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Damian O Arnaiz, Yuo Ling Chou, Brian D Griedel, Rushad E Karanjawala, Monica J Kochanny, Wheeseong Lee, Amy Mei Liang, Michael M Morrissey, Gary B Phillips, Karna Lyn Sacchi, Steven T Sakata, Kenneth J Shaw, R Michael Snider, Shung C Wu, Bin Ye, Zuchun Zhao: Ortho-anthranilamide derivatives as anti-coagulants. Berlex Laboratories, Carol J Roth, October 31, 2000: US06140351 (61 worldwide citation)

This invention is directed to compounds of formula (III): ##STR1## wherein B, C, D, E, R.sup.1, R.sup.2 and R.sup.3 are disclosed herein. These compounds are disclosed as being useful as anti-coagulants.


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Kenneth L Luskey, Jian Luo, Zuchun Zhao: Use of (−) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia. Metabolex, DiaTex, Townsend and Townsend and Crew, September 23, 2003: US06624194 (16 worldwide citation)

The present invention provides the use of (−) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives and compositions in the treatment of insulin resistance, Type 2 diabetes, hyperlipidemia and hyperuricemia. It further provides (−) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid deriva ...


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Xin Chen, Peng Cheng, L Edward Clemens, Jeffrey D Johnson, Jingyuan Ma, Alison Murphy, Imad Nashashibi, Christoper J Rabbat, Jiangao Song, Maria E Wilson, Yan Zhu, Zuchun Zhao: 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine. Metabolex, Gerald Suh, Swiss Tanner P C, December 29, 2009: US07638541 (12 worldwide citation)

Compounds, compositions, and methods relating to 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine or a pharmaceutically acceptable salt thereof are provided for the treatment of Type II diabetes and other diseases associated with poor glycemic control.


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Xin Chen, Peng Cheng, L Edward Clemens, Jeffrey D Johnson, Jingyuan Ma, Alison Murphy, Imad Nashashibi, Christopher J Rabbat, Jiangao Song, Maria E Wilson, Yan Zhu, Zuchun Zhao: 2,4-disubsituted thiazoles and pharmaceutical compositions thereof. Metabolex, Foley & Lardner, July 24, 2012: US08227495 (7 worldwide citation)

The present disclosure provides 2,4-disubstituted thiazoles of the general structure shown below that are agonists of G-protein coupled receptor (IC-GPCR2). Also, provided are compositions comprising these compounds as well as methods for using these compounds in a variety of applications including ...