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Anthony J Martinez, Annapurna Pendri, Richard B Greenwald, Yun H Choe: Terminally-branched polymeric linkers and polymeric conjugates containing the same. Enzon, Roberts & Mercanti, November 28, 2000: US06153655 (77 worldwide citation)

The present invention is directed to polymeric- prodrug transport forms of the formula: ##STR1## wherein: B is a leaving group, OH, a residue of a hydroxyl-containing moiety or ##STR2## wherein B.sub.1 is a leaving group, OH or a residue of a hydroxyl-containing moiety;


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Richard B Greenwald, Annapurna Pendri, Yun H Choe: Acyl polymeric derivatives of aromatic hydroxyl-containing compounds. Enzon, Roberts & Mercanti L, January 4, 2000: US06011042 (72 worldwide citation)

The present invention is directed to conjugates such as polymeric prodrugs of aromatic, hydroxyl-containing compounds and methods of making and using the same. These polymeric prodrugs are preferably esters of hydroxyl-containing aromatic compounds and are formed by reacting a desired aromatic, hydr ...


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Richard B Greenwald, Annapurna Pendri, Yun H Choe: Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents. Enzon, Roberts & Mercanti, January 30, 2001: US06180095 (64 worldwide citation)

The present invention is directed to double prodrugs containing polymeric-based transport forms. These polymeric prodrugs are preferably of the formula:


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Richard B Greenwald, Yun H Choe, Annapurna Pendri: Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents. Enzon, Roberts & Mercanti L, October 16, 2001: US06303569 (61 worldwide citation)

The present invention is directed to double prodrugs containing polymeric-based transport forms. These polymeric compounds comprise the formula:


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Richard B Greenwald, Yun H Choe: Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents. Enzon, Robert & Mercanti, October 12, 1999: US05965119 (38 worldwide citation)

The present invention is directed to double prodrugs containing polymeric-based transport forms. These polymeric prodrugs are preferably of the formula: ##STR1## wherein: B is a leaving group or a residue of an amine-containing target moiety;


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Richard B Greenwald, Yun H Choe: Terminally-branched polymeric linkers containing extension moieties and polymeric conjugates containing the same. Enzon Pharmaceuticals, Muserlian Lucas & Mercanti, August 17, 2004: US06777387 (17 worldwide citation)

The present invention is directed to polymeric prodrug transport forms and methods of making and using the same. In one preferred aspect, the prodrugs are of the formula:


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Richard B Greenwald, Yun H Choe: Polymer conjugates of biologically active agents and extension moieties for facilitating conjugation of biologically active agents to polymeric terminal groups. Enzon, Muserlian Lucas & Mercanti, June 29, 2004: US06756037 (13 worldwide citation)

The present invention is directed to polymer conjugates of biologically active agents and methods of preparing the same. In preferred aspects of the invention, the conjugates are of the formula


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