1
Stephen P A Fodor, Lubert Stryer, J Leighton Read, Michael C Pirrung: Arrays of materials attached to a substrate. Affymetrix, Vern Norviel, Nancy J DeSantis, Joseph Liebeschuetz, April 28, 1998: US05744305 (870 worldwide citation)

A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reacto ...


2
Thomas M Brennan: Method and apparatus for conducting an array of chemical reactions on a support surface. ProtoGene Laboratories, Banner & Allegretti, December 12, 1995: US05474796 (678 worldwide citation)

The invention provides apparatus and methods for making arrays of functionalized binding sites on a support surface. The invention further provides apparatus and methods for sequencing oligonucleotides and for identifying the amino acid sequence of peptides that bind to biologically active macromole ...


3
Jonathan A Ellman: Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support. The Regents of the University of California, Townsend and Townsend Khourie and Crew, February 22, 1994: US05288514 (523 worldwide citation)

Methods, compositions, and devices for synthesis of therapeutically useful compounds. The invention provides a rapid approach for combinatorial synthesis and screening of libraries of derivatives of therapeutically important classes of compounds such as benzodiazepines, prostaglandins and .beta.-tur ...


4
Vincent L Vaillancourt: Treating hydrophobic filters to render them hydrophilic. Manresa, Ralph R Roberts, June 25, 1985: US04525374 (513 worldwide citation)

A method is described for coating a hydrophobic filter membrane so as to render said membrane hydrophilic. This method is particularly for treating polypropylene or polytetrafluoroethylene in which the filter membrane is contemplated to have a pore size not larger than two (2) microns. The treating ...


5
Richard B Kaplan: Open cell tantalum structures for cancellous bone implants and cell and tissue receptors. Ultramet, Charles H Schwartz, Ellsworth R Roston, February 1, 1994: US05282861 (468 worldwide citation)

A tantalum open cell structure is formed by chemical vapor deposition onto a reticulated carbon foam substrate. Tantalum has a long history of use as an implant material, in both bone and soft tissue. This lightweight, strong, porous structure, mimicking the microstructure of natural cancellous bone ...


6
Michael N Helmus, M Joshua Tolkoff, Carol L Raleigh: Medical device polymer. Harbor Medical Devices, Fish & Richardson, September 5, 1995: US05447724 (466 worldwide citation)

A medical device and a method for its manufacture. The function of the medical device requires exposure of the device to the tissue of a patient. The device has a tissue-exposed portion constructed to release an agent that inhibits adverse reaction to the presence of the device defined by a polymeri ...


7
Michael N Helmus, M Joshua Tolkoff, Carol L Raleigh: Medical device polymer. Harbor Medical Devices, Fish & Richardson P C, October 29, 1996: US05569463 (367 worldwide citation)

A medical device and a method for its manufacture. The function of the medical device requires exposure of the device to the tissue of a patient. The device has a tissue-exposed portion constructed to release an agent that inhibits adverse reaction to the presence of the device defined by a polymeri ...


8
You Ling Fan: Hydrophilic lubricious coatings. Union Carbide Chemicals & Plastics Technology Corporation, Paul W Leuzzi II, February 25, 1992: US05091205 (367 worldwide citation)

A new method is provided to impart a hydrophilic lubriciious coating onto articles such as medical devices. A device, for example a catheter, is first contacted with a polyisocyanate solution, to provide coupling, then contacted with a poly(carboxylic acid) solution to give a coating, and is then fi ...


9
Hilary Koprowski, Walter U Gerhard, Carlo M Croce: Method of producing antibodies. The Wistar Institute, April 1, 1980: US04196265 (333 worldwide citation)

Continuous cell lines of genetically stable fused cell hybrids capable of producing large amounts of monoclonal antibodies against specific viruses and their antigenic determinants have been developed. The cell lines are fused cell hybrids between viral antibody producing cells and myeloma cells. Fu ...


10
Patrick E Guire: Method of improving the biocompatibility of solid surfaces. Bio Metric Systems, James R Bauman Mary P Haller, Gregory P Kaihoi, November 27, 1990: US04973493 (316 worldwide citation)

A method for modifying the solid surface to improve its biocompatibility is disclosed. The method employs molecules of a biocompatible agent and a chemical linking moiety possessing a photochemically reactive group capable upon activation of covalently bonding to the solid surface and possessing a d ...