Keiji Iwasaki, Yuji Iwashita, Taketoshi Okami: Hemoglobin combined with a poly(alkylene oxide). Ajinomoto Co, Oblon Fisher Spivak McClelland & Maier, June 2, 1987: US04670417 (544 worldwide citation)

There is disclosed hemoglobin modified in that a poly(alkylene oxide) is bonded thereto by a bond between a terminal group of said poly(alkylene oxide) and an amino group of said hemoglobin, said bond having the structure:

Yuji Iwashita, Katsumi Ajisaka: Blood substitute containing modified hemoglobin. Ajinomoto Company Incorporated, Oblon Fisher Spivak McClelland & Maier, November 17, 1981: US04301144 (419 worldwide citation)

A novel modified hemoglobin was prepared. The hemoglobin is coupled with a polyalkylene glycol or its derivative, and the products are useful as a blood substitute. The oxygen-carrying capacity of this hemoglobin is nearly equal to that of a native hemoglobin, and the residence time in the circulati ...

Yuji Iwashita, Katsumi Ajisaka, Keiji Iwasaki: Oxygen carrier. Ajinomoto Company Incorporated, Oblon Fisher Spivak McClelland & Maier, November 1, 1983: US04412989 (214 worldwide citation)

An oxygen carrying material containing hemoglobin or a hemoglobin derivative covalently coupled through an amide bond to a polymer selected from the group consisting of polyethylene glycol, polypropylene glycol, and copolymers of ethylene oxide and propylene oxide.


Yuji Iwashita, Seiichi Endo, Keiichi Morimoto: Intermittent coating method and apparatus therefor. TDK Corporation, Lerner David Littenberg Krumholz & Mentlik, November 23, 1999: US05989622 (14 worldwide citation)

The method is related to intermittent coating capable of distinctly defining a boundary between a coated region and an uncoated region on a web, to thereby intermittently form a coated film on the web with increased accuracy and efficiency. A coating liquid feed pump is arranged so as to alternately ...

Akira Yabuki, Yuji Iwashita: Superoxide dismutase combined with a poly(alkylene oxide). Ajinomoto Co, Oblon Spivak McClelland Maier & Neustadt, November 19, 1991: US05066590 (2 worldwide citation)

Superoxide dismutase is chemically modified with poly(alkylene oxide), the modified superoxide dismutase having a molecular structure in which both ends of a poly(alkylene oxide) molecule are attached to superoxide dismutase. The modified superoxide dismutase can be used to remove toxic substances d ...