1
Kevin Rodzinak
Donna J Armstrong, Essa H Hu, Michael J Kelly III, Mark E Layton, Yiwei Li, Jun Liang, Kevin J Rodzinak, Michael J Rossi, Philip E Sanderson, Jiabing Wang: Inhibitors of akt activtiy. Merck Sharp & Dohme, Matthew A Leff, David A Mutard, August 30, 2011: US08008317 (4 worldwide citation)

The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt ...


2
Kevin Rodzinak
Jeannie M Arruda, Brian T Campbell, Nicholas D P Cosford, Jacob M Hoffman, Essa H Hu, Mark E Layton, Yiwei Li, Jun Liang, Kevin J Rodzinak, Tony Siu, Brian A Stearns, Lida R Tehrani, Mark T Bilodeau, Peter J Manley: Inhibitors of Akt activity. Merck Sharp & Dohme, Matthew A Leff, David A Muthard, March 22, 2011: US07910561 (1 worldwide citation)

The present invention is directed to compounds which contain substituted naphthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer ...


3
Kevin Rodzinak
Jeannie M Arruda, Brian T Campbell, Nicholas DP Cosford, Jacob M Hoffman, Essa H Hu, Mark E Layton, Yiwei Li, Jun Liang, Kevin J Rodzinak, Tony Siu, Brian A Stearns, Lida R Tehrani, Mark T Bilodeau, Peter J Manley: Inhibitors of Akt Activity. Merck And Co, November 20, 2008: US20080287457-A1

The present invention is directed to compounds which contain substituted naphthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer ...


4
Kevin Rodzinak
Donna J Armstrong, Essa H Hu, Michael J Kelly III, Mark E Layton, Yiwei Li, Jun Liang, Kevin J Rodzinak, Michael A Rossi, Philip E Sanderson, Jiabing Wang: Inhibitors of akt activtiy. Merck, September 2, 2010: US20100222321-A1

The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt ...


5
Larry D Barto, Steven C Nettles, Yiwei Li: Lot start agent that calculates virtual WIP time in a multi-product and multi-bottleneck manufacturing environment. Advanced Micro Devices, Stephen A Terrile, Hamilton & Terrile, May 13, 2003: US06564113 (34 worldwide citation)

A system and method are provided for calculating virtual WIP time (“VWIP”) in a multiple-bottleneck, multi-product manufacturing facility. The system and method provide for calculation of one or more bottleneck VWIP values. Each of the bottleneck VWIP values represents the amount of work approaching ...


6
Larry D Barto, Yiwei Li, Steven C Nettles, H Van Dyke Parunak: Method and apparatus for evaluating bids for scheduling a resource. Advanced Micro Devices, Williams Morgan & Amerson P C, October 5, 2004: US06801819 (26 worldwide citation)

A method for scheduling a resource for processing a workpiece includes defining a commitment window having a kernel specifying a time period required for processing the workpiece. A plurality of candidate bids having candidate commitment windows within the commitment window with varying start times, ...


7
Larry D Barto, Yiwei Li, Steven C Nettles, H Van Dyke Parunak: Method and apparatus for scheduling workpieces with compatible processing requirements. Advanced Micro Devices, Williams Morgan & Amerson P C, August 24, 2004: US06782302 (21 worldwide citation)

A method for processing workpieces using a resource includes generating a plurality of engagements for processing the workpieces by the resource. Each engagement is associated with one of the workpieces and has associated processing requirements. A first one of the plurality of engagements is design ...


8
Larry D Barto, Yiwei Li, Steven C Nettles, H Van Dyke Parunak: Method and apparatus for determining cost functions using parameterized components. Advanced Micro Devices, Williams Morgan & Amerson P C, October 24, 2006: US07127310 (12 worldwide citation)

A method for generating a cost function includes providing a resource for processing a workpiece. A plurality of cost function parameters is provided. A library of parameterized cost function components is acessed based on the plurality of cost function parameters to generate a cost function for pro ...


9
Larry D Barto, Yiwei Li, Steven C Nettles, H Van Dyke Parunak: Method and apparatus for reducing scheduling conflicts for a resource. Advanced Micro Devices, Williams Morgan & Amerson P C, June 27, 2006: US07069097 (12 worldwide citation)

A method includes providing a schedule of engagements for a resource. Each engagement has a working window and an associated engagement density function. The engagement density functions of the scheduled engagements are combined to generate a committed capacity function for the resource. A region of ...


10
Larry D Barto, Yiwei Li, Steven C Nettles, H Van Dyke Parunak: Method and apparatus for scheduling a resource. Advanced Micro Devices, Williams Morgan & Amerson P C, October 12, 2010: US07813993 (11 worldwide citation)

A method includes generating a plurality of bid requests for processing a workpiece. Each bid request is associated with one of a plurality of resources capable of processing the workpiece. For each of the bid requests, a commitment window including a kernel specifying a time period required for pro ...



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