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Andrei W Konradi, Michael A Pleiss, Eugene D Thorsett, Darren B Dressen, Francine S Grant, Christopher Semko, Ying Zi Xu: Heteroaryl, heterocyclic and aryl compounds which inhibit leukocyte adhesion mediated by VLA-4.. Elan Pharmaceuticals, Foley & Lardner, May 23, 2006: US07049306 (33 worldwide citation)

Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, ...


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Andrei W Konradi, Michael A Pleiss, Eugene D Thorsett, Susan Ashwell, Gregory S Welmaker, Anthony Kreft, Dimitrios Sarantakis, Darren B Dressen, Francine S Grant, Christopher Semko, Ying Zi Xu: Heteroaryl, heterocyclic and aryl compounds which inhibit leukocyte adhesion mediated by VLA-4. Elan Pharmaceuticals, American Home Products Corporation, Burns Doane Swecker & Mathis, December 10, 2002: US06492372 (24 worldwide citation)

Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's dis ...


3
Andrei W Konradi, Christopher M Semko, Ying zi Xu, Frank Stappenbeck, Brian P Stupl, Jenifer L Smith, Michael A Pleiss, Eugene D Thorsett: integrins, Heterocyclic compounds which inhibit leukocyte adhesion mediated by α. Elan Pharmaceuticals, Wyeth, Foley & Lardner, April 11, 2006: US07026328 (16 worldwide citation)

Disclosed are compounds which bind α4 integrins, preferably VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by α4 integrins, preferably VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, ...


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Andrei W Konradi, Christopher M Semko, Ying zi Xu, Frank Stappenbeck, Brian P Stupi, Jenifer Smith, Michael A Pleiss, Eugene D Thorsett: integrins, Heterocyclic compounds which inhibit leukocyte adhesion mediated by α. Elan Pharmaceuticals, Foley & Lardner, November 14, 2006: US07135477 (15 worldwide citation)

Disclosed are compounds which bind α4 integrins, preferably VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by α4 integrins, preferably VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, ...


5
Andrei W Konradi, Christopher M Semko, Ying zi Xu, Frank Stappenbeck, Brian P Stupi, Jenifer L Smith, Michael A Pleiss, Eugene D Thorsett: integrins, Heterocyclic compounds which inhibit leukocyte adhesion mediated by α. Elan Pharmaceuticals, Wyeth, Foley & Lardner, March 7, 2006: US07008949 (15 worldwide citation)

Disclosed are compounds which bind α4 integrins, where the α4 integrin is preferably VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by α4 integrins, where the α4 integrin is preferably VLA-4. Such compounds are useful in the treatmen ...


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Andrei W Konradi, Michael A Pleiss, Eugene D Thorsett, Darren B Dressen, Francine S Grant, Christopher Semko, Ying Zi Xu: Heteroaryl, heterocyclic and aryl compounds which inhibit leukocyte adhesion mediated by VLA-4. Elan Pharmaceuticals, Foley & Lardner, February 28, 2006: US07005433 (14 worldwide citation)

Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, ...


8
Andrei W Konradi, Michael A Pleiss, Eugene D Thorsett, Susan Ashwell, Gregory S Welmaker, Anthony Kreft, Dimitrios Sarntakis, Darren B Dressen, Francine S Grant, Christopher Semko, Ying Zi Xu: Heteroaryl, heterocyclic and aryl compounds which inhibit leukocyte adhesion mediated by VLA-4. Elan Pharmaceuticals, Wyeth, Foley & Lardner, June 28, 2005: US06911439 (14 worldwide citation)

Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, ...


9
Andrei W Konradi, Michael A Pleiss, Eugene D Thorsett, Susan Ashwell, Gregory S Welmaker, Anthony Kreft, Dimitrios Sarantakis, Darren B Dressen, Francine S Grant, Christopher Semko, Ying Zi Xu: Heteroaryl, heterocyclic and aryl compounds which inhibit leukocyte adhesion mediated by VLA-4. Wyeth, Foley & Lardner, May 27, 2008: US07378529 (13 worldwide citation)

Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, ...


10
Andrei W Konradi, Christopher M Semko, Ying zi Xu, Frank Stappenbeck, Brian P Stupi, Jenifer Smith, Michael A Pleiss, Eugene D Thorsett: integrins, Heterocyclic compounds which inhibit leukocyte adhesion mediated by α. Elan Pharmaceuticals, Foley & Lardner, September 23, 2008: US07427628 (13 worldwide citation)

Disclosed are compounds which bind α4 integrins, preferably VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by α4 integrins, preferably VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, ...