31
Imamura Masakazu, Murakami Takeshi, Shiraki Ryota, Ikegai Kazuhiro, Sugane Takashi, Iwasaki Fumiyoshi, Kurosaki Eiji, Tomiyama Hiroshi, Noda Atsushi, Kitta Kayoko, Kobayashi Yoshinori: (Ja) c-グリコシド誘導体又はその塩, (En) C-glycoside derivatives and salts thereof. Astellas Pharma, Kotobuki Pharmaceutical, Imamura Masakazu, Murakami Takeshi, Shiraki Ryota, Ikegai Kazuhiro, Sugane Takashi, Iwasaki Fumiyoshi, Kurosaki Eiji, Tomiyama Hiroshi, Noda Atsushi, Kitta Kayoko, Kobayashi Yoshinori, WATANABE Kazuhira, September 23, 2004: WO/2004/080990 (54 worldwide citation)

(EN) A C-glycoside derivative represented by the following general formula (I) or its salt which is a compound useful as a Na+-glucose co-transportation inhibitor in a remedy for, e.g., diabetes, in particular, insulin-independent diabetes (type 2 diabetes) and insulin-dependent diabetes (type 1 dia ...


32
Yoshikuni Itoh, Kazuhiko Ohne, Hirokazu Tanaka: Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same.. Fujisawa Pharmaceutical Co, November 11, 1992: EP0512570-A1 (54 worldwide citation)

A compound of the formula : wherein R is aryl which may be substituted with halogen, nitro, amino, lower alkylamino, lower alkoxy or acylamino, R is hydrogen; alkyl; cycloalkyl; or lower alkyl which is substituted with cyclo(lower)alkyl, cyclo(lower)alkenyl, a heterocyclic group or aryl optionally s ...


33
Valiante Nicholas: Use of organic compounds for immunopotentiation. Chiron Corporation, Valiante Nicholas, COLLIER Steven W, October 14, 2004: WO/2004/087153 (52 worldwide citation)

The invention provides immunostimulatory compositions comprising a small molecule immuno-poteniator (SMIP) compound and methods of administration thereof. Also provided are methods of administering a SMIP compound in an effective amount to enhance the immune response of a subject to an antigen. Furt ...


34
Washburn William N, Girotra Ravindar N, Sher Philip M, Mikkilineni Amarendra B, Poss Kathleen M, Mathur Arvind, Gavai Ashvinikumar, Bisacchi Gregory S: Catecholamine surrogates useful as b3 agonists.. Squibb Bristol Myers Co, June 28, 1995: EP0659737-A2 (51 worldwide citation)

Compounds of the formula or pharmaceutically acceptable salts thereof wherein: A is a bond, -(CH2)n- or -CH(B)-, where n is an integer of 1 to 3 and B is -CN, -CON(R)R or -CO2R; R is lower alkyl, aryl or arylalkyl; R is hydrogen, hydroxy, alkoxy, -CH2OH, cyano, -C(O)OR , -CO2H, -CONH2, tetrazole, -C ...


35
Holton Robert A, Nadizadeh Hossain, Biediger Ronald J: Furyl and thienyl substituted taxanes as antitumour agents.. Univ Florida State, March 31, 1993: EP0534708-A1 (51 worldwide citation)

A taxane derivative of the formula wherein R is Z is -OT, T is hydrogen, hydroxyl protecting group, or -COT, T is H, C-C1/4 alkyl, C-C1/4 alkenyl, C-C1/4 alkynyl or monocylic aryl, R is benzoyl, substituted benzoyl or C-C1/4 alkoxycarbonyl, Ac is acetyl, and E and E are independently selected from h ...


36
Stunkel Walter, Wang Haishan, Yin Zheng: Biaryl linked hydroxamates: preparation and pharmaceutical applications. S Bio, Stunkel Walter, Wang Haishan, Yin Zheng, NAMAZIE Farah, May 6, 2005: WO/2005/040161 (49 worldwide citation)

The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to biaryl containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disor ...


37
Horwell David Christopher, Rees David C: 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics.. Warner Lambert Co, June 13, 1990: EP0372466-A2 (49 worldwide citation)

The invention concerns a series of novel 2-amino-monomethoxycyclohexyl amides of the general formula having analgesic and neuroprotective activity. The compounds bind selectively to the kappa opioid receptor. Pharmaceutical compositions containing the compounds, methods of using them, and processes ...


38
Tjoeng Foe Siong, Adams Steven Paul: Novel platelet-aggregation inhibitors.. Monsanto, January 24, 1990: EP0352249-A1 (48 worldwide citation)

Novel peptide mimetic compounds are provided which have useful activity as inhibitors of platelet aggregation. These compounds have the chemical structure wherein x = 6 to 10, y = 0 to 4, Z = H, COOH, CONH2 or Cl-6 alkyl, Ar = phenyl, biphenyl or napthyl, each substituted with 1 to 3 methoxy groups, ...


39
Johann Leban, Stefan Tasler: Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents. 4SC, Womble Carlyle Sandridge & Rice PLLC, Mark D Jenkins Esq, April 29, 2008: US07365094 (46 worldwide citation)

The present invention relates to compounds of the general formula (II) and salts and physiologically functional derivatives thereof, for the use as a medicament.


40
Jingrong Cao, Jeremy Green, Young Choon Moon, Jian Wang, Mark Ledeboer, Edmund Harrington, Huai Gao: Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases. Vertex Pharmaceuticals Incorporated, Karen K Brown, Vertex Pharmaceuticals Incorporated, August 1, 2006: US07084159 (45 worldwide citation)

The present invention provides compounds of formula I: or a pharmaceutically acceptable derivative o thereof, wherein A, B, Ra, R1, R2, R3, and R4 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase invol ...