1
Yves Ducharme, Jacques Y Gauthier, Petpiboon Prasit, Yves Leblanc, Zhaoyin Wang, Serge Leger, Michel Therien: Phenyl heterocycles as cox-2 inhibitors. Merck Frosst Canada, Curtis C Panzer, David L Rose, December 12, 1995: US05474995 (196 worldwide citation)

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases, ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.


2
Jacques Y Gauthier, Cheuk K Lau, Yves LeBlanc, Chun Sing Li, Patrick Roy, Michel Therien, Zhaoyin Wang: Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents. Merck Frosst Canada, Curtis C Panzer, David L Rose, September 3, 1996: US05552422 (167 worldwide citation)

The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encomp ...


3
Petpiboon Prasit, Daniel Guay, Zhaoyin Wang, Serge Leger, Michel Therien: Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2. Merck Frosst Canada, Curtis C Panzer, David L Rose, May 28, 1996: US05521213 (155 worldwide citation)

The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encomp ...


4
Yves Ducharme, Jacques Y Gauthier, Petpiboon Prasit, Yves Leblanc, Zhaoyin Wang, Serge Leger, Michel Therien: Phenyl heterocycles as cox-2 inhibitors. Merck Frosst Canada, Curtis C Panzer, David L Rose, August 27, 1996: US05550142 (151 worldwide citation)

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.


5
Yves Ducharme, Jacques Y Gauthier, Petpiboon Prasit, Yves Leblanc, Zhaoyin Wang, Serge Leger, Michel Therien: Phenyl heterocycles as COX-2 inhibitors. Merck Frosst Canada, Curtis C Panzer, David L Rose, July 16, 1996: US05536752 (148 worldwide citation)

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.


6
Daniel Dube, Richard Friesen, Rejean Fortin, Zhaoyin Wang, Jacques Yves Gauthier: Substituted pyridines as selective cyclooxygenase-2 inhibitors. Merck Frosst Canad, Richard C Billups, Curtis C Panzer, David L Rose, January 19, 1999: US05861419 (60 worldwide citation)

The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certa ...


7
Yves Ducharme, Jacques Yves Gauthier, Petpiboon Prasit, Yves Leblanc, Zhaoyin Wang, Serge Leger, Michel Therien: Phenyl heterocycles as COX-2 inhibitors. Merck Frosst Canada, Curtis C Panzer, David L Rose, January 20, 1998: US05710140 (36 worldwide citation)

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.


8
Cameron Black, Mario Girard, Daniel Guay, Zhaoyin Wang: Diphenyl stilbenes as prodrugs to COX-2 inhibitors. Merck Frosst Canada, Richard C Billups, David L Rose, March 31, 1998: US05733909 (34 worldwide citation)

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.


9
Yves Ducharme, Jacques Yves Gauthier, Petpiboon Prasit, Yves Leblanc, Zhaoyin Wang, Serge Leger, Michel Therien: Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases. Merck Frosst Canada, Curtis C Panzer, David L Rose, November 24, 1998: US05840746 (33 worldwide citation)

The present invention provides a method of treating a neurodegenerative disease and in particular Alzheimers disease which comprises administering to a human in need thereof a therapeutically effective amount of a non-steroid COX-II inhibitor. Although a wide range of COX-II inhibitors may be employ ...


10
Cameron Black, Serge Leger, Petpiboon Prasit, Zhaoyin Wang, Pierre Hamel, Yongxin Han, Gregory Hughes: 3,4-diaryl-2-hydroxy-2,5-dihydrofurans as prodrugs to COX-2 inhibitors. Merck Frosst Canada, Curtis C Panzer, David L Rose, December 16, 1997: US05698584 (30 worldwide citation)

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.