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Younsik Cha, Young Kweon Choi, You Han Bae: Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers. Macromed, Thorpe North & Western L, December 30, 1997: US05702717 (194 worldwide citation)

A system and method for the parenteral delivery of a drug in a biodegradable polymeric matrix to a warm blooded animal as a liquid with the resultant formation of a gel depot for the controlled release of the drug. The system comprises an injectable biodegradable block copolymeric drug delivery liqu ...


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You Han Bae, Sang Yeob Park: PH-sensitive polymer containing sulfonamide and its synthesis method. Kwangju Institute of Science and Technology, Greer Burns & Crain, August 15, 2000: US06103865 (29 worldwide citation)

There are disclosed pH-sensitive polymers containing sulfonamide groups, which can be changed in physical properties, such as swellability and solubility, depending on pH and which can be applied for a drug-delivery system, bio-material, sensor, etc, and a preparation method therefor. The pH-sensiti ...


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You Han Bae, Kun Na, Seong Il Kang, Jin Woo Yi, Moon Hee Han: Liquefied embolic materials capable of sol-gel phase transition and their use. Kwangju Institute of Science and Technology, Rosenberg Klein & Lee, May 13, 2003: US06562362 (11 worldwide citation)

Disclosed are liquefied embolic materials capable of sol-gel phase transition in response to in vivo conditions, including temperature, ionic strength, and pH, and their uses. The liquefied embolic materials are made of copolymers based on temperature-sensitive isopropylacrylamide and ionic strength ...


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You Han Bae, Kun Na, Eun Seung Lee: pH-sensitive polymeric micelles for drug delivery. Clayton Howarth & Cannon P C, June 12, 2007: US07229973 (7 worldwide citation)

Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is aci ...


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You Han Bae, Kun Na, Eun Seong Lee: PH-sensitive polymeric micelles for drug delivery. University of Utah Research Foundation, Clayton Howarth & Cannon P C, February 9, 2010: US07659314 (3 worldwide citation)

Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is aci ...


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You Han Bae, Kun Na, Eun Seong Lee: Tumor environment-induced ligand-expressing nanocarrier system. University of Utah Research Foundation, Clayton Howarth & Cannon P C, May 13, 2008: US07371781 (2 worldwide citation)

Drug delivery compositions for specific delivery of a drug to a tumor are described. These compositions include a core for sequestering the drug and a shell to which a ligand is attached for delivery of a drug to target cells. Since normal cells may also be targeted by the ligand, the compositions e ...


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You Han Bae, Kun Na, Eun Seong Lee: pH-sensitive polymeric micelles for drug delivery. Clayton Howarth & Cannon P C, May 31, 2011: US07951846 (1 worldwide citation)

Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is aci ...


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Darrell R Fisher, You Han Bae, Zhonggao Gao: Brachytherapy seed with fast dissolving matrix for optimal delivery of radionuclides to cancer tissue. Battelle Memorial Institute, University of Utah Research Foundation, Wells St John P S, March 22, 2016: US09289625

A system, method and device for treating tumor cells utilizing a resorbable therapy seed made up of microspheres containing a beta- or alpha-particle-emitting radiation source and a resorbable polymer matrix. These seeds are implanted within the tumor and then rapidly dissolved so as to release the ...



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