1
Jan Lewandowski, Paul S Malchesky, Yukihiko Nose: Pulse voltammetry. The Cleveland Clinic Foundation, Fay Sharpe Beall Fagan Minnich & McKee, January 30, 1990: US04897162 (345 worldwide citation)

A glucose sensing apparatus and method includes an electrocatalytic sensor having a reference electrode and a sensing electrode. A periodic signal is comprised of a ramp voltage which is intermingled a series of square wave measurement pulses. This signal is applied to the sensor. Current levels are ...


2
Yukihiko Nose, Setsuo Takatani, Ichiro Sakuma: Motor driven sealless blood pump. Kyocera Corporation, Spensley Horn Jubas & Lubitz, March 21, 1995: US05399074 (117 worldwide citation)

A centrifugal blood pump, used for heart-lung machines or the like, comprises an impeller, a casing having a suction inlet and a delivery outlet and being equipped with a space for rotatably accommodating the impeller, and a magnetic drive means disposed outside the casing. The impeller is of a rota ...


3
Paul S Malchesky, Yukihiko Nose: Method and apparatus for on-line filtration removal of macromolecules from a physiological fluid. Japan Foundation for Artificial Organs, Baldwin Egan Walling & Fetzer, September 21, 1982: US04350156 (104 worldwide citation)

An on-line filtration system for the removal of macromolecules greater than 70,000 mol. wt. from a physiological solution, such as blood, in the therapeutic treatment of various disease states. For blood, the plasma (which contains the macromolecules) is separated continuously from the blood using a ...


4
Yukihiko Nose, Toshiyuki Shinohara, Ryo Kosaka, Hirohito Sumikura: Methods and apparatus for controlling a continuous flow rotary blood pump. Miwatec Incorporated, Baylor College of Medicine, Barry R Lipsitz, Douglas M McAllister, November 16, 2004: US06817836 (74 worldwide citation)

A control system for a continuous flow rotary blood pump is provided. A normal operating range of the blood pump is established. The normal operating range may comprise a normal pump flow range and a normal pressure head range. A target rotational speed of the pump is set in accordance with the norm ...


5
Tadashi Nakazawa, Yoshiyuki Takami, Kenzo Makinouchi, Yukihiko Nose: Blood pump having magnetic attraction. Kyocera Corporation, Baylor College of Medicine, Loeb & Loeb, November 19, 1996: US05575630 (72 worldwide citation)

A blood pump used for heart-lung machines comprising an impeller, a casing having a suction inlet and a delivery outlet and rotatably encasing the impeller, a magnetic driver disposed outside the casing, and a magnetic attraction force adjuster. The impeller has a rotationally symmetric shape, such ...


6
Yukihiko Nose, Koji Kayashima, Akinori Sueoka, Yoshihiro Asanuma, Shigeru Shinagawa, James Smith, Andrej Werynski, Paul S Malchesky: Method for treating blood plasma employing a hollow fiber membrane. Kuraray, Barry Kramer, September 6, 1983: US04402940 (60 worldwide citation)

This invention provides a method for treating blood plasma wherein a hollow fiber membrane which comprises at least a skin layer on one surface of the membrane and also a porous layer inside the membrane is employed. The skin layer of the membrane has micropores with average pore size of 50 to 450 A ...


7
Yukihiko Nose, Toshiyuki Shinohara, Ryo Kosaka, Hirohito Sumikura: Methods and apparatus for controlling a continuous flow rotary blood pump. Miwatec, Baylor College of Medicine, Lipsitz & McAllister, October 23, 2007: US07284956 (58 worldwide citation)

A control system for a continuous flow rotary blood pump is provided. A normal operating range of the blood pump is established. The normal operating range may comprise a normal pump flow range and a normal pressure head range. A target rotational speed of the pump is set in accordance with the norm ...


8
Yukihiko Nose, Paul S Malchesky: Method for low pressure filtration of plasma from blood. Takeda Chemical, Wenderoth Lind & Ponack, May 3, 1983: US04381775 (51 worldwide citation)

A method for carrying out separation of plasma from whole blood, in which whole blood is passed through a filtration membrane means of a material suitable for separating plasma from whole blood and having a pore size from 0.1 to 0.6 microns at positive pressure differential across the membrane in a ...


9
Yukihiko Nose: Multipurpose metabolic assist system. Takeda Chemical, Wenderoth Lind & Ponack, March 22, 1977: US04013564 (48 worldwide citation)

A multipurpose metabolic assist system has an inlet passageway, an outlet passageway, a treated blood component passageway spaced from the inlet passageway and extending to the outlet passageway. The system has at least one space between at least a portion of the inlet passageway and a portion of th ...


10
Yukihiko Nose, Setsuo Takatani, Ichiro Sakuma, Yasuhisa Ohara, Kenzo Makinouchi: Ceramic pivot bearing arrangement for a sealless blood pump. Kyocera Corporation, Baylor College of Medicine, Loeb & Loeb, February 3, 1998: US05713730 (48 worldwide citation)

A centrifugal blood pump, used for heart-lung machines or the like, having at least one impeller, a casing having an inlet and an outlet, the casing formed to have a space for rotatably housing the at least one impeller and a magnetic drive disposed outside the casing. The impeller may have vanes at ...