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Ying Weiwen, James David, Zhang Shijie, Przewloka Teresa, Chae Junghyun, Chimmanamada Dinesh U, Lee Chi Wan, Kostik Elena, Ng Howard P, Foley Kevin, Du Zhenjian, Barsoum James: Triazole compounds that modulate hsp90 activity. Synta Pharmaceuticals, Ying Weiwen, James David, Zhang Shijie, Przewloka Teresa, Chae Junghyun, Chimmanamada Dinesh U, Lee Chi Wan, Kostik Elena, Ng Howard P, Foley Kevin, Du Zhenjian, Barsoum James, DAVID Steven G, May 26, 2006: WO/2006/055760 (49 worldwide citation)

The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, s ...


2
Sun Lijun, Borella Christopher, Li Hao, Jiang Jun, Chen Shoujun, Koya Keizo, Inoue Takayo, Du Zhenjian, Foley Kevin, Wu Yaming, Zhang Mei, Ying Weiwen: Isoxazole combretastin derivatives for the treatment of disorders. Synta Pharmaceuticals, Sun Lijun, Borella Christopher, Li Hao, Jiang Jun, Chen Shoujun, Koya Keizo, Inoue Takayo, Du Zhenjian, Foley Kevin, Wu Yaming, Zhang Mei, Ying Weiwen, DAVIS Steven G, August 24, 2006: WO/2006/089177 (40 worldwide citation)

The invention relates to compounds of structural formula (I); or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative ...


3
Sun Lijun, Ono Mitsunori, Wada Yumiko, Ying Weiwen, Przewloka Teresa, Kostik Elena: Aromatic bicyclic heterocyles to modulate 1l - 12 production. Synta Pharmaceuticals, Sun Lijun, Ono Mitsunori, Wada Yumiko, Ying Weiwen, Przewloka Teresa, Kostik Elena, HSI Jeffrey D, April 29, 2004: WO/2004/035740 (18 worldwide citation)

This invention features a compound of formula (I): R1 is aryl or heteroaryl; each of R2 and R4, independently, is H, halogen, CN, alkyl, ORa, or NRaRb; R3 is H, halogen, CN, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cyclyl, heterocyclyl, ORa, OC(O)Ra, OC(O)NRaRb, NRaRb, NRaC(O)Rb, NRaS(O)Rb, NRaS(O ...


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Chae Junghyun, Demko Zachary, Ying Weiwen, Du Zhenjian, Foley Kevin, James David, Przewloka Teresa, Song Minghu, Zhang Shijie, Ng Howard P, Li Hao, Chimmanamada Dinesh U, Sun Lijun, Koya Keizo, Zhou Dan, Qin Shuzhen, Lee Chi Wan: Triazole compounds that modulate hsp90 activity. Synta Pharmaceuticals, Chae Junghyun, Demko Zachary, Ying Weiwen, Du Zhenjian, Foley Kevin, James David, Przewloka Teresa, Song Minghu, Zhang Shijie, Ng Howard P, Li Hao, Chimmanamada Dinesh U, Sun Lijun, Koya Keizo, Zhou Dan, Qin Shuzhen, Lee Chi Wan, DAVIS Steven G, December 6, 2007: WO/2007/139955 (14 worldwide citation)

The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, s ...


5
Zhou Dan, Qin Shuzen, Ying Weiwen: Method for treating inflammatory disorders. Synta Pharmaceuticals, Zhou Dan, Qin Shuzen, Ying Weiwen, DAVIS Steven G, May 15, 2008: WO/2008/057246 (13 worldwide citation)

The present invention relates to a method for suppressing the immune system in a subject in need thereof, and a method for treating an inflammatory or immune disorder in a subject in need thereof.


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Lee Chi Wan, Przewloka Teresa, Ying Weiwen, Song Minghu, Du Zhenjian, Foley Kevin, Zhou Dan, Qin Shuzhen: Triazinone and diazinone derivatives useful as hsp90 inhibitors. Synta Pharmaceuticals, Lee Chi Wan, Przewloka Teresa, Ying Weiwen, Song Minghu, Du Zhenjian, Foley Kevin, Zhou Dan, Qin Shuzhen, DAVIS Steven G, October 2, 2008: WO/2008/118391 (13 worldwide citation)

The present invention relates to compounds according to formulae (IA) to (ID) and compositions that inhibit the activity of Hsp90. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disor ...


7
Chimmanamada Dinesh U, Burlison Joseph A, Ying Weiwen, Sun Lijun, Schweizer Stefan Michael, Zhang Shijie, Demko Zachary, James David, Przewloka Teresa: Triazole compounds that are useful in the treatment of proliferative disorders, such as cancer. Synta Pharmaceuticals, Chimmanamada Dinesh U, Burlison Joseph A, Ying Weiwen, Sun Lijun, Schweizer Stefan Michael, Zhang Shijie, Demko Zachary, James David, Przewloka Teresa, DAVIS Steven G, August 14, 2008: WO/2008/097640 (11 worldwide citation)

The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to the use of a substituted triazole compound of the invention, or a composition comprising such a compound in the preparation of a medicament for ...


8
Ying Weiwen, Sun Lijun, Koya Keizo, Chimmanamada Dinesh U, Zhang Shijie, Przewloka Teresa, Li Hao: Triazole compounds that modulate hsp90 activity. Synta Pharmaceuticals, Ying Weiwen, Sun Lijun, Koya Keizo, Chimmanamada Dinesh U, Zhang Shijie, Przewloka Teresa, Li Hao, DAVIS Steven G, February 19, 2009: WO/2009/023211 (11 worldwide citation)

The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, s ...


9
Foley Kevin, Ying Weiwen: Triazole compounds that modulate hsp90 activity. Synta Pharmaceuticals, Foley Kevin, Ying Weiwen, DAVIS Steven G, February 21, 2008: WO/2008/021364 (11 worldwide citation)

The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of treating or inhibiting angiogenesis in a subject in need thereof and methods for blocking, occluding, or otherwise disrupting blood ...


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Koya Keizo, Ying Weiwen, Przewloka Teresa, Sun Lijun: Compounds for treating proliferative disorders. Synta Pharmaceuticals, Koya Keizo, Ying Weiwen, Przewloka Teresa, Sun Lijun, DAVIS Steven G, November 13, 2008: WO/2008/136976 (10 worldwide citation)

Disclosed are compounds and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also, disclosed are pharmaceutical compositions comprising c ...