1
Zupancic Silvo, Skrabanja Vida: Process for preparation of o-desmethylvenlafaxine and its analogue. Krka D D Novo Mesto, December 26, 2007: EP1870395-A1 (38 worldwide citation)

The present invention belongs to the field of organic chemistry and refers to a process for the preparation of O -desmethylvenlafaxine (1-[2-Dimethylamino)-1-(4-hydroxyphenyl)ethyl]cyclohexanol) and its analogues. The invention also relates to a catalytic hydrogenation of cyano-group of the substitu ...


2
Zupancic Silvo: Process for preparing olmesartan medoxomil intermediate. KRKA TOVARNA ZDRAVIL DD NOVO MESTO, Hoffmann · Eitle, March 11, 2010: WO/2010/026255 (3 worldwide citation)

The present invention discloses a process for preparing tritylolmesartan medoxomil with purity greater than 98% and further converting such an intermediate to olmesartan medoxomil.


3
Zupancic Silvo, Pecavar Anica, Vrbinc Miha, Osolnik Renata: Process for the preparation of olmesartan medoxomil. Krka, Zupancic Silvo, Pecavar Anica, Vrbinc Miha, Osolnik Renata, STRAUSS Alexander, February 15, 2007: WO/2007/017135 (2 worldwide citation)

The present invention relates to an improved process for the manufacture of olmesartan and pharmaceutically acceptable salts and esters thereof as an active ingredient of a medicament for the treatment of hypertension and related diseases and conditions.


4
Zupancic Silvo, Pecavar Anica, Zupet Rok: A process for the synthesis of valsartan. Krka D D Novo Mesto, May 31, 2006: EP1661891-A1 (1 worldwide citation)

This invention relates to an improved process for preparing a valsartan, or a pharmaceutically acceptable salt thereof, or pharmaceutical preparation containing either entity wherein a compound of formula (II) or a salt thereof, is reacted with valine or an ester or a salt thereof in a solvent selec ...


5
Vrbinc Miha, Slanc Janika, Rangus Marija, Zupancic Silvo, Bevec Franci: Solid pharmaceutical composition comprising valsartan. Krka D D Novo Mesto, June 28, 2006: EP1674080-A1 (1 worldwide citation)

This invention relates to a solid pharmaceutical composition containing valsartan particles characterized in that the D 50 of said valsartan particles is 150 m or below and that the valsartan particles have a maximum diameter of no more than 1100 m, as determined by electron microscopy.


6
ZUPANCIC SILVO, VRECER FRANK, SKRABANJA VIDA, HVALEC MIRAN, SMRKOLJ MATEJ, GERMAN TAMARA: [fr] Préparation de sels de O-desméthylvenlafaxine, [de] Zubereitung von O-Desmethylvenlafaxin-Salzen, [en] Preparation of O-desmethylvenlafaxine salts. KRKA, November 18, 2009: EP2119695-A1 (1 worldwide citation)

[en] The present invention relates to a process for the preparation of a salt of O-desmethylvenlafaxine comprising a) dissolving or suspending O-desmethylvenlafaxine in the form of its base in a liquid medium selected from the group of solvents and suspending agents b) contacting O-desmethylvenlafax ...


7
ZUPANCIC SILVO, VRECER FRANK, SKRABANJA VIDA, HVALEC MIRAN, SMRKOLJ MATEJ, GERMAN TAMARA: [fr] Préparation de sels de O-desméthylvenlafaxine, [de] Zubereitung von O-Desmethylvenlafaxin-Salzen, [en] Preparation of O-desmethylvenlafaxine salts. KRKA, November 18, 2009: EP2119696-A1 (1 worldwide citation)

[en] The present invention relates to a process for the preparation of a salt of O-desmethylvenlafaxine comprising a) dissolving or suspending O-desmethylvenlafaxine in the form of its base in a liquid medium selected from the group of solvents and suspending agents b) contacting O-desmethylvenlafax ...


8
Vrbinc Miha, Jakse Renata, Bevec Franci, Zupancic Silvo: Solid pharmaceutical composition comprising irbesartan. Krka D D Novo Mesto, July 11, 2007: EP1806130-A1 (1 worldwide citation)

The present invention concerns preferably surfactant-free solid pharmaceutical formulations comprising, as an active ingredient, at least one of irbesartan and pharmaceutically acceptable salts thereof, and at least one disintegrant. Preferably, the active ingredient comprises irbesartan hydrochlori ...


9
Zupancic Silvo, Smrkolj Matej, Jakse Renata: Preparation of hydrochloride salts of tetrazole derivative. Krka Tovarna Zdravil Dd Novo Mesto, Zupancic Silvo, Smrkolj Matej, Jakse Renata, PATENTNA PISARNA DOO, February 2, 2006: WO/2006/011859 (1 worldwide citation)

The present invention relates to sesquihydrate hydrochloride salt of irbesartan and anhydrous hydrochloride salts of irbesartan. Irbesartan used as the starting material for the preparation of the described hydrochlorides of irbesartan can be in any form, e.g. it can be used when contained in a reac ...


10
Zupancic Silvo, Smrkolj Matej, German Tamara, Smodis Janez, Vrbinc Miha: Polymorphic forms of rosiglitazone base. Krka, Zupancic Silvo, Smrkolj Matej, German Tamara, Smodis Janez, Vrbinc Miha, BECKER KURIG STRAUS, February 14, 2008: WO/2008/017398 (1 worldwide citation)

The present invention relates to novel polymorphic forms of rosiglitazone base, as well as to a process for their preparation and pharmaceutical formulations containing it. The present polymorphic forms of rosiglitazone base are characterized by small average particle sizes and high solubility besto ...



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