1
Steven L Regen: Synthetic phosphatidyl cholines useful in forming liposomes. Research Corporation, Scully Scott Murphy & Presser, November 27, 1984: US04485045 (385 worldwide citation)

Lower-.omega.-alkenoyloxy-long chain alkanoic anhydrides are synthesized from the .omega.-hydroxyalkanoic acids and are condensed with glycerophosphatidyl cholines to prepare alkenoyloxyalkanoic esters of glycerophosphatidyl cholines. These are used to make vesicles which are then polymerized in sit ...


2
John D Rodwell, Thomas J McKearn: Antibody conjugates for the delivery of compounds to target sites. Cytogen Corporation, Pennie & Edmonds, June 9, 1987: US04671958 (371 worldwide citation)

A method is described for the covalent attachment of linker groups to specific sites on antibody molecules directed against any desired target antigen (tumor, bacterial, fungal, viral, parasitic etc.). These linkers can be attached via amide or ester bonds to compounds for delivery which contain ava ...


3
Richard A Berg, Frederick H Silver, James M Pachence: Collagen matrix beads for soft tissue repair. MediMatrix, Michael Ebert, June 6, 1989: US04837285 (271 worldwide citation)

Collagen-based compositions for augmenting soft tissue, wound dressings, implants, injectable formulations or other drug delivery systems, comprising resorbable collagen matrix beads, the beads having an average pore size of from 50 to 350 microns, and the collagen comprising from 1 to 30% by volume ...


4
Frederick A Silver, Richard A Berg, David E Birk, Kevin Weadock, Conrad Whyne: Biodegradable matrix and methods for producing same. University of Medicine & Dentistry of New Jersey, Weiser & Stapler, October 27, 1987: US04703108 (254 worldwide citation)

There are disclosed processes for preparing biodegradable collagen-based matrices in sponge or sheet form wherein in one embodiment a collagen-based material including a collagen selected from the group consisting of types I, II and II collagens is freeze dried to form a collagen-based sponge which ...


5
Ioannis V Yannas, Philip L Gordon, Chor Huang, Frederick H Silver, John F Burke: Crosslinked collagen-mucopolysaccharide composite materials. Massachusetts Institute of Technology, Arthur A Smith Jr, David E Brook, July 28, 1981: US04280954 (196 worldwide citation)

Composite materials are disclosed which are formed by contacting collagen with a mucopolysaccharide and subsequently covalently crosslinking the resultant polymer. These composite materials have a balance of mechanical, chemical and physiological properties which make them useful in surgical sutures ...


6
Frederick H Silver, Richard A Berg, Charles J Doillon, Kevin Weadock, Conrad Whyne: Biodegradable matrix and methods for producing same. University of Medicine and Dentistry of New Jersey, Weiser & Stapler, November 13, 1990: US04970298 (190 worldwide citation)

This invention relates to a biodegradable collagen matrix having a pore size and morphology which enhances the healing of a wound. It further relates to a process for preparing the matrix. One embodiment of the invention comprises a biodegradable matrix which comprises collagen, hyaluronic acid and ...


7
Schneider Michel, Yan Feng, Grenier Pascal, Puginier Jerome, Barrau Marie Bernadette: Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof.. Sint, August 4, 1993: EP0554213-A1 (180 worldwide citation)

One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of ...


8
John W F Goers, Hurley D King, Chyi Lee, Daniel J Coughlin, Vernon L Alvarez, John D Rodwell, Thomas J McKearn: Antibody-therapeutic agent conjugates. Cytogen Corporation, Pennie & Edmonds, September 19, 1989: US04867973 (170 worldwide citation)

This invention relates to antibody-therapeutic agent conjugates having a therapeutic agent covalently attached to an antibody or antibody fragment. Also described are methods for intermediates in the preparation of antibody conjugates. Therapeutic in vivo methods utilizing such antibody-therapeutic ...


9
Michel Schneider, Bernard Lamy: Process for the dehydration of a colloidal dispersion of lipsomes. Battelle Memorial Institute, Finnegan Henderson Farabow Garrett & Dunner, October 21, 1980: US04229360 (163 worldwide citation)

The invention concerns a process for the dehydration of a colloidal dispersion of liposomes in an aqueous liquid medium, this process being aimed at extending the conservation of the liposomes and to enable their efficient use at a later date.


10
Marshall R Urist: Bone morphogenetic agents. The Regents of the University of California, Kenyon & Kenyon, January 3, 1989: US04795804 (117 worldwide citation)

The production and isolation of bone morphogenetic peptide agents displaying the osteoinductive and immunoreactive activity of bone morphogenetic protein (BMP) and deriving from natural, synthetic or recombinant DNA sources, and said agents.



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