Yonghua Gai (1 - 10 of 79 results)

5 patents

Professor at Northwestern University

Greater Chicago Area | Higher Education

Yonghua Gai, Deqiang Niu, Yat Sun Or, Zhe Wang: Quinoxalinyl tripeptide hepatitis C virus inhibitors. Enanta Pharmaceuticals, Carolyn S Elmore, Edgar W Harlan, Elmore Patent Law Group P C, December 22, 2009: US07635683 (34 worldwide citation)

The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere w ...

Deqiang Niu, Joel D Moore, Dong Liu, Yonghua Gai, Zhigang Chen, Yat Sun Or, Zhe Wang: Acylaminoheteroaryl hepatitis C virus protease inhibitors. Enanta Pharmaceuticals, Carolyn S Elmore, Edgar W Harlan, Elmore Patent Law Group P C, October 20, 2009: US07605126 (24 worldwide citation)

The present invention discloses compounds of formulae I and II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention inte ...

Michael F Parker, Katharin E McElhone, Robert A Mate, Joanne J Bronson, Yonghua Gai, Carl P Bergstrom, Lawrence R Marcin, John E Macor: α-(N-sulfonamido)acetamide derivatives as β-amyloid inhibitors. Bristol Myers Squibb Company, Aldo A Algieri, November 27, 2007: US07300936 (21 worldwide citation)

There is provided a series of novel α-(N-sulfonamido)acetamide compounds of the Formula (I) wherein R, R1, R2 and R3 are defined herein, which are inhibitors of β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by anti-amyloid ac ...

Jacques Banville, Anne Marinier, Yonghua Gai, Serge Plamondon, Stephan Roy, Neelakantan Balasubramanian: Alpha-and beta-substituted trifluoromethyl ketones as phospholipase inhibitors. Bristol Myers Squibb Company, David M Morse, July 2, 2002: US06414179 (20 worldwide citation)

Inhibitors of the cytosolic phospholipase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula

Deqiang Niu, Yonghua Gai, Yat Sun Or, Zhe Wang: Arylalkoxyl hepatitis C virus protease inhibitors. Enanta Pharmaceuticals, Carolyn S Elmore, Edgar W Harlan, Elmore Patent Law Group P C, March 30, 2010: US07687459 (14 worldwide citation)

The present invention discloses compounds of Formula I or II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interf ...

Jacques Banville, Yonghua Gai, Graham Johnson, Fred Christopher Zusi, James R Burke: Trifluoromethyl ketone analogs as selective cPLA2 inhibitors. Bristol Myers Squibb Company, David M Morse, February 26, 2002: US06350892 (10 worldwide citation)

Selective inhibitors of the cPLA

Yat Sun Or, Datong Tang, Yonghua Gai, Ying Sun, Guoyou Xu, Zhe Wang: 3,6-Bicyclolides. Enanta Pharmaceuticals, Elmore Patent Law Group, Darlene A Vanstone, Carolyn S Elmore, June 12, 2007: US07229972 (5 worldwide citation)

The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a sub ...

Michael F Parker, Katharine E McElhone, Robert A Mate, Joanne J Bronson, Yonghua Gai, Carl P Bergstrom, Lawrence R Marcin, John E Macor: α-(N-sulfonamido)acetamide derivatives as β-amyloid inhibitors. Bristol Myers Squibb Company, Aldo A Algieri, Pamela A Mingo, August 31, 2010: US07786122 (5 worldwide citation)

Datong Tang, Guoyou Xu, Yonghua Gai, Zhe Wang, Yat Sun Or, Hui Yin Li: Polymorphic forms of 6-11 bicyclic ketolide derivatives. Enanta Pharmaceuticals, Carolyn S Elmore, Elmore Patent Law Group, June 10, 2008: US07384921 (4 worldwide citation)

The present invention includes EP-13420 polymorphic crystalline forms: Form I, Form II, Form Ia, and monohydrate and amorphous EP-13420 which posses distinct physical properties. In another embodiment of the present invention, there are provided methods of producing the various polymorphic forms in ...

Datong Tang, Yonghua Gai, Ying Sun, Zhigang Chen, Yat Sun Or, Zhe Wang: 11,12-lactone bicyclolides. Enanta Pharmaceuticals, Suanne Nakajima, Carolyn S Elmore, Elmore Patent Law Group, November 6, 2007: US07291602 (4 worldwide citation)

The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subj ...

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