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Bichon Daniel, Bussat Philippe, Schneider Michel: Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography.. Sint, November 27, 1991: EP0458745-A1 (292 worldwide citation)

Air or gas filled microballoons bounded by an interfacially deposited polymer membrane which can be dispersed in aqueous carrier liquids to be injected into living organisms or administered orally, rectally and urethrally for therapeutic or diagnostic purposes (echography). The properties of the pol ...


2
Zaffaroni Alejandro: Novel drug delivery device. Alza Corporation, Ciotti Thomas E, Sabatine Paul L, Mandell Edward L, November 25, 1975: US3921636 (292 worldwide citation)

A drug delivery device for administering drug at a controlled rate for a prolonged period of time is disclosed. The device comprises a plurality of reservoirs containing drug distributed through a matrix. The reservoirs and the matrix are formed of materials permeable to passage of drug. The rate of ...


3
Hunt C Anthony, Papahadjopoulos Demetrios T: Method of making uniformly sized liposomes and liposomes so made.. Univ California, September 30, 1981: EP0036676-A1 (243 worldwide citation)

A composition whereby pharmaceutically active ingredients such as the bis-anthracyclines disclosed and claimed in European Application Publication No. 0 004 467 may be effectively delivered to selected sites in a mammalian organism is made by incorporating the ingredients within uniformly sized lipo ...


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Widder Kenneth J, Westkaemper Peter J: Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production.. Molecular Biosystems, July 26, 1989: EP0324938-A1 (198 worldwide citation)

A microbubble-type ultrasonic imaging agent is provided comprising a parenterally-administerable aqueous medium containing a dispersion of microspheres predominantly of diameters less than 10 microns, wherein the microspheres consist of gas microbubbles encapsulated with water-insolubilized biocompa ...


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Moreau Jacques Pierre, Kitchell Judith P: Delivery system.. Biomeasure, February 1, 1989: EP0301856-A2 (180 worldwide citation)

A delivery system for agents, such as therapeutic agents, or other substances includes a biodegradable polymer and the agent or substance. The delivery system is coated with a barrier substance that decreases the quantity of the agent release from the system, compared to the quantity of the agent re ...


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Hauser Helmut Dr: Lipids in the aqueous phase.. Ciba-Geigy, September 7, 1983: EP0088046-A2 (168 worldwide citation)

Die vorliegende Erfindung betrifft ein neues, vorteilhaftes Verfahren zur Herstellung von unilamellaren Liposomen in wässriger Phase durch Ueberführen einer geeigneten Lipidkomponente, z.B. Phosphatidsäure, in die ionische Form, indem man die Lipiddispersion einer pH-Aenderung unterwirft und anschli ...


8
Kent John Scott, Sanders Lynda Mary, Lewis Danny Harvey, Tice Thomas Robert: Microencapsulation of water soluble polypeptides.. Syntex, May 26, 1982: EP0052510-A2 (168 worldwide citation)

This invention concerns novel sustained release microcapsule compositions comprising water-soluble, hormonally active polypeptides and optionally, a polymer hydrolysis modifying agent encapsulated in biocompatable, biodegradable polymers such as poly(lactide-co-glycolide) copoly


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Masao Kitajima 105 Ohaza Mizonuma Asaka shi, JP, Tsutomu Yamaguchi 169 1 Mifuku Ohhito cho, Saitama JP, Asaji Kondo 105 Ohaza Mizonuma Asaka shi, JP, Noriynki Muroya 1072 1 Yokkamachi, Tagata gun: Encapsulation method. Sughrue Rothwell Mion Zinn and Macpeak, September 12, 1972: US3691090 (165 worldwide citation)

A process for the preparation of capsules containing a core material, comprising dispersing the core material in a solution of an organic solvent and an encapsulating material, dispersing the dispersion in an aqueous inorganic salt solution and then removing the organic solvent, is disclosed.


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Oshlack Benjamin, Chasin Mark: Orally administrable opioid formulations having extended duration of effect.. Euro Celtique, April 12, 1995: EP0647448-A1 (161 worldwide citation)

Sustained release oral solid dosage forms of opioid analgesics are provided as multiparticulate systems which are bioavailable and which provide effective blood levels of the opioid analgesic for at least about 24 hours. A unit dose of the opioid analgesic contains a plurality of substrates includin ...