1
Yuhong Zhou, Roy C Levitt, Nicholas C Nicolaides, Steve Jones, Mike McLane: Mucin synthesis inhibitors. Genaera Corporation, Morgan Lewis & Bockius, March 18, 2008: US07345051 (6 worldwide citation)

The claimed invention relates to methods of modulating mucin synthesis and the therapeutic application of compounds of Formula II in controlling mucin over-production associated with diseases such as chronic obstructive pulmonary diseases (COPD) including asthma and chronic bronchitis, inflammatory ...


2
Yuhong Zhou, Brian Tomkowicz, Luigi Grasso, Nicholas C Nicolaides, Philip M Sass: Methods for inhibiting the binding of endosialin to ligands. Morphotek, Woodcock Washburn, October 5, 2010: US07807382 (4 worldwide citation)

The invention provides methods for inhibiting the interaction of endosialin with endosialin ligands. The inhibition is effectuated on the genetic level, by inhibiting endosialin gene expression, and on the protein level, by blocking the interaction of cell-surface expressed endosialin with ligands s ...


3
Yuhong Zhou, Roy C Levitt, Nicholas C Nicolaides, Steve Jones, Mike McLane: Mucin synthesis inhibitors. Genaera Corporation, Morgan Lewis & Bockius, May 18, 2004: US06737427 (3 worldwide citation)

The claimed invention relates to methods of modulating mucin synthesis and the therapeutic application of compounds in controlling mucin over-production associated with diseases such as chronic obstructive pulmonary diseases (COPD) including asthma and chronic bronchitis, inflammatory lung diseases, ...


4
Mark Bryers, Elango Ganesan, Frederick Gruner, David Hass, Robert Hathaway, Ramesh Panwar, Ricardo Ramirez, Abbas Rashid, Mark Vilas, Nazar Zaidi, Yen Lee, Chau Anh Ngoc Nguyen, John Phillips, Yuhong Zhou, Gregory G Spurrier, Sankar Ramanoorthi, Michael Freed: Content service aggregation system. Juniper Networks, Shumaker & Sieffert P A, July 14, 2015: US09083628 (2 worldwide citation)

A network content service apparatus includes a set of compute elements adapted to perform a set of network services; and a switching fabric coupling compute elements in said set of compute elements. The set of network services includes firewall protection, Network Address Translation, Internet Proto ...


5
Yuhong Zhou, Brian Tomkowicz, Luigi Grasso, Nicholas C Nicolaides, Philip M Sass: Methods for inhibiting the binding of endosialin to ligands. Morphotek, Baker & Hostetler, November 25, 2014: US08895000 (1 worldwide citation)

The invention provides methods for inhibiting the interaction of endosialin with endosialin ligands. The inhibition is effectuated on the genetic level, by inhibiting endosialin gene expression, and on the protein level, by blocking the interaction of cell-surface expressed endosialin with ligands s ...


6
Nicholas C Nicolaides, Philip M Sass, Luigi Grasso, Wolfgang Ebel, Yuhong Zhou: Polynucleotides encoding anti-GD2 antibodies. Morphotek, Woodcock Washburn, October 2, 2012: US08278065 (1 worldwide citation)

Described herein are antibodies that specifically bind ganglioside GD2. Also described are nucleotides encoding such antibodies, cells expressing such antibodies, methods of use for such antibodies, and methods for using the antibodies to treat diseases associated with ganglioside GD2. In addition, ...


7
Kenneth J Holroyd, Roy C Levitt, W Lee Maloy, Jamila Louahed, Mike McLane, Nicholas C Nicolaides, Yuhong Zhou, Qu Dong: Nucleic acids encoding a chloride channel protein. Genaera Corporation, Morgan Lewis & Bockius, April 6, 2004: US06716603 (1 worldwide citation)

A new gene in the calcium-activated chloride channel family has been discovered that is induced by IL-9, thereby providing a therapeutic target in IL-9 mediated development of atopic allergy, asthma-related disorders and cystic fibrosis. A method for the identification and use of small molecule inhi ...


8
Kenneth J Holroyd, Roy C Levitt, W Lee Maloy, Jamila Louahed, Mike McLane, Nicholas C Nicolaides, Yuhong Zhou, Qu Dong: Methods for identification of agents which modulate chloride channel activity. Genaera Corporation, Morgan Lewis & Bockius, June 10, 2003: US06576434 (1 worldwide citation)

A new gene in the calcium-activated chloride channel family has been discovered that is induced by L-9, thereby providing a therapeutic target in IL-9 mediated development of atopic allergy, asthma-related disorders and cystic fibrosis. A method for the identification and use of small molecule inhib ...


9
Yuhong Zhou, Brian Tomkowicz, Luigi Grasso, Nicholas C Nicolaides, Philip M Sass: Methods for inhibiting the binding of endosialin to ligands. Morphotek, Baker & Hostetler, November 29, 2016: US09505842

The invention provides methods for inhibiting the interaction of endosialin with endosialin ligands. The inhibition is effectuated on the genetic level, by inhibiting endosialin gene expression, and on the protein level, by blocking the interaction of cell-surface expressed endosialin with ligands s ...


10
Yuhong Zhou, Roy C Levitt, Nicholas C Nicolaides, Steve Jones, Mike McLane: Mucin synthesis inhibitors. Genaera Corporation, Morgan Lewis & Bockius, March 17, 2009: US07504409

The claimed invention relates to methods of modulating mucin synthesis and the therapeutic application of compounds in controlling mucin over-production associated with diseases such as chronic obstructive pulmonary diseases (COPD) including asthma and chronic bronchitis, inflammatory lung diseases, ...