1
Koya Keizo, Sun Lijun, Wu Yaming, Korbut Timoty, Zhou Dan, Du Zhenjian, Chen Shoujun, Tatsuta Noriaki, Liang Guiqing, Ono Mitsunori: Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer. Synta Pharmaceuticals, Koya Keizo, Sun Lijun, Wu Yaming, Korbut Timoty, Zhou Dan, Du Zhenjian, Chen Shoujun, Tatsuta Noriaki, Liang Guiqing, Ono Mitsunori, DAVIS Steven G, August 5, 2004: WO/2004/064826 (37 worldwide citation)

One embodiment of the present invention is a method of treating a subject with a multi-drug resistant cancer. The method comprises administering to the subject an effective amount of a compound represented by Structural Formula (I): Y is a covalent bond or a substituted or unsubstituted straight cha ...


2
Chae Junghyun, Demko Zachary, Ying Weiwen, Du Zhenjian, Foley Kevin, James David, Przewloka Teresa, Song Minghu, Zhang Shijie, Ng Howard P, Li Hao, Chimmanamada Dinesh U, Sun Lijun, Koya Keizo, Zhou Dan, Qin Shuzhen, Lee Chi Wan: Triazole compounds that modulate hsp90 activity. Synta Pharmaceuticals, Chae Junghyun, Demko Zachary, Ying Weiwen, Du Zhenjian, Foley Kevin, James David, Przewloka Teresa, Song Minghu, Zhang Shijie, Ng Howard P, Li Hao, Chimmanamada Dinesh U, Sun Lijun, Koya Keizo, Zhou Dan, Qin Shuzhen, Lee Chi Wan, DAVIS Steven G, December 6, 2007: WO/2007/139955 (14 worldwide citation)

The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, s ...


3
Zhou Dan, Qin Shuzen, Ying Weiwen: Method for treating inflammatory disorders. Synta Pharmaceuticals, Zhou Dan, Qin Shuzen, Ying Weiwen, DAVIS Steven G, May 15, 2008: WO/2008/057246 (13 worldwide citation)

The present invention relates to a method for suppressing the immune system in a subject in need thereof, and a method for treating an inflammatory or immune disorder in a subject in need thereof.


4
Lee Chi Wan, Przewloka Teresa, Ying Weiwen, Song Minghu, Du Zhenjian, Foley Kevin, Zhou Dan, Qin Shuzhen: Triazinone and diazinone derivatives useful as hsp90 inhibitors. Synta Pharmaceuticals, Lee Chi Wan, Przewloka Teresa, Ying Weiwen, Song Minghu, Du Zhenjian, Foley Kevin, Zhou Dan, Qin Shuzhen, DAVIS Steven G, October 2, 2008: WO/2008/118391 (13 worldwide citation)

The present invention relates to compounds according to formulae (IA) to (ID) and compositions that inhibit the activity of Hsp90. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disor ...


5
Ying Weiwen, Przewloka Teresa, Chae Junghyun, Zhang Shijie, Li Hao, Du Zhenjian, James David, Chimmanamada Dinesh U, Ng Howard P, Foley Kevin, Demko Zachary, Sun Lijun, Zhou Dan, Qin Shuzhen: Triazole compounds that modulate hsp90 activity. Synta Pharmaceuticals, Ying Weiwen, Przewloka Teresa, Chae Junghyun, Zhang Shijie, Li Hao, Du Zhenjian, James David, Chimmanamada Dinesh U, Ng Howard P, Foley Kevin, Demko Zachary, Sun Lijun, Zhou Dan, Qin Shuzhen, DAVIS Steven G, December 6, 2007: WO/2007/139967 (9 worldwide citation)

The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, s ...


6
Ono Mitsunori, Wada Yumiko, Brunkhorst Beatrice, Warchol Tadeusz, Wrona Wojciech, Zhou Dan, Vo Nha Huu: Inhibitors of il-12 production. Shionogi Biores, March 13, 2002: EP1185528-A1 (5 worldwide citation)

The invention relates to a compound of formula (I) which can inhibit the production of IL-12. Also disclosed is a method of inhibiting IL-12 production by administering to a patient in need thereof an effective amount of a compound of formula (I).


7
Ono Mitsunori, Sun Lijun, Przewloka Teresa, Zhang Shijie, Kostik Elena, Ying Weiwen, Wada Yumiko, Koya Keizo, Wu Yaming, Zhou Dan, Tatsuta Noriaki: Pyrimidine compounds. Synta Pharmaceuticals, September 22, 2004: EP1458687-A2 (5 worldwide citation)

This invention features pyrimidine compounds of formula (I): R1 is formula (II), aryl, or heteroaryl; each of R2 and R4, independently, is R, halogen, nitro, cyano, isothionitro, SR, or OR; or R2 and R4, taken together, is carbonyl; R3 is R, alkenyl, alkynyl, OR, OC(O)R, S02R, S(O)R, S(02)NRR, SR, N ...


8
Ono Mitsunori, Wada Yumiko, Sun Lijun, Chen Shoujun, Przewloka Teresa, Zhang Shijie, Borella Christopher, Koya Keizo, Foley Kevin, Xia Zhi Qiang, Li Hao, Zhou Dan: Dihydropyridine compounds for treating or preventing metabolic disorders. Synta Phamaceuticals, Ono Mitsunori, Wada Yumiko, Sun Lijun, Chen Shoujun, Przewloka Teresa, Zhang Shijie, Borella Christopher, Koya Keizo, Foley Kevin, Xia Zhi Qiang, Li Hao, Zhou Dan, INSOGNA Anthony M, March 24, 2005: WO/2005/025507 (3 worldwide citation)

This invention relates to dihydropyridine compounds of formula: (I) or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein A2, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, and m are defined herein, and compositions comprising such compounds. The invention als ...


9
Li Li, Chou Wu, Zhou Dan, Liu Feng: Apparatus and method for stateful web services enablement. Avaya Technology, LOWE Scott L, August 28, 2008: WO/2008/103934 (2 worldwide citation)

A web services enablement system includes a computer adapted to send and receive information to and from a first service, to send and receive information to and from a second service, which may not be a web service, to manage a connection with a third, stateful, service and to send and receive infor ...


10
Chimmanamada Dinesh U, Ying Weiwen, Przewloka Teresa, Zhang Shijie, Foley Kevin, Du Zhenjian, Zhou Dan, Qin Shuzhen: Triazole compounds that modulate hsp90 activity. Synta Pharmaceuticals, Chimmanamada Dinesh U, Ying Weiwen, Przewloka Teresa, Zhang Shijie, Foley Kevin, Du Zhenjian, Zhou Dan, Qin Shuzhen, DAVIS Steven G, December 6, 2007: WO/2007/139968 (1 worldwide citation)

The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, s ...