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Yasuhiko Hirayama, Haruko Ikata, Satoshi Ojima, Hiromi Matsuzaki: Artificial intervertebral disc. Asahi Kogaku Kogyo Kabushiki Kaisha, Sandler Greenblum & Bernstein, August 7, 1990: US04946378 (423 worldwide citation)

An artificial intervertebral disc comprises a pair of end bodies which are provided, on their outer surfaces, with apatite layers. The disc includes a medical synthetic polymeric intermediate which is held between the end bodies through connecting members.


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Masahide Inoue, Takeshi Ichitsuka, Yasuhiko Hirayama, Shozo Koshikawa, Tateki Kitaoka, Nobuo Nakabayashi, Tatsumichi Takeda, Osamu Minoo: Support for biomedical implant device. Asahi Kogaku Kogyo Kabushiki Kaisha, Sughrue Mion Zinn Macpeak and Seas, January 17, 1989: US04798585 (64 worldwide citation)

A support for a biomedical implant device in which the support has a surface layer composed of a biocompatible calcium phosphate material such as sintered hydroxyapatite with a porosity of 50-60% and pore size of 0.5-500 micrometers. Preferably, the surface layer is formed with projections or recess ...


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Yasuhiko Hirayama, Haruko Ikata, Satoshi Ojima: Apatite coated article and process for producing the same. Asahi Kogaku Kogyo, Sughrue Mion Zinn Macpeak & Seas, July 7, 1992: US05128146 (23 worldwide citation)

An apatite coated article comprising a substrate having thereon an apatite layer which is formed by flame spraying apatite powder at from about 2,000.degree. to 4,000.degree. C., and a process for producing such an apatite coated article.


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Masahide Inoue, Takeshi Ichitsuka, Yasuhiko Hirayama, Shozo Koshikawa, Tateki Kitaoka, Nobuo Nakabayashi, Tatsumichi Takeda, Osamu Minoo: Support for biomedical implant device. Asahi Kogaku Kogyo, Sughrue Mion Zinn Macpeak & Seas, August 18, 1992: USRE034037

A support for a biomedical implant device in which the support has a surface layer composed of a biocompatible calcium phosphate material such as sintered hydroxyapatite with a porosity of 50-60% and pore size of 0.5-500 micrometers. Preferably, the surface layer is formed with projections or recess ...