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Diane Harris Boschelli, Annette Marian Doherty, Ali Fattaey, David William Fry, Susanne Andrea Trumpp Kallmeyer, Zhipei Wu, Ellen Myra Dobrusin, Mark Robert Barvian: Pyrido[2,3-D]pyrimidines and 4-aminopyrimidines as inhibitors of cellular proliferation. Warner Lambert Company, Charles W Ashbrook, Rosanne Goodman, December 24, 2002: US06498163 (43 worldwide citation)

This invention provides pyridopyrimidines and 4-aminopyrimidines that are useful for treating cell proliferative disorders, such as cancer and restenosis. We have now discovered a group of 7,8-dihydro-2-(amino and thio)pyrido[2,3-d]pyrimidines and 2,4-diaminopyrimidines that are potent inh ...


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Mark Robert Barvian, William Alexander Denny, Ellen Myra Dobrusin, James Marino Hamby, Howard Daniel Hollis Showalter, Andrew Mark Thompson, Roy Thomas Winters, Zhipei Wu: Naphthyridinones for inhibiting protein tyrosine kinase and cell cycle kinase mediated cellular proliferation. Warner Lambert Company, Charles W Ashbrook, November 21, 2000: US06150359 (4 worldwide citation)

This invention relates to the inhibition of protein tyrosine kinase (PTK) and cell cycle kinase mediated cellular proliferation. More specifically, this invention relates to naphthyridinones and their use in inhibiting cellular proliferation and PTK or cell cycle kinase enzymatic activity.


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Zhipei Wu: Compound useful as a c-Met inhibitor. Eli Lilly and Company, Tina M Tucker, September 18, 2012: US08268836 (1 worldwide citation)

The present invention relates to a c-Met inhibitor or a pharmaceutically acceptable salt thereof useful in treating cancer mediated by activity of c-Met receptors.


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Ana Maria Castano Mansanet, Esteban Dominguez Manzanares, Ana Maria Escribano, Maria Carmen Fernandez, William Joseph Hornback, Alma Maria Jimenez Aguado, Eric George Tromiczak, Zhipei Wu, Hamideh Zarrinmayeh, Dennis Michael Zimmerman: Thiophene and furan compounds. Eli Lilly and Company, Tonya L Combs, January 5, 2010: US07642361

The present invention relates to thiophene and furan compounds and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive deficits associated with schizophrenia, Alzheimer's disease, dementia of the Alzheimer's type, mild cognitive impairment, ...


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Pamela Ann Albaugh, Esteban Dominguez Manzanares, Jian Eric Hong, William Joseph Hornback, Delu Jiang, Paul Leslie Ornstein, Michelle Lee Thompson, Eric George Tromiczak, Zhipei Wu, Hamideh Zarrinmayeh, Dennis Michael Zimmerman, Ana Maria Castano Mansanet, Larry Gene Huffman, William David Miller: Pyrrole and pyrazole derivatives as potentiators of glutamate receptors. Eli Lilly and Company, Tonya L Combs, December 1, 2009: US07625932

The present invention relates to pyrrole and pyrazole compounds of formula (I) and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive deficits associated with schizophrenia, Alzheimer's disease, dementia of the Alzheimer's type, mild cognit ...


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