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Yves Ducharme, Jacques Y Gauthier, Petpiboon Prasit, Yves Leblanc, Zhaoyin Wang, Serge Leger, Michel Therien: Phenyl heterocycles as cox-2 inhibitors. Merck Frosst Canada, Curtis C Panzer, David L Rose, December 12, 1995: US05474995 (196 worldwide citation)

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases, ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.


2
Jacques Y Gauthier, Cheuk K Lau, Yves LeBlanc, Chun Sing Li, Patrick Roy, Michel Therien, Zhaoyin Wang: Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents. Merck Frosst Canada, Curtis C Panzer, David L Rose, September 3, 1996: US05552422 (167 worldwide citation)

The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encomp ...


3
Yves Ducharme, Jacques Y Gauthier, Petpiboon Prasit, Yves Leblanc, Zhaoyin Wang, Serge Leger, Michel Therien: Phenyl heterocycles as cox-2 inhibitors. Merck Frosst Canada, Curtis C Panzer, David L Rose, August 27, 1996: US05550142 (151 worldwide citation)

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.


4
Yves Ducharme, Jacques Y Gauthier, Petpiboon Prasit, Yves Leblanc, Zhaoyin Wang, Serge Leger, Michel Therien: Phenyl heterocycles as COX-2 inhibitors. Merck Frosst Canada, Curtis C Panzer, David L Rose, July 16, 1996: US05536752 (148 worldwide citation)

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.


5
Cheuk Kun Lau, Cameron Black, Daniel Guay, Jacques Yves Gauthier, Yves LeBlanc, Patrick Roy, Yves Ducharme, Pierre Hamel: N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors. Merck Frosst Canada, Curtis C Panzer, David L Rose, June 17, 1997: US05639780 (140 worldwide citation)

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.


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Cheuk K Lau, Cameron Black, Daniel Guay, Jacques Y Gauthier, Yves LeBlanc, Patrick Roy, Yves Ducharme, Pierre Hamel: N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors. Merck Frosst Canada, Curtis C Panzer, David L Rose, February 18, 1997: US05604253 (136 worldwide citation)

The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encomp ...


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Yves Ducharme, Jacques Yves Gauthier, Petpiboon Prasit, Yves Leblanc, Zhaoyin Wang, Serge Leger, Michel Therien: Phenyl heterocycles as COX-2 inhibitors. Merck Frosst Canada, Curtis C Panzer, David L Rose, January 20, 1998: US05710140 (36 worldwide citation)

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.


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Yves Ducharme, Jacques Yves Gauthier, Petpiboon Prasit, Yves Leblanc, Zhaoyin Wang, Serge Leger, Michel Therien: Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases. Merck Frosst Canada, Curtis C Panzer, David L Rose, November 24, 1998: US05840746 (33 worldwide citation)

The present invention provides a method of treating a neurodegenerative disease and in particular Alzheimers disease which comprises administering to a human in need thereof a therapeutically effective amount of a non-steroid COX-II inhibitor. Although a wide range of COX-II inhibitors may be employ ...


9
Michel Belley, Jacques Yves Gauthier, Erich Grimm, Yves LeBlanc, Chun Sing Li, Michel Therien, Cameron Black, Petpiboon Prasit, Cheuk Kun Lau, Patrick Roy: (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors. Merck Frosst Canada, Richard C Billups, David L Rose, February 1, 2000: US06020343 (25 worldwide citation)

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.


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