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Brooks Dee W, Summers James B: Indole-, benzofuran-, and benzothiophene-containing lipoxygenase-inhibiting compounds.. Abbott Lab, March 13, 1991: EP0416609-A2 (69 worldwide citation)

Pro-drugs of potent 5-lipoxygenase inhibiting compounds comprise compounds of the formula in which A is an alkylene or alkenylene group, X is oxygen, sulfur, sulfoxyl, or substituted nitrogen, and Y is a group which includes substituted or unsubstituted carbocyclic or substituted or unsubstituted he ...


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Richard Eric Mewshaw, Stephen Todd Cohn: Aryl-carbaldehyde oxime derivatives and their use as estrogenic agents. Wyeth, Woodcock Washburn, January 2, 2007: US07157491 (65 worldwide citation)

This invention provides estrogen receptor modulators having the structure where R1–R5 are as defined in the specification; or a pharmaceutically acceptable salt thereof.


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Lang Hans Jochen Dr, Weichert Andreas Dr, Schwark Jan Robert Dr, Scholz Wolfgang Dr Unterortstr, Albus Udo Dr, Crause Peter Dr: Benzocondensed five membered heterocycles, process of their preparation, their use as drug, as diagnostic means and pharmaceuticals containing it.. Hoechst, February 22, 1995: EP0639573-A1 (64 worldwide citation)

There are described benzo-fused 5-membered ring heterocycles of the formula I where X is N or CR(6); Y is oxygen; A and B together are a bond or are both hydrogen if X is simultaneously CR(6) and Y is NR(7), one of these substituents R(1) to R(6) is a -CO-N = C(NH2)2 group; the other substituents R( ...


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Black Larry John, Bryant Henry Uhlman, Cullinan George Joseph, Kauffman Raymond Francis: Use of benzothiophenes for treatment of hypercholesterolaemia.. Lilly Co Eli, July 6, 1994: EP0605193-A1 (62 worldwide citation)

Use of a compound of formula (I): wherein n is 0, 1 or 2; R is hydroxyl, methoxy, C1-C7 alkanoyloxy, C3-C7 cycloalkanoyloxy, (C1-C6 alkoxy)-C1-C7 alkanoyloxy, substituted or unsubstituted aroyloxy, or substituted or unsubstituted aryloxycarbonyloxy; R is hydrogen, hydroxyl, chloro, bromo, methoxy, C ...


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Summers James B Jr, Gunn Bruce P, Brooks Dee W: Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds.. Abbott Lab, August 24, 1988: EP0279263-A2 (62 worldwide citation)

Compounds of the formula: wherein R1 is (1) hydrogen, (2) C1 to C4 alkyl, (3) C2 to C4 alkenyl, or (4) NR2R3, wherein R2 and R3 are independently selected from (1) hydrogen, (2) C1 to C4 alkyl and (3) hydroxyl, but R2 and R3 are not simultaneously hydroxyl; wherein X is oxygen, sulfur, SO2, or NR4, ...


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Rocher Jean Philippe, Bernardon Jean Michel: Imino-derivatives, process for their preparation and their use in human and veterinary medicine and in cosmetics.. Cird Galderma, November 19, 1992: EP0514269-A1 (58 worldwide citation)

Diaromatic compounds corresponding to the following general formula: in which: R1 is H, OH, -CH3, -CH2OH, -COR7, -CH(OH)CH3, -CH2OCOR8, and the like, R7 is H, OH, -OR10, N(r'r"), lower alkyl, and the like, R8 is linear or branched alkyl, or a sugar residue, R9 is OH, lower alkyl or N(r'r"), R10 bein ...


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Iyengar Rajesh R, Zhao Gang, Freeman Jennifer C, Gao Ju, Judd Andrew S, Kym Philip R, Lynch John K, Mulhern Mathew M, Souers Andrew J: Inhibitors of diacylglycerol o-acyltransferase type 1 enzyme. Abbott Laboratories, Iyengar Rajesh R, Zhao Gang, Freeman Jennifer C, Gao Ju, Judd Andrew S, Kym Philip R, Lynch John K, Mulhern Mathew M, Souers Andrew J, PARIAL Andrew M, November 29, 2007: WO/2007/137107 (56 worldwide citation)

The present invention relates to compounds of formula (I) wherein R1, R3, X, Q, Z, A, D, m, and n are defined herein. Pharmaceutical compositions and methods for treating DGAT-1 related diseases or conditions are also disclosed.


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Delaney Norma Gail: Aminobenzoic and aminocyclohexane-carboylic acid compounds, compositions, and their method of use.. Squibb & Sons, April 4, 1990: EP0361365-A1 (55 worldwide citation)

Compounds of the formula inhibit the action of neutral endopeptidase. As a result, such compounds produce diuresis, natriuresis, and lower blood pressure as well as being useful in the treatment of congestive heart failure, relieving pain, and diarrhea when administered to a mammalian host.