1
Macpherson Lawrence J, Parker David Thomas: Arylsulfonamido-substituted hydroxamic acids.. Ciba-Geigy, July 13, 1994: EP0606046-A1 (214 worldwide citation)

Compounds of formula I wherein R, R1, R2 and Ar are as defined in the description, have valuable pharmaceutical properties and are effective especially as matrix metalloproteinase inhibitors, for example for the treatment of arthritis. They are prepared in a manner known per se.


2
Bender Steven Lee, Broka Chris Allen, Campbell Jeffrey Allen, Castelhano Arlindo Lucas, Fisher Lawrence Emerson, Hendricks Robert Than, Sarma Keshab: Matrix metalloprotease inhibitors. Hoffmann La Roche, Agouron Pharma, June 25, 1997: EP0780386-A1 (167 worldwide citation)

Compounds of the formula: wherein: n is 0, 1 or 2; Y is hydroxy or XONH-, where X is hydrogen or lower alkyl; R is hydrogen or lower alkyl; R is hydrogen, lower alkyl, heteroalkyl, aryl, aralkyl, arylheteroalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heteroarylheteroalkyl, heterocy ...


3
Kempf Dale J, Plattner Jacob J, Norbeck Daniel W, Baker William R, Fung Anthony K L, Boyd Steven A, Erickson John W, Crowley Steven R: Retroviral protease inhibitors.. Abbott Lab, November 23, 1989: EP0342541-A2 (159 worldwide citation)

A retroviral protease inhibiting compound of the formula: or a pharmaceutically acceptable salt, prodrug or ester thereof.


4
Branca Quirico Dr, Maerki Hans Peter Dr, Neidhart Werner Dr, Ramuz Henri Prof Dr, Wostl Wolfgang Dr: Peptide derivatives of amino acids having a renin-inhibiting effect.. Hoffmann La Roche, October 3, 1990: EP0389898-A2 (139 worldwide citation)

The compounds of the formula in which A, R, R, R and R have the meaning stated in Claim 1, in the form of optically pure diastereomers, mixtures of diastereomers, diastereomeric racemates or mixtures of diastereomeric racemates, and pharmaceutically utilisable salts thereof, inhibit the action of th ...


5
Chandraratna Roshantha A S: Ethynylheteroaromatic acids having retinoic acid-like activity.. Allergan, June 29, 1988: EP0272921-A1 (114 worldwide citation)

Retinoid-like activity is exhibited by compounds of the formula wherein A is pyridyl, furyl, thienyl, pyridazinyl, pyrimidinyl or pyrazinyl; n is 0-5; and B is H, -COOH and its esters, amides and pharmaceutically acceptable salts, -CHO and its acetal derivatives, -COR1 and its ketal derivatives wher ...


6
Egbertson Melissa S, Hartman George D, Halczenko Wasyl, Laswell William L: Novel fibrinogen receptor antagonists.. Merck & Co, April 1, 1992: EP0478328-A1 (101 worldwide citation)

A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation.


7
Andrieux Jean, Houssin Raymond, Yous Said Laboratoire de Chimi, Guardiola Beatrice, Lesieur Daniel: Naphthalene derivatives, procedure for their preparation and pharmaceutical compositions containing them.. Adir, September 18, 1991: EP0447285-A1 (96 worldwide citation)

Composés de formule générale : dans laquelle R, R1 et R2 sont définis dans la description. Les composés de formule (1) sont utiles dans le traitement de désordres de système nerveux central.


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Banholzer Rolf Dr, Bauer Rudolf Dr, Reichl Richard Dr: Thienylcarboxylic acid ester of aminoalcohols, their quaternary products, their preparation and use of the compounds.. Boehringer Ingelheim Kg, Boehringer Ingelheim Int, March 27, 1991: EP0418716-A1 (95 worldwide citation)

The new compounds of formula (I) (where A, R1, Ra and R2 are defined in the description) can be manufactured by processes known per se and used as the active ingredients of drugs.


10
Alig Leo Dr, Edenhofer Albrecht Dr, Mueller Marcel Dr, Trzeciak Arnold, Weller Thomas Dr: Carboxylic-acid and sulphonic-acid amides.. Hoffmann La Roche, August 8, 1990: EP0381033-A1 (95 worldwide citation)

The novel carboxylic acid and sulphonic acid amides of the formula R-A-(W)a-X-(CH2)b-(Y)c-B-Z-COOR (I) in which R, A, W, X, Y, B, Z, R, a, b and c have the meaning given in the description, can be used in the treatment of thromboses, apoplexy, cardiac infarcts, inflammations, arteriosclerosis and tu ...