors, for example for the treatment of arthritis. They are prepared in a manner known per se.


8
Kato Hideo, Sakaguchi Jun, Aoyama Makoto, Izumi Tomoyuki, Kato Ken Ichi: 1h-imidazopyridine derivatives. Hokuriku Pharmaceutical, June 6, 2001: EP1104764-A1 (163 worldwide citation)

1H-Imidazopyridine derivatives represented by the following general formula or salts thereof: wherein R represents hydrogen atom, hydroxyl group, an alkyl group, a cycloalkyl group, styryl group, or an aryl group; R represents hydrogen atom, an alkyl group, a halogen atom, hydroxyl group, amino grou ...


9
Kempf Dale J, Plattner Jacob J, Norbeck Daniel W, Baker William R, Fung Anthony K L, Boyd Steven A, Erickson John W, Crowley Steven R: Retroviral protease inhibitors.. Abbott Lab, November 23, 1989: EP0342541-A2 (159 worldwide citation)

A retroviral protease inhibiting compound of the formula: or a pharmaceutically acceptable salt, prodrug or ester thereof.


10
Stephen L Crooks, George W Griesgraber, Philip D Heppner, Bryon A Merrill: Urea substituted imidazoquinoline ethers. 3M Innovative Properties Company, Dean A Ersfeld, December 9, 2003: US06660735 (154 worldwide citation)

Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and urea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety ...