1
Barry L Karger, Frantisek Foret, Paul M Zavracky, E Nicol McGruer, Qifeng Xue, Yuriy M Dunayevskiy: Microscale fluid handling system. Northeastern University, Weingarten Schurgin Gagnebin & Hayes, February 16, 1999: US05872010 (323 worldwide citation)

A microscale fluid handling system that permits the efficient transfer of nanoliter to picoliter quantities of a fluid sample from the spatially concentrated environment of a microfabricated chip to "off-chip" analytical or collection devices for further off-chip sample manipulation and analysis is ...


2
Dallas E Hughes, Barry L Karger, James L Waters, Yuriy M Dunayevskiy: Method to detect and analyze tight-binding ligands in complex biological samples using capillary electrophoresis and mass spectrometry. Cetek Corporation, Weingarten Schurgin Gagnebin & Lebovici, August 13, 2002: US06432651 (63 worldwide citation)

This invention combines a capillary electrophoresis (CE) technique for screening complex biological samples with mass spectrometry (MS), to provide a streamlined procedure for identifying and characterizing candidate ligands in a complex biological sample that bind at a selected binding strength to ...


3
Yuriy M Dunayevskiy, James L Waters, Dallas E Hughes: Capillary electrophoretic methods to detect new biologically active compounds in complex biological material. Cetek Corporation, Weingarten Schurgin Gagnebin & Hayes, October 9, 2001: US06299747 (6 worldwide citation)

This invention relates to a competitive-binding, capillary electrophoretic method of detecting new therapeutic regulatory (modulating) and diagnostic compounds in natural samples and other complex biological materials. The present method generally comprises mixing a preselected, detectable target wi ...


4
Yuriy M Dunayevskiy, Dallas E Hughes: Capillary electrophoresis method for screening for affinity ligands using a detectable competitive ligand. Cetek Corporation, Weingarten Schurgin Gagnebin & Lebovici, January 4, 2005: US06837977 (5 worldwide citation)

The invention relates to a capillary electrophoresis-based method of screening complex materials for any unidentified affinity ligand that binds to a target of interest. The method subjects a plug of a mixture of the target and a complex material sample, and a separate plug of a known, tight-binding ...


5
Yuriy M Dunayevskiy, Dallas E Hughes, Andrew S Weiskopf: Size-exclusion-based extraction of affinity ligands and active compounds from natural samples. Cetek Corporation, Weingarten Schurgin Gagnebin & Lebovici, February 20, 2007: US07179592 (1 worldwide citation)

The invention encompasses an improved, rapid, size-exclusive method for screening for small molecular weight ligands that bind specifically to a protein target, using size-exclusion separation, ultrafiltration, and mass spectrometry.


6
Dallas E Hughes, James L Waters, Yuriy M Dunayevskiy: Capillary electrophoretic method to detect target-binding ligands and to determine their relative affinities. Cetek Corporation, Weingarten Schurgin Gagnebin & Lebovici, February 25, 2003: US06524866 (1 worldwide citation)

The invention relates to capillary electrophoretic methods for detecting ligands or hit compounds that can bind to a selected target at or above a selected binding strength. The method allows one to rank various ligands based on their relative affinity, i.e., the relative stability of the target/lig ...


7
Yuriy M Dunayevskiy, Dallas E Hughes, Andrew S Weiskopf: Size-exclusion-based extraction of affinity ligands and active compounds from natural samples. Weingarten Schurgin Gagnebin & Lebovici, May 2, 2002: US20020052006-A1 (1 worldwide citation)

The invention encompasses an improved, rapid, size-exclusive method for screening for small molecular weight ligands that bind specifically to a protein target, using size-exclusion separation, ultrafiltration, and mass spectrometry.