1
Ashutosh Chilkoti, Zhongping Yang, Jinho Hyun: Microstamping activated polymer surfaces. Duke University, Myers Bigel Sibley & Sajovec P A, January 16, 2007: US07163712 (49 worldwide citation)

Methods of attaching a ligand to a surface are described that include contacting a surface with a substrate containing an amphiphilic comb polymer. The substrate is configured to provide a pattern of the amphiphilic comb polymer on a selected region of the surface. The substrate can be separated fro ...


2
Ashutosh Chilkoti, Zhongping Yang: Microstamping activated polymer surfaces. Duke University, Myers Bigel Sibley & Sajovec, September 3, 2002: US06444254 (41 worldwide citation)

Functionalized polymer surfaces having reactive moieties thereon are contacted with stamps having ligands adsorbed thereto, the ligands also comprising reactive moieties. The reactive moieties of the functionalized surfaces and the ligands form covalent bonds, thus providing a method of microstampin ...


3
Zhongping Yang, Mark A Hjelle, Douglas S Hine: Method and apparatus for optimizing cardiac resynchronization therapy. Medtronic, Stephen W Bauer, August 3, 2010: US07769451 (31 worldwide citation)

In some embodiments, a method for optimizing cardiac resynchronization therapy (CRT) may include one or more of the following steps: (a) conducting a baseline measurement of a physical parameter of a patient before initiating CRT, (b) performing an implantation process including implanting a pacing ...


4
Zhongping Yang, Amy Elizabeth Thompson, Paulus G Adams, Koen Michels: Passive fixation medical electrical lead. Medtronic, Carol F Barry, November 26, 2013: US08594809 (7 worldwide citation)

An implantable passive fixation lead is disclosed. The passive fixation lead comprises an elongate lead body having at least one elongate conductive element. The lead body includes a proximal end and a distal end. A support member has a first surface and a second surface. The second surface is coupl ...


5
Zhongping Yang, Michael J Ebert, James M Anderson: Branched polyethylene oxide terminated biomedical polymers and their use in biomedical devices. Medtronic, Girma Wolde Michael, Michael C Soldner, November 1, 2005: US06961610 (5 worldwide citation)

A biomedical polymer has a substantially linear base polymer; and branched polyethylene oxide covalently bonded to the base polymer as surface active end groups. The branched polyethylene oxide has at least two, more particularly at least four, and still more particularly at least six branches. Suit ...


6
Ven Manda, Tommy D Bennett, Zhongping Yang: Implantable biosensor devices for monitoring cardiac marker molecules. Medtronic, Stephen W Bauer, December 15, 2009: US07632234 (4 worldwide citation)

An implantable biosensor system is disclosed for determining levels of cardiac markers in a patient to aid in the diagnosis, determination of the severity and management of cardiovascular diseases. The sensor includes nanowire sensor elements having a biological recognition element attached to a nan ...


7
Zhongping Yang, Eunjoo Jin, Laura Christoferson, Rajiv Shah: Antimicrobial coatings for medical devices and methods for making and using them. Medtronic MiniMed, Gates & Cooper, August 20, 2013: US08512731 (4 worldwide citation)

Embodiments of the invention provide methods for using compositions to inhibit microbial growth on a surface of a medical device having the composition applied thereto, to medical devices having the composition applied to a surface thereof and to methods for using the compositions to coat medical de ...


8
Rick D McVenes, Zhongping Yang: Implantable medical device having a conformal coating. Medtronic, September 21, 2010: US07801623 (2 worldwide citation)

A method for manufacturing an implantable electrical medical device includes forming a conductive substrate, placing the conductive substrate in a deposition chamber; and forming a conformal coating over the conductive substrate using atomic layer deposition. In various embodiments, the conformal co ...


9
Robert W Stadler, Zhongping Yang, Sarah A Audet, James K Carney, James D Reinke, Andrew J Ries, John D Wahlstrand: System and method for cardiac pacing. Medtronic, August 15, 2017: US09731138 (1 worldwide citation)

An implantable medical device system is configured to deliver cardiac pacing by receiving a cardiac electrical signal by sensing circuitry of a first device via a plurality of sensing electrodes, identifying by a control module of the first device a first cardiac event from the cardiac electrical si ...


10
James D Reinke, Sarah A Audet, Andrew J Ries, Robert W Stadler, John D Wahlstrand, Zhongping Yang: Ultrasound powered pulse delivery device. Medtronic, October 31, 2017: US09802055 (1 worldwide citation)

An implantable device system for delivering electrical stimulation pulses to a patient's body includes a pulse delivery device having a piezoelectric element that is enclosed by a housing and produces voltage signals delivered to the patient's body in response to receiving ultrasound energy. The pul ...