1
Yoshiro Niitsu, Junji Kato, Yasushi Sato: Drug carrier and drug carrier kit for inhibiting fibrosis. Nitto Denko Corporation, Knobbe Martens Olson & Bear, May 8, 2012: US08173170 (15 worldwide citation)

An astrocyte-specific drug carrier containing a retinoid derivative and/or a vitamin A analog as a constituent; a drug delivery method with the use of the same; a drug containing the same; and a therapeutic method with the use of the drug. By binding a drug carrier to a retinoid derivative such as v ...


2
Yoshiro Niitsu, Junji Kato, Yasushi Sato: Drug carrier and drug carrier kit for inhibiting fibrosis. Nitto Denko Corporation, Knobbe Martens Olson & Bear, May 15, 2012: US08178124 (13 worldwide citation)

An astrocyte-specific drug carrier containing a retinoid derivative and/or a vitamin A analog as a constituent; a drug delivery method with the use of the same; a drug containing the same; and a therapeutic method with the use of the drug. By binding a drug carrier to a retinoid derivative such as v ...


3
Yoshiro Niitsu, Victor Knopov, Joseph E Payne, Richard P Witte, Mohammad Ahmadian, Loren A Perelman, Violetta Akopian, Yasunobu Tanaka, Elena Feinstein, Sharon Avkin Nahum, Hagar Kalinski, Igor Mett, Kenjiro Minomi, Wenbin Ying, Yun Liu: Retinoid-liposomes for treating fibrosis. Nitto Denko Corporation, Baker & Hostetler, June 3, 2014: US08741867 (7 worldwide citation)

What is described are pharmaceutical compositions comprising a double-stranded nucleic acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1_2 (SEQ ID NOS: 60 and 127), SERPINH1_45a (SEQ ID ...


4
Yoshiro Niitsu, Junji Kato, Masato Higuchi: Pharmaceutical composition for treatment of hepatic diseases. Chugai Seiyaku Kabushiki Kaisha, Finnegan Henderson Farabow Garrett & Dunner L, July 31, 2001: US06268336 (7 worldwide citation)

The present invention relates to a pharmaceutical composition for treatment of hepatic diseases which comprises erythropoietin as an active ingredient to reduce excess iron ions in the liver of a mammal with hepatic diseases, thus improving hepatic functions of said mammal. According to the present ...


5
Yoshiro Niitsu, Lei Yu, Jian Liu, Gang Zhao, Nianchun Ma, Sang Van: Drug carriers. Nitto Denko Corporation, Knobbe Martens Olson & Bear, August 23, 2011: US08003621 (6 worldwide citation)

Compositions that can include a cationic polymeric carrier, targeting agent, and therapeutic agent are disclosed herein. The therapeutic agent may have a therapeutic activity such as inhibiting fibrosis within a target organ or tissue or inhibiting the growth of a cancer cell.


6
Yoshiro Niitsu, Victor Knopov, Joseph E Payne, Richard P Witte, Mohammad Ahmadian, Loren A Perelman, Violetta Akopian, Yasunobu Tanaka, Elena Feinstein, Sharon Avkin Nahum, Hagar Kalinski, Igor Mett, Kenjiro Minomi, Wenbin Ying, Yun Liu: Retinoid-liposomes for enhancing modulation of HSP47 expression. Nitto Denko Corporation, Baker & Hostetler, March 4, 2014: US08664376 (6 worldwide citation)

What is described are pharmaceutical compositions comprising a double-stranded nucleic acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1—2 (SEQ ID NOS: 60 and 127), SERPINH1—45a (SEQ ID ...


7
Yoshiro Niitsu, Rishu Takimoto: Targeting agent for cancer cell or cancer-associated fibroblast. Nitto Denko Corporation, Knobbe Martens Olson & Bear, April 1, 2014: US08686052 (5 worldwide citation)

Disclosed are a novel therapeutic agent and a novel treatment method for cancer. Specifically disclosed are: a targeting agent for a cell selected from the group consisting of a cancer cell and a cancer-associated fibroblast, which comprises a retinoid; a substance delivery carrier for the cell, whi ...


8
Yoshiro Niitsu, Victor Knopov, Joseph E Payne, Zheng Hou, John A Gaudette, Violetta Akopian, Richard P Witte, Mohammad Ahmadian, Loren A Perelman, Yasunobu Tanaka, Priya Karmali, Sridhar C Nagarajan: Cationic lipids for therapeutic agent delivery formulations. Nitto Denko Corporation, Baker & Hostetler, April 21, 2015: US09011903 (5 worldwide citation)

Here described are compounds of formula I: wherein R1 and R2 is independently selected from a group consisting of C10 to C18 alkyl, C12 to C18 alkenyl, and oleyl group; wherein R3 and R4 are independently selected from a group consisting of C1 to C6 alkyl, and C2 to C6 alkanol; wherein X is selected ...


9
Yoshiro Niitsu, Rishu Takimoto, Kenjiro Minomi, Miyono Miyazaki, Keiko Kajiwara, Yasunobu Tanaka: Therapeutic agent for pulmonary fibrosis. Nitto Denko Corporation, Knobbe Martens Olson & Bear, November 5, 2013: US08574623 (4 worldwide citation)

Disclosed are: a substance transfer carrier to an extracellular matrix-producing cell in the lung, which comprises a retinoid; a therapeutic agent for pulmonary fibrosis, which utilized the carrier; and a preparation kit of the therapeutic agent.


10
Yoshiro Niitsu, Junji Kato, Yasushi Sato: Drug carrier and drug carrier kit for inhibiting fibrosis. Nitto Denko Corporation, Knobbe Martens Olson & Bear, February 18, 2014: US08652526 (4 worldwide citation)

An astrocyte-specific drug carrier containing a retinoid derivative and/or a vitamin A analog as a constituent; a drug delivery method with the use of the same; a drug containing the same; and a therapeutic method with the use of the drug. By binding a drug carrier to a retinoid derivative such as v ...