1
David F Mark, Leo S Lin, Shi da Yu Lu, Alice M Wang: Cysteine-depleted muteins of biologically active proteins. Cetus Corporation, Albert P Halluin, Jane R McLaughlin, Kate H Murashige, September 25, 1990: US04959314 (229 worldwide citation)

Muteins of biologically active proteins such as IFN-.beta. and IL-2 in which cysteine residues that are not essential to biological activity have been deleted or replaced with other amino acids to eliminate sites for intermolecular crosslinking or incorrect intramolecular disulfide bridge formation. ...


2
David F Mark, Leo S Lin, Shi Da Yu Lu: Human recombinant cysteine depleted interferon-.beta. muteins. Cetus Corporation, Albert P Halluin, Leona L Lauder, Thomas E Ciotti, May 13, 1986: US04588585 (197 worldwide citation)

Muteins of biologically active proteins such as IFN-.beta. and IL-2 in which cysteine residues that are not essential to biological activity have been deleted or replaced with other amino acids to eliminate sites for intermolecular crosslinking or incorrect intramolecular disulfide bridge formation. ...


3
David F Mark, Leo S Lin, Shi Da Yu Lu: Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-.beta.. Cetus Corporation, Shyamala T Rajender, Albert P Halluin, April 12, 1988: US04737462 (115 worldwide citation)

A modified IFN-.beta. is provided wherein the cysteine residue at position 17 is deleted and serine is substituted therefor. DNA sequences coding for the modified protein, nucleotide primers used for the mutagenesis, appropriate cloning vectors, host organisms transformed with the vectors, methods f ...


4
Howard Chih Hao Wang, Su Yu Lu, Mu Chi Chiang, Carlos H Diaz: Formation of an indium retrograde profile via antimony ion implantation to improve NMOS short channel effect. Taiwan Semiconductor Manufacturing Company, George O Saile, Stephen B Ackerman, December 31, 2002: US06500739 (108 worldwide citation)

A method of forming a pocket implant region, to reduce short channel effects (SCE), for narrow channel length, NMOS devices, has been developed. After forming an indium pocket implant region, in the area of a P type semiconductor to be used to accommodate an N type source/drain region, an ion implan ...


5
Yu Lu, Randy Reagan, Craig M Standish: Hardened fiber optic connector compatible with hardened and non-hardened fiber optic adapters. ADC Telecommunications, Merchant & Gould P C, June 29, 2010: US07744288 (83 worldwide citation)

A fiber optic connector is disclosed for use with both a hardened fiber optic adapter and a non-hardened fiber optic adapter. The connector includes a connector housing having an end defining a plug portion. The plug portion includes first and second sets of retaining features for retaining the conn ...


6
David F Mark, Leo S Lin, Shi Da Yu Lu: Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of biologically active proteins. Cetus Corporation, Philip L McGarrigle, Albert P Halluin, Thomas E Ciotti, August 1, 1989: US04853332 (77 worldwide citation)

Muteins of biologically active proteins such as IFN-.beta. and IL-2 in which cysteine residues that are not essential to biological activity have been deleted or replaced with other amino acids to eliminate sites for intermolecular crosslinking or incorrect intramolecular disulfide bridge formation. ...


7
Jeff Gniadek, Tom Leblanc, Yu Lu, Keith Millea, Randy Reagan: Splitter modules for fiber distribution hubs. ADC Telecommunications, Merchant & Gould P C, July 17, 2007: US07245809 (74 worldwide citation)

A splitter module for a fiber distribution hub includes a main body with a first aperture configured to receive an input fiber entering the splitter module, and a second aperture configured for a plurality of distribution fibers exiting the splitter module. The splitter module also includes a fin co ...


8
Yu Lu, Randy Reagan: Hardened fiber optic connector. ADC Telecommunications, Merchant & Gould P C, August 11, 2009: US07572065 (67 worldwide citation)

The present disclosure relates to a fiber optic connector for use with a fiber optic adapter. The fiber optic connector includes a connector housing having an end defining a plug portion. A ferrule assembly is mounted at least partially within the connector housing. The ferrule assembly includes a f ...


9
Yu Lu, Randy Reagan, Craig M Standish: Hardened fiber optic connection system with multiple configurations. ADC Telecommunications, Merchant & Gould P C, June 29, 2010: US07744286 (65 worldwide citation)

A fiber optic connection system includes a ruggedized fiber optic adapter and a ruggedized fiber optic connector and can further include a standard fiber optic connector (e.g., an SC connector), a pre-existing ruggedized fiber optic adapter, a first converter for converting the standard fiber optic ...


10
Michael Noonan, Randy Reagan, Yu Lu, Jeff Gniadek: Fiber breakout with radio frequency identification device. ADC Telecommunications, Merchant & Gould P C, March 25, 2008: US07349605 (57 worldwide citation)

A fiber breakout for connecting a branch cable to a fiber optic distribution cable is disclosed. The fiber breakout can include an optical ribbon separated from the distribution cable at a breakout location. An overmold is formed over the optical ribbon and a portion of the distribution cable at the ...