1
Yoshikawa Seiji, Emori Eita, Matsuura Fumiyoshi, Clark Richard, Ikuta Hironori, Yasuda Nobuyuki, Nagakura Tadashi, Yamazaki Kazuto, Aoki Mika: Xanthine derivatives as dpp-iv inhibitors. Eisai, August 27, 2003: EP1338595-A2 (68 worldwide citation)

The present invention provides novel compounds exhibiting an excellent DPPIV inhibition effect. The compounds are represented by the formula: wherein, m is 0 or 1; n is 0; R, R, R, R, R, R, R, R, R, R, R, and R each represent a hydrogen atom; X represents an alkynyl group, an aryl group, and such, w ...


2
Asano Osamu, Harada Hitoshi, Hoshino Yorihisa, Yoshikawa Seiji, Inoue Takashi, Horizoe Tatsuo, Yasuda Nobuyuki, Nagata Kaya, Nagaoka Junsaku, Murakami Manabu, Kobayashi Seiichi: Purine derivatives and adenosine a2 receptor antagonists serving as preventives/remedies for diabetes. Eisai, November 22, 2000: EP1054012-A1 (63 worldwide citation)

The present invention provides a preventive or therapeutic agent of a new type for diabetes mellitus and diabetic complications on the basis of an adenosine A2 receptor antagonistic action. A purine compound represented by the formula (I), its pharmacologically acceptable salt or hydrates thereof ha ...


3
Yoshikawa Seiji, Emori Eita, Matsuura Fumiyoshi, Richard Clark, Ikuta Hironori, Kira Kazunobu, Yasuda Nobuyuki, Nagakura Tadashi, Yamazaki Kazuto: Novel fused imidazole derivative. Eisai, March 16, 2005: EP1514552-A1 (57 worldwide citation)

The present invention is related to compounds represented by the following formula, or salts or hydrates thereof wherein, T represents a 4- to 12-membered heterocyclic group containing one or two nitrogen atoms in the ring, which is a monocyclic or bicyclic structure that may have one or more substi ...


4
Asano Osamu, Harada Hitoshi, Yoshikawa Seiji, Watanabe Nobuhisa, Inoue Takashi, Horizoe Tatsuo, Yasuda Nobuyuki, Ohashi Kaya, Minami Hiroe, Nagaoka Junsaku, Murakami Manabu, Kobayashi Seiichi, Tanaka Isao, Kawata Tsutomu, Shimomura Naoyuki, Akamatsu Hiroshi, Ozeki Naoki, Shimizu Toshikazu, Hayashi Kenji, Haga Toyokazu: Fused imidazole compounds and remedies for diabetes mellitus. Eisai, July 10, 2002: EP1221444-A1 (32 worldwide citation)

The present invention provides a preventive or therapeutic agent for diabetes mellitus and diabetic complications, which is a new type based on an adenosine A2 receptor antagonist action. That is, it provides a novel condensed imidazole compound which has an adenosine A2 receptor antagonist action, ...


5
Kira Kazunobu, Clark Richard, Yoshikawa Seiji, Uehara Taisuke: (Ja) 1,3−ジヒドロ−イミダゾール縮合環化合物, (En) 1,3-dihydroimidazole fused-ring compound. Eisai, Kira Kazunobu, Clark Richard, Yoshikawa Seiji, Uehara Taisuke, SHIMIZU Hatsushi, June 17, 2004: WO/2004/050656 (28 worldwide citation)

(EN) A novel compound having excellent DPPIV inhibitory activity. It is a compound represented by the general formula (I) (wherein T1 means an optionally substituted, mono- or bicyclic, 4- to 12-membered heterocycle containing one or two nitrogen atoms therein; the structure shown by (II) means a do ...


6
Yoshikawa Seiji, Hayashi Yusuke: (Ja) 撮像装置および撮像方法, (En) Imaging device and imaging method. Kyocera Corporation, Yoshikawa Seiji, Hayashi Yusuke, SATOH Takahisa, March 2, 2006: WO/2006/022373 (15 worldwide citation)

(EN) There are provided an imaging device and an imaging method capable of designing a lens without considering the object distance or defocus range and image restoration with a highly accurate calculation. The imaging device includes: an imaging lens device (200) for imaging an object dispersion im ...


7
Asano Osamu, Harada Hitoshi, Hoshino Yorihisa, Yoshikawa Seiji, Inoue Takashi, Horizoe Tatsuo, Yasuda Nobuyuki, Nagata Kaya, Nagaoka Junsaku, Murakami Manabu, Kobayashi Seiichi, Ohashi Kaya: Purine compounds and adenosine a2 receptor antagonist as preventive or therapeutic agent for diabetes mellitus. Eisai, April 9, 2003: EP1300147-A1 (12 worldwide citation)

The present invention relates to the use of A2 receptor antagonists and their pharmacologically acceptable salts or hydrates for preparing medicaments for preventing or treating diabetes mellitus or diabetic complications, and for preparing improving agents for impaired glucose tolerance, potentiati ...


8
Shimomura Naoyuki, Sato Nobuaki, Kaneko Toshihiko, Takaishi Mamoru, Wakasugi Kazunori, Yoshikawa Seiji, Nishikawa Yoshihiro, Nakamura Taiju, Hukuyama Tohoru: (Ja) シンナミド誘導体の製造方法, (En) Process for production of cinnamamide derivative. Eisai R & D Management, Shimomura Naoyuki, Sato Nobuaki, Kaneko Toshihiko, Takaishi Mamoru, Wakasugi Kazunori, Yoshikawa Seiji, Nishikawa Yoshihiro, Nakamura Taiju, Hukuyama Tohoru, ASAMURA Kiyoshi, May 24, 2007: WO/2007/058305 (10 worldwide citation)

(EN) A compound (8) represented by the formula: (8) [wherein R1 represents a 6- to 14-membered aromatic hydrocarbon ring group which may have a substituent; and n represents 0 to 2] can be produced with good efficiency by reacting a compound (1) represented by the formula: (3) [wherein R1 and n are ...


9
Nomichi Shinji, Satake Toru, Sofugawa Takuji, Kaneuma Toshifumi, Hatakeyama Masaki, Yoshikawa Seiji, Murakami Takeshi, Watanabe Kenji, Karimata Tsutomu, Suematsu Kenichi, Tanabe Yutaka, Tajima Ryo, Toyama Keiichi: Inspection apparatus by charged particle beam and method for manufacturing device using inspection apparatus. Ebara, December 24, 2004: JP2004-363085 (9 worldwide citation)

PROBLEM TO BE SOLVED: To provide a system for further increasing an inspection speed of an inspection apparatus in an SEM system, namely for increasing throughput.SOLUTION: The inspection apparatus for inspecting the surface of a substrate creates a crossover from electrons generated from an electro ...


10
Yasuda Nobuyuki, Nagakura Tadashi, Yamazaki Kazuto, Yoshikawa Seiji, Okada Toshimi, Ikuta Hironori, Koyanagi Mika: Pharmaceutical use of n-carbamoylazole derivatives. Eisai, November 20, 2002: EP1258480-A1 (8 worldwide citation)

The present invention relates to use of 1-carbamoylazole derivatives as medicaments and pharmaceutical compositions containing 1-carbamoylazole derivatives as the active ingredient, based on their DPPIV inhibiting effects. The present invention provides a dipeptidyl peptidase IV inhibiting agent com ...