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Andreas G Weichert
Andreas Weichert, Joachim Brendel, Heinz Werner Kleemann, Hans Jochen Lang, Jan Robert Schwark, Udo Albus, Wolfgang Scholz: Ortho-substituted benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic agent, and a medicament comprising them. Hoechst Aktiengesellschaft, Finnegan Henderson Farabow Garrett & Dunner L, December 14, 1999: US06001881 (2 worldwide citation)

Benzoylguanidines of the formula I ##STR1## in which: R(1) to R(4) have the meanings given in the claims, are antiarrhythmic pharmaceuticals, having a cardioprotective component, which are also valuable for the prevention of ischemically induced damage, in particular in association with the triggeri ...


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Csaba √Čkes
Istvan Vago, Gyula Beke, Eva Bozo, Sandor Farkas, Katalin Hornok, Gyorgy Keseru, Eva Schmidt, Eva Szentirmay, Monika Vastag: Benzamide derivatives as bradykinin antagonists. Richter Gedeon Nyrt, Fish & Richardson P C, July 9, 2013: US08481527

The present invention relates to new phenylsulfamoyl benzamide derivatives of formula (I) wherein R1-R5 and Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selective antagonists of bradykinin B1, to processes for prod ...


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Macpherson Lawrence J, Parker David Thomas: Arylsulfonamido-substituted hydroxamic acids.. Ciba-Geigy, July 13, 1994: EP0606046-A1 (214 worldwide citation)

Compounds of formula I wherein R, R1, R2 and Ar are as defined in the description, have valuable pharmaceutical properties and are effective especially as matrix metalloproteinase inhibitors, for example for the treatment of arthritis. They are prepared in a manner known per se.


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Bender Steven Lee, Broka Chris Allen, Campbell Jeffrey Allen, Castelhano Arlindo Lucas, Fisher Lawrence Emerson, Hendricks Robert Than, Sarma Keshab: Matrix metalloprotease inhibitors. Hoffmann La Roche, Agouron Pharma, June 25, 1997: EP0780386-A1 (167 worldwide citation)

Compounds of the formula: wherein: n is 0, 1 or 2; Y is hydroxy or XONH-, where X is hydrogen or lower alkyl; R is hydrogen or lower alkyl; R is hydrogen, lower alkyl, heteroalkyl, aryl, aralkyl, arylheteroalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heteroarylheteroalkyl, heterocy ...


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Yves Ducharme, Jacques Y Gauthier, Petpiboon Prasit, Yves Leblanc, Zhaoyin Wang, Serge Leger, Michel Therien: Phenyl heterocycles as COX-2 inhibitors. Merck Frosst Canada, Curtis C Panzer, David L Rose, July 16, 1996: US05536752 (148 worldwide citation)

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.


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Solomon Rosenblatt: Polymeric broad-spectrum antimicrobial materials. Merocel Corporation, Ostrolenk Faber Gerb & Soffen, December 10, 1991: US05071648 (115 worldwide citation)

A sustained and controlled release form of iodine is achieved by a complex of polyvinyl alcohol and the iodine characterized by a low water solubility. The polyvinyl alcohol may be reacted to form hydroxylated polyvinyl acetal sponge and the sponge is topically applied as an antimicrobial agent whic ...


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William N Washburn, Ravindar N Girotra, Philip M Sher, Amarendra B Mikkilineni, Kathleen M Poss, Arvind Mathur, Gregory S Bisacchi, Ashvinikumar V Gavai: Catecholamine surrogates useful as .beta..sub.3 agonists. Bristol Myers Squibb Company, Burton Rodney, July 7, 1998: US05776983 (114 worldwide citation)

Compounds of the formula ##STR1## or pharmaceutically acceptable salts thereof wherein: A is a bond, --(CH.sub.2).sub.n -- or --CH(B)--, where n is an integer of 1 to 3 and B is --CN, --CON(R.sup.9)R.sup.9' or --CO.sub.2 R.sup.7 ;


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Luly Jay Richard, Kempf Dale John, Plattner Jacob John: Peptidylaminodiols.. Abbott Lab, July 22, 1987: EP0229667-A2 (111 worldwide citation)

A renin inhibiting compound of the formula: wherein A is a substituent; W is C=O or CHOH; U is CH2 or NR2, provided that when W is CHOH then U is CH2; R1 is loweralkyl, cycloalkylmethyl, benzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (4-imidazoyl)methyl, alpha , alpha - ...