1
Yoshio Kuroda, Eiko Iguchi, Masanobu Kohsaka, Hatsuo Aoki, Hiroshi Imanaka, Yoshihiko Kitaura, Osamu Nakaguchi, Keiji Hemmi, Matsuhiko Aratani, Hidekazu Takeno, Satoshi Okada, Hirokazu Tanaka, Masashi Hashimoto: Peptide, process for preparation thereof and use thereof. Fujisawa Pharmaceutical, Oblon Fisher Spivak McClelland & Maier, January 19, 1982: US04311640 (20 worldwide citation)

The invention deals with novel peptides useful for the therapeutic treatment of infectious diseases caused by pathogenic microorganisms. Included is the peptide FR900156 having the structure: ##STR1## as well as the peptides of the structure ##STR2## wherein R.sup.1 is acyl;


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Yoshihiko Kitaura, Fumitaka Ito, Rodney W Stevens, Nobuko Asai: Antiallergy and antiinflammatory agents, compositions and use. Pfizer, Peter C Richardson, J Trevor Lumb, James M McManus, July 30, 1991: US05036088 (19 worldwide citation)

Compounds of the formula ##STR1## where Y is alkyl, aryl or heterocyclic, n is 1-7, R is hydrogen, alkyl, aralkyl or carboxymethyl, R.sub.1 is acetoxy, thiophenoxy, hydrogen, halo, alkyl, alkoxy or trifluoromethyl, R.sub.2 is hydrogen, alkyl or alkanoyl and X is C.dbd.O, CH.sub.2, NH, O or S as anti ...


3
Yoshihiko Kitaura, Teruo Oku, Hideo Hirai, Tosiyuki Yamamoto, Masashi Hashimoto: Quinolizinone compounds, and pharmaceutical composition comprising the same, useful as anti-ulcerative and anti-allergic agents. Fujisawa Pharmaceutical, Oblon Fisher Spivak McClelland & Maier, October 6, 1987: US04698349 (14 worldwide citation)

The invention relates to novel quinolizinone compounds, of inhibitory activity on allergies and ulcers, of the formula: ##STR1## wherein R.sup.1 is carboxy, carbamoyl Y.sup.1, phenylcarbamoyl which may have hydroxy, cyano or thiocarbamoyl,


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Yoshihiko Kitaura, Fumitaka Ito, Rodney W Stevens, Nobuko Asai: Antiallergy and antiinflammatory agents. Pfizer, Peter C Richardson, J Trevor Lumb, James M McManus, May 30, 1989: US04835166 (9 worldwide citation)

Compounds of the formula ##STR1## where Y is alkyl, aryl or heterocyclic, n is 1-7, R is hydrogen, alkyl, aralkyl or carboxymethyl, R.sub.1 is acetoxy, thiophenoxy, hydrogen, halo, alkyl, alkoxy or trifluoromethyl, R.sub.2 is hydrogen, alkyl or alkanoyl and X is C.dbd.O, CH.sub.2, NH, O or S as anti ...


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Yoshihiko Kitaura, Fumitaka Ito, Rodney W Stevens, Nobuko Asai: Antiallergy and antiinflammatory agents. Pfizer, Peter C Richardson, J Trevor Lumb, James M McManus, February 27, 1990: US04904685 (7 worldwide citation)

Compounds of the formula ##STR1## where Y is alkyl, aryl or heterocyclic, n is 1-7, R is hydrogen, alkyl, aralkyl or carboxymethyl, R.sub.1 is acetoxy, thiophenoxy, hydrogen, halo, alkyl, alkoxy or trifluoromethyl, R.sub.2 is hydrogen, alkyl or alkanoyl and X is C.dbd.O, CH.sub.2, NH, O or S as anti ...


9
Ikuo Ueda, Yoshihiko Kitaura, Nobukiyo Konishi: Phenoxyphenyl acetic acids and their medicinal use. Fujisawa Pharmaceutical, Oblon Fisher Spivak McClelland & Maier, September 18, 1984: US04472433 (7 worldwide citation)

A compound of the formula: ##STR1## wherein R.sup.1 is phenyl substituted with halogen or lower alkyl, and R.sup.4 is a group of the formula C.sub.n H.sub.2n in which n is an integer of 1 to 7; or a pharmaceutically acceptable salt thereof. The compound exhibits antipyretic, analgesic and anti-infla ...


10
Yoshihiko Kitaura, Osamu Nakaguchi, Keiji Hemmi, Matsuhiko Aratani, Hidekazu Takeno, Satoshi Okada, Hirokazu Tanaka, Masashi Hashimoto, Yoshio Kuroda, Eiko Iguchi, Masanobu Kohsaka, Hatsuo Aoki, Hiroshi Imanaka: Cultures of novel strains of Streptomyces. Fujisawa Pharmaceutical, Olbon Fisher Spivak McClelland & Maier, March 12, 1985: US04504584 (7 worldwide citation)

The invention relates to a biologically pure culture of new strains of the microorganism Streptomyces which are capable upon fermentation of producing a peptide of pharmacological activity.