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Kyriacos C Nicolaou, Yun He, Sacha Ninkovic, Joaquin Pastor, Frank Roschangar, Francisco Sarabia, Hans Vallberg, Dionisios Vourloumis, Nicolas Winssinger, Zhen Yang, N Paul King, M Ray Finlay: Epothilone analogs. The Scripps Research Institute, Donald G Lewis, August 27, 2002: US06441186 (43 worldwide citation)

Epothilone A, epothilone B, analogs of epothilone and libraries of epothilone analogs are synthesized. Epothilone A and B are known anticancer agents that derive their anticancer activity by the prevention of mitosis through the induction and stabilization of microtubulin assembly. The analogs of ep ...


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Kyriacos C Nicolaou, N Paul King, M Ray Finlay, Yun He, Frank Roschangar, Dionisios Vourloumis, Hans Vallberg, Francisco Sarabia, Sacha Ninkovic, David Hepworth, Tianhu Li: Epothilone analogs. The Scripps Research Institute, Donald G Lewis, April 30, 2002: US06380394 (43 worldwide citation)

Novel analogs of epothilone A, epothilone B, and epothilone C are synthesized by Stille coupling thazole-stannanes to macrolactone intermediates. The synthetic epothilone analogs selectively prevent mitosis in cancer cells through the induction and stabilization of microtubulin assembly. Selected sy ...


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Nan Horng Lin, Yun He, Mark W Holladay, Keith Ryther, Yihong Li: 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission. Abbott Laboratories, Monte R Browder, May 13, 1997: US05629325 (35 worldwide citation)

Novel 3-pyridyloxymethyl heterocyclic ether compounds of the formula: ##STR1## or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission.


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Nan Horng Lin, Mark W Holladay, Melwyn A Abreo, David E Gunn, Suzanne A Lebold, Richard L Elliott, Yun He: Heterocyclic ether compounds useful in controlling neurotransmitter release. Abbott Laboratories, Jerry F Janssen, Monte R Browder, Michael J Ward, June 22, 1999: US05914328 (29 worldwide citation)

Novel heterocyclic ether compounds of the formula: ##STR1## wherein *, A,B, n, R.sup.1, R.sup.2 and X are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are useful in selectively activating or inhibiting neurotransmitter release; to therapeutically-effective ph ...


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David S Garvey, George M Carrera Jr, Stephen P Arneric, Youe Kong Shue, Nan Horng Lin, Yun He, Edmund L Lee, Suzanne A Lebold: Isoxazole, isothiazole and pyrazole compounds that enhance cognitive function. Abbott Laboratories, Richard A Elder, April 25, 1995: US05409946 (23 worldwide citation)

Novel isoxazole isothiazole and pyrazole compounds of the formula: ##STR1## wherein A, R.sup.1, and R.sup.2 are specifically defined, or pharmaceutical salts thereof, are selective and potent cholinergic ligands at neuronal nicotinic receptors, useful in the treatment of cognitive, neurological and ...


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Kyriacos C Nicolaou, Yun He, Sacha Ninkovic, Joaquin Pastor, Frank Roschangar, Francisco Sarabia, Hans Vallberg, Dionisios Vourloumis, Nicolas Winssinger, Zhen Yang, Nigel Paul King, M Ray Finlay: Epothilone analogs. The Scripps Research Institute, Donald G Lewis, December 9, 2003: US06660758 (20 worldwide citation)

Epothilone A, epothilone B, analogs of epothilone and libraries of epothilone analogs are synthesized. Epothilone A and B are known anticancers agents that derive their anticancer activity by the prevention of mitosis through the induction and stabilization of microtubule assembly. The analogs of ep ...


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Nan Horng Lin, Yun He, Mark W Holladay, Keith B Ryther, Yihong Li, Hao Bai: 3-Pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission. Abbott Laboratories, Lawrence S Pope, October 3, 2000: US06127386 (14 worldwide citation)

Novel 3-pyridyloxymethyl heterocyclic ether compounds of the formula: ##STR1## or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission. Key intermediates ...


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Li Chen, Yun He, Jason Christopher Wong: N-(2-amino-phenyl)-amide derivatives. Hoffman La Roche, George W Johnston, Patricia S Rocha Tramaloni, Gene J Yao, September 14, 2010: US07795315 (12 worldwide citation)

The present invention provides novel compounds of the general formula (I) and pharmaceutically acceptable salts thereof, processes for the manufacture of these novel compounds and medicaments containing such compounds. The compounds of the present invention show anti-proliferative and differentiatio ...